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Tas1r1
Gene Detail
Symbol

Name
ID
Tas1r1
taste receptor, type 1, member 1
MGI:1927505
Synonyms
Gpr70, T1r1, T1R1, TR1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
82.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr4:152027914-152038568 bp, - strand
From VEGA annotation of GRCm38

  10655 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12888  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

HCOP human homology predictions: TAS1R1
Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Tas1r1

Human
homologs
TAS1R1, taste receptor, type 1, member 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 80835
neXtProt AC: NX_Q7RTX1

Human Synonyms: GM148, GPR70, T1R1, TR1

Human Chr (Location): 1p36.23; chr1:6555278-6579757 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Targeted(9)
Genomic Mutations involving Tas1r1 (3)
 
Homozygous mutant mice show diminished behavioral and nervous responses to umami tastants. Response to sweet tastants is unimpaired.
 
Interactions
Tas1r1 interacts with 57 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (1 records)
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100495087 ; ZFIN tas1r1    NEW 
Molecular
reagents
All nucleic(12) Genomic(1) cDNA(10) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000010375 (Evidence)
Ensembl Gene Model ENSMUSG00000028950 (Evidence)
Entrez Gene 110326 (Evidence)
UniGene 29232
DFCI TC1657055, TC1588204
DoTS DT.94169748, DT.40150493, DT.91384717
NIA Mouse Gene Index U025837
Consensus CDS Project CCDS18985.1
International Mouse Phenotyping Consortium Status Tas1r1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010375 VEGA Gene Model | MGI Sequence Detail 10655 C57BL/6J ±  kb
transcript OTTMUST00000024187 VEGA | MGI Sequence Detail 2863 Not Applicable 
polypeptide OTTMUSP00000011121 VEGA | MGI Sequence Detail 842 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR011500 GPCR, family 3, nine cysteines domain
Protein Ontology PR:000016060 taste receptor type 1 member 1
References
(Earliest) J:53048 Hoon MA, et al., Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell. 1999 Feb 19;96(4):541-51
(Latest) J:217303 Koudelka J, et al., Genetic dissection of TrkB activated signalling pathways required for specific aspects of the taste system. Neural Dev. 2014;9:21
All references(47)
Other
accession IDs
MGI:1340021

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory