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Rsph6a Gene Detail
Summary
  • Symbol
    Rsph6a
  • Name
    radial spoke head 6 homolog A (Chlamydomonas)
  • Synonyms
    Rshl1, RSP4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927643
    NCBI Gene: 83434
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:18788615-18808372 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.46 cM, cytoband A2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    133 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927643
protein coding gene Chr7:18788603-18808384 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031755
protein coding gene Chr7:17001661-17025321 (+)
A/J MGP_AJ_G0031731
protein coding gene Chr7:16695243-16714707 (+)
AKR/J MGP_AKRJ_G0031657
protein coding gene Chr7:17153150-17173690 (+)
BALB/cJ MGP_BALBcJ_G0031736
protein coding gene Chr7:16888031-16907416 (+)
C3H/HeJ MGP_C3HHeJ_G0031458
protein coding gene Chr7:17406033-17432689 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032202
protein coding gene Chr7:17893066-17917913 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029268
protein coding gene Chr7:18340155-18362974 (+)
CAST/EiJ MGP_CASTEiJ_G0030801
protein coding gene Chr7:13811566-13833591 (+)
CBA/J MGP_CBAJ_G0031420
protein coding gene Chr7:18537227-18561207 (+)
DBA/2J MGP_DBA2J_G0031575
protein coding gene Chr7:16630349-16650067 (+)
FVB/NJ MGP_FVBNJ_G0031527
protein coding gene Chr7:16492108-16513882 (+)
LP/J MGP_LPJ_G0031658
protein coding gene Chr7:17345291-17370697 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031563
protein coding gene Chr7:18402745-18429549 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032230
protein coding gene Chr7:16754652-16779162 (+)
PWK/PhJ MGP_PWKPhJ_G0030525
protein coding gene Chr7:13713717-13738423 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030352
protein coding gene Chr7:11439503-11463806 (+)
WSB/EiJ MGP_WSBEiJ_G0030901
protein coding gene Chr7:16959599-16979968 (+)



Homology
more
  • Human Ortholog
    RSPH6A, radial spoke head 6 homolog A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RSPH6A, radial spoke head 6 homolog A
  • Synonyms
    RSHL1, RSP4, RSP6, RSPH4B
  • Links
    NCBI Gene ID: 81492
    neXtProt AC: NX_Q9H0K4
    UniProt: Q9H0K4

  • Chr Location
    19q13.32; chr19:45795713-45815308 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null mutation display infertility with immotile sperm, and abnormal sperm heads and tails.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040866 Ensembl Gene Model | MGI Sequence Detail 19758 C57BL/6J ±  kb
    transcript ENSMUST00000035521 Ensembl | MGI Sequence Detail 2354 Not Applicable  
    polypeptide ENSMUSP00000046526 Ensembl | MGI Sequence Detail 708 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 2
    References
    more
    • Summaries
      All 23
      Gene Ontology 8
      Phenotypes 2
    • Earliest
      J:67997 Eriksson M, et al., A Mammalian Radial Spokehead-Like Gene, RSHL1, at the Myotonic Dystrophy-1 Locus. Biochem Biophys Res Commun. 2001 Mar 9;281(4):835-41
    • Latest
      J:332237 Zhang X, et al., Differential requirements of IQUB for the assembly of radial spoke 1 and the motility of mouse cilia and flagella. Cell Rep. 2022 Nov 22;41(8):111683

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory