About   Help   FAQ
Trps1
Gene Detail
 Symbol
Name
ID
Trps1
trichorhinophalangeal syndrome I (human)
MGI:1927616
Synonyms D15Ertd586e
Feature Type protein coding gene
Genetic Map
Chromosome 15
19.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr15:50654752-50890463 bp, - strand
From VEGA annotation of GRCm38

  235712 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8556  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Trps1

Human
homologs
Human Homolog TRPS1, trichorhinophalangeal syndrome I
NCBI Gene ID 7227
neXtProt AC  NX_Q9UHF7
Human Synonyms  GC79, LGCR
Human Chr (Location)  8q24.12; chr8:115408496-115669028 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human TRPS1
Alleles
and
phenotypes
All alleles(21) : Chemically induced (ENU)(1) Gene trapped(17) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Newborn mice homozygous for a knock-out allele exhibit craniofacial and hair anomalies and die of respiratory failure due to thoracic spine and rib defects. Mice homozygous for a reporter allele show additional defects in chondrocyte proliferation and apoptosis as well as reduced nephron formation.
 
Human Diseases Modeled Using Mouse Trps1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process chondrocyte differentiation, negative regulation of transcription, DNA-templated, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (697)    Tissues (262)    Images (92)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 653
Northern blot 9
RT-PCR 23
cDNA source data(120)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(126) cDNA(122) Primer pair(4)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000044609 (Evidence)
Ensembl Gene ModelENSMUSG00000038679 (Evidence)
Entrez Gene83925 (Evidence)
UniGene30466
DFCITC1582722, TC1589305, TC1596416, TC1606953, TC1615859, TC1631107, TC1677915
DoTSDT.101134150, DT.101354448, DT.101367575, DT.40166534, DT.486897, DT.527605, DT.99850349
NIA Mouse Gene IndexU083059, U093481
Consensus CDS ProjectCCDS27460.1
International Mouse Knockout Project StatusTrps1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044609 VEGA Gene Model | MGI Sequence Detail 235712 C57BL/6J ±  kb
transcript OTTMUST00000117348 VEGA | MGI Sequence Detail 6202 Not Applicable 
polypeptide OTTMUSP00000065622 VEGA | MGI Sequence Detail 1285 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(10) UniProt(13)
Polymorphisms RFLP(1) : SNPs within 2kb(2040 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR000679 Zinc finger, GATA-type
InterPro IPR013088 Zinc finger, NHR/GATA-type
Protein Ontology PR:000016704 zinc finger transcription factor Trps1
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:199884 Wojciechowicz K, et al., Development of the mouse dermal adipose layer occurs independently of subcutaneous adipose tissue and is marked by restricted early expression of FABP4. PLoS One. 2013;8(3):e59811
All references(66)
Other
accession IDs
MGI:1261920, MGI:2145946, MGI:2146008

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory