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Gpr88 Gene Detail
Summary
  • Symbol
    Gpr88
  • Name
    G-protein coupled receptor 88
  • Synonyms
    Strg
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927653
    NCBI Gene: 64378
  • Gene Overview
    MyGene.info: GPR88
Location & Maps
more
  • Sequence Map
    Chr3:116249654-116253503 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3850 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 50.23 cM, cytoband G1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GPR88, G protein-coupled receptor 88
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GPR88, G protein-coupled receptor 88
    Orthology source: HomoloGene
  • Synonyms
    COCPMR, STRG
  • Links
    NCBI Gene ID: 54112
    neXtProt AC: NX_Q9GZN0

  • Chr Location
    1p21.3; chr1:100538172-100542027 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GPR88 associations

Human Disease Mouse Models
       Chorea, Childhood-Onset, with Psychomotor Retardation; COCPMR   OMIM: 616939
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Gpr88
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054451 VEGA Gene Model | MGI Sequence Detail 3850 C57BL/6J ±  kb
transcript OTTMUST00000135035 VEGA | MGI Sequence Detail 3469 Not Applicable  
polypeptide OTTMUSP00000071536 VEGA | MGI Sequence Detail 384 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    18 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001541 G-protein coupled receptor 88
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:2139966
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:65631 Mizushima K, et al., A novel G-protein-coupled receptor gene expressed in striatum. Genomics. 2000 Nov 1;69(3):314-21
  • Latest
    J:226277 Zhang K, et al., Loss of glutamic acid decarboxylase (Gad67) in striatal neurons expressing the Drdr1a dopamine receptor prevents L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned mice. Neuroscience. 2015 Sep 10;303:586-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory