About   Help   FAQ
Sirt2
Gene Detail
Symbol

Name
ID
Sirt2
sirtuin 2
MGI:1927664
Synonyms
5730427M03Rik, Sir2l, SIR2L2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
16.92 cM, cytoband B1-2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:28766735-28788660 bp, + strand
From VEGA annotation of GRCm38

  21926 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40823  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: NAD-dependent deacetylase sirtuin-2, eukaryotic type
Gene Tree: Sirt2

Human
homologs
Human Homolog SIRT2, sirtuin 2
NCBI Gene ID 22933
neXtProt AC  NX_Q8IXJ6
Human Synonyms  SIR2, SIR2L, SIR2L2
Human Chr (Location)  19q13; chr19:38878555-38899862 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(6) Targeted(6)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for a floxed allele activated in Schwann cells exhibit delayed myelination during development and following a nerve crush injury. Mice homozygous for a knock-out allele exhibit increased tumor formation and abnormal mitosis.
 
Phenotype Images(3)
Interactions
Sirt2 interacts with 94 markers (Mir19b-1, Mir19b-2, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (147 annotations)
Process autophagy, cell cycle, ...
Component cell projection, centriole, ...
Function (3,5-dichlorophenylurea)acetate amidohydrolase activity, 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (13)    Tissues (9)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
RT-PCR 10
cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(7) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017294 (Evidence)
Ensembl Gene ModelENSMUSG00000015149 (Evidence)
Entrez Gene64383 (Evidence)
DFCITC1688015, TC1587002, TC1572731
DoTSDT.97367253, DT.97378665, DT.97378668, DT.97378670
NIA Mouse Gene IndexU112075
EC3.5.1.-
Consensus CDS ProjectCCDS21055.1, CCDS52165.1
International Mouse Knockout Project StatusSirt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017294 VEGA Gene Model | MGI Sequence Detail 21926 C57BL/6J ±  kb
transcript OTTMUST00000041937 VEGA | MGI Sequence Detail 1843 Not Applicable 
polypeptide OTTMUSP00000018858 VEGA | MGI Sequence Detail 389 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017328 NAD-dependent deacetylase sirtuin-2, sirtuin family, class I
InterPro IPR003000 Sirtuin family
InterPro IPR026590 Sirtuin family, catalytic core domain
Protein Ontology PR:000014889 NAD-dependent protein deacetylase sirtuin-2
References
(Earliest) J:65632 Yang YH, et al., Cloning and characterization of two mouse genes with homology to the yeast sir2 gene. Genomics. 2000 Nov 1;69(3):355-69
(Latest) J:211669 Wang YP, et al., Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. EMBO J. 2014 Jun 17;33(12):1304-20
All references(66)
Other
accession IDs
MGI:1915014

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory