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Tas1r1
Gene Detail
Symbol

Name
ID
Tas1r1
taste receptor, type 1, member 1
MGI:1927505
Synonyms
Gpr70, T1r1, T1R1, TR1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
82.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr4:152027914-152038568 bp, - strand
From VEGA annotation of GRCm38

  10655 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12888  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Tas1r1

Human
homologs
Human Homolog TAS1R1, taste receptor, type 1, member 1
NCBI Gene ID 80835
neXtProt AC  NX_Q7RTX1
Human Synonyms  GPR70, T1R1, TR1
Human Chr (Location)  1p36.23; chr1:6555278-6579757 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Genomic Mutations involving Tas1r1 (2)
 
Homozygous mutant mice show diminished behavioral and nervous responses to umami tastants. Response to sweet tastants is unimpaired.
 
Interactions
Tas1r1 interacts with 57 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) Genomic(1) cDNA(10) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000010375 (Evidence)
Ensembl Gene ModelENSMUSG00000028950 (Evidence)
Entrez Gene110326 (Evidence)
UniGene29232
DFCITC1588204, TC1657055
DoTSDT.94169748, DT.91384717, DT.40150493
NIA Mouse Gene IndexU025837
Consensus CDS ProjectCCDS18985.1
International Mouse Knockout Project StatusTas1r1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010375 VEGA Gene Model | MGI Sequence Detail 10655 C57BL/6J ±  kb
transcript OTTMUST00000024187 VEGA | MGI Sequence Detail 2863 Not Applicable 
polypeptide OTTMUSP00000011121 VEGA | MGI Sequence Detail 842 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR011500 GPCR, family 3, nine cysteines domain
Protein Ontology PR:000016060 taste receptor type 1 member 1
References
(Earliest) J:53048 Hoon MA, et al., Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell. 1999 Feb 19;96(4):541-51
(Latest) J:207353 Kusuhara Y, et al., Taste responses in mice lacking taste receptor subunit T1R1. J Physiol. 2013 Apr 1;591(Pt 7):1967-85
All references(47)
Other
accession IDs
MGI:1340021

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory