Ms4a8a MGI Mouse Gene Detail - MGI:1927657 - membrane-spanning 4-domains, subfamily A, member 8A

Symbol

Ms4a8a
Name

membrane-spanning 4-domains, subfamily A, member 8A
Synonyms

2010004L09Rik, CD20L5, Ms4a8

Feature Type

protein coding gene
IDs

MGI:1927657
NCBI Gene: 64381
Member of

Ms4ac cluster
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr19:11044835-11058466 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 7.62 cM
Mapping Data

2 experiments

SNPs within 2kb

390 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927657	protein coding gene	Chr19:11044835-11058467 (-)
129S1/SvImJ	ENSMUSG00200048958	protein coding gene	Chr19:7723909-7737564 (-)
A/J	ENSMUSG00195052699	protein coding gene	Chr19:7936895-7950539 (-)
AKR/J	ENSMUSG00220044559	protein coding gene	Chr19:7844796-7858444 (-)
BALB/cJ	ENSMUSG00180036539	protein coding gene	Chr19:8298640-8312297 (-)
C3H/HeJ	ENSMUSG00175010659	protein coding gene	Chr19:7569669-7583283 (-)
C57BL/6NJ	ENSMUSG00215040009	protein coding gene	Chr19:7641220-7654863 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022711	protein coding gene	Chr19:8319950-8335486 (-)
CAST/EiJ	ENSTCUG00005027162	protein coding gene	Chr19:7452797-7466049 (-)
CBA/J	ENSMUSG00210043540	protein coding gene	Chr19:7768233-7781843 (-)
DBA/2J	ENSMUSG00185051050	protein coding gene	Chr19:8177961-8191585 (-)
FVB/NJ	ENSMUSG00205024645	protein coding gene	Chr19:7659285-7672930 (-)
JF1/MsJ	ENSUMUG00000055059	protein coding gene	Chr19:8304251-8318021 (-)
LP/J	ENSMUSG00230052085	protein coding gene	Chr19:9098535-9112178 (-)
NOD/ShiLtJ	ENSMUSG00190035608	protein coding gene	Chr19:7396462-7410114 (-)
NZO/HlLtJ	ENSMUSG00225043885	protein coding gene	Chr19:12807378-12821041 (-)
PWK/PhJ	ENSLUMG00010007460	protein coding gene	Chr19:7702110-7715836 (-)
SPRET/EiJ	ENSMSPG00010037624	protein coding gene	Chr19:7537006-7550642 (-)
WSB/EiJ	ENSIUOG00005049708	protein coding gene	Chr19:7298669-7312381 (-)

Human Ortholog

MS4A8, membrane spanning 4-domains A8

Vertebrate Orthologs

14

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MS4A8, membrane spanning 4-domains A8
Synonyms

4SPAN4, CD20L5, MS4A4, MS4A8B
Links

HGNC:13380

NCBI Gene ID: 83661

UniProt: Q9BY19
Chr Location

11q12.2; chr11:60699585-60715811 (+) GRCh38

MGI Vertebrate Homology

Ms4a8a stringent orthology
1 human;1 mouse;1 rat;12 zebrafish
HCOP

vertebrate homology predictions: MS4A8
Gene Tree

Ms4a8a

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

3
Genomic Mutations

1 involving Ms4a8a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

602
Tissues

2
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

2
UniProt

1
CCDS

CCDS37921.1

Ensembl

ENSMUSG00000024730 (Evidence)
NCBI Gene

64381

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024730	Ensembl Gene Model \| MGI Sequence Detail	13632	C57BL/6J	± kb
transcript	ENSMUST00000025636	Ensembl \| MGI Sequence Detail	1081	Not Applicable
polypeptide	ENSMUSP00000025636	Ensembl \| MGI Sequence Detail	290	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010663 membrane-spanning 4-domains subfamily A member 8B

(term hierarchy)
InterPro Domains

IPR007237 CD20-like, transmembrane domain

IPR030417 Membrane-spanning 4-domains subfamily A

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All nucleic 13

cDNA 13

Microarray probesets 3

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MGI:1917053, MGI:2147566

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:360865 Jiang HC, et al., CD20/MS4A1 is a mammalian olfactory receptor expressed in a subset of olfactory sensory neurons that mediates innate avoidance of predators. Nat Commun. 2024 Apr 18;15(1):3360

TSS for Ms4a8a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158290	Chr19:11058452-11058475 (-)	2 bp
Tssr158289	Chr19:11058430-11058441 (-)	30 bp
Tssr158288	Chr19:11058398-11058409 (-)	62 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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