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Trps1
Gene Detail
Symbol

Name
ID
Trps1
trichorhinophalangeal syndrome I (human)
MGI:1927616
Synonyms
D15Ertd586e
Feature Type
protein coding gene
Genetic Map
Chromosome 15
19.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr15:50654752-50890463 bp, - strand
From VEGA annotation of GRCm38

  235712 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8556  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TRPS1
Gene Tree: Trps1

Human
homologs
TRPS1, trichorhinophalangeal syndrome I
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7227
neXtProt AC: NX_Q9UHF7

Human Synonyms: GC79, LGCR

Human Chr (Location): 8q24.12; chr8:115408496-115669580 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TRPS1

Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Chemically induced (ENU)(1) Gene trapped(17) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Newborn mice homozygous for a knock-out allele exhibit craniofacial and hair anomalies and die of respiratory failure due to thoracic spine and rib defects. Mice homozygous for a reporter allele show additional defects in chondrocyte proliferation and apoptosis as well as reduced nephron formation.
 
Human Diseases Modeled in Mice Using Trps1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Trps1 interacts with 526 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process chondrocyte differentiation, negative regulation of transcription, DNA-templated, ...
Component nucleoplasm, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (690)    Tissues (257)    Images (92)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 653
Northern blot 9
RT-PCR 16
cDNA source data(120)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase trps1    NEW 
Molecular
reagents
All nucleic(126) cDNA(122) Primer pair(4)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000044609 (Evidence)
Ensembl Gene Model ENSMUSG00000038679 (Evidence)
Entrez Gene 83925 (Evidence)
UniGene 30466
DFCI TC1677915, TC1631107, TC1582722, TC1615859, TC1589305, TC1606953, TC1596416
DoTS DT.40166534, DT.527605, DT.101354448, DT.101367575, DT.486897, DT.101134150, DT.99850349
NIA Mouse Gene Index U083059, U093481
Consensus CDS Project CCDS27460.1
International Mouse Phenotyping Consortium Status Trps1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044609 VEGA Gene Model | MGI Sequence Detail 235712 C57BL/6J ±  kb
transcript OTTMUST00000117348 VEGA | MGI Sequence Detail 6202 Not Applicable 
polypeptide OTTMUSP00000065622 VEGA | MGI Sequence Detail 1285 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(20) UniProt(13)
Polymorphisms
RFLP(1) : SNPs within 2kb(2040 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR000679 Zinc finger, GATA-type
InterPro IPR013088 Zinc finger, NHR/GATA-type
Protein Ontology PR:000016704 zinc finger transcription factor Trps1
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:220362 Sun Y, et al., Trps1 deficiency inhibits the morphogenesis of secondary hair follicles via decreased Noggin expression. Biochem Biophys Res Commun. 2015 Jan 16;456(3):721-6
All references(68)
Disease annotation references (1)
Other
accession IDs
MGI:1261920, MGI:2145946, MGI:2146008

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory