Tas1r1
Gene Detail

Symbol Name ID

Tas1r1 taste receptor, type 1, member 1 MGI:1927505

Synonyms

Gpr70, T1r1, T1R1, TR1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

82.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr4:152027914-152038568 bp, - strand From VEGA annotation of GRCm38   10655 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12888  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Tas1r1

Human homologs

Human Homolog		TAS1R1, taste receptor, type 1, member 1
NCBI Gene ID		80835
neXtProt AC		NX_Q7RTX1
Human Synonyms		GPR70, T1R1, TR1
Human Chr (Location)		1p36.23; chr1:6615338-6639817 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Homozygous mutant mice show diminished behavioral and nervous responses to umami tastants. Response to sweet tastants is unimpaired.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	detection of chemical stimulus involved in sensory perception of taste, G-protein coupled receptor signaling pathway, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, signal transducer activity, ...

External Resources: FuncBase

Expression

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) Genomic(1) cDNA(10) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000010375 (Evidence)
Ensembl Gene Model	ENSMUSG00000028950 (Evidence)
Entrez Gene	110326 (Evidence)
UniGene	29232
DFCI	TC1588204, TC1657055
DoTS	DT.40150493, DT.91384717, DT.94169748
NIA Mouse Gene Index	U025837
Consensus CDS Project	CCDS18985.1
International Mouse Knockout Project Status	Tas1r1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010375	VEGA Gene Model | MGI Sequence Detail	10655	C57BL/6J
transcript	OTTMUST00000024187	VEGA | MGI Sequence Detail	2863	Not Applicable
polypeptide	OTTMUSP00000011121	VEGA | MGI Sequence Detail	842	Not Applicable

All sequences(27) RefSeq(2) UniProt(2)

Polymorphisms

PCR(1) : SNPs(47 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR000337	GPCR, family 3
InterPro	IPR017979	GPCR, family 3, conserved site
InterPro	IPR017978	GPCR, family 3, C-terminal
InterPro	IPR011500	GPCR, family 3, nine cysteines domain
Protein Ontology	PR:000016060	taste receptor type 1 member 1

References

(Earliest) J:53048 Hoon MA, et al., Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell. 1999 Feb 19;96(4):541-51
(Latest) J:188117 Wauson EM, et al., The G Protein-Coupled Taste Receptor T1R1/T1R3 Regulates mTORC1 and Autophagy. Mol Cell. 2012 Sep 28;47(6):851-62
All references(41)

Other accession IDs

MGI:1340021