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Tas1r1 Gene Detail
Summary
  • Symbol
    Tas1r1
  • Name
    taste receptor, type 1, member 1
  • Synonyms
    Gpr70, T1r1, T1R1, TR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927505
    NCBI Gene: 110326
  • Gene Overview
    MyGene.info: TAS1R1
Location & Maps
more
  • Sequence Map
    Chr4:152027914-152038568 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10655 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 82.83 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    TAS1R1, taste 1 receptor member 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TAS1R1, taste 1 receptor member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GM148, GPR70, T1R1, TR1
  • Links
    NCBI Gene ID: 80835
    neXtProt AC: NX_Q7RTX1

  • Chr Location
    1p36.31; chr1:6555278-6579757 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    1
  • Targeted
    9
  • Genomic Mutations
    3 involving Tas1r1
Homozygous mutant mice show diminished behavioral and nervous responses to umami tastants. Response to sweet tastants is unimpaired.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010375 VEGA Gene Model | MGI Sequence Detail 10655 C57BL/6J ±  kb
transcript OTTMUST00000024187 VEGA | MGI Sequence Detail 2863 Not Applicable  
polypeptide OTTMUSP00000011121 VEGA | MGI Sequence Detail 842 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    52 from dbSNP Build 142
  • PCR
Protein
Information
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Molecular
Reagents
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  • All nucleic 12
    Genomic 1
    cDNA 10
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1340021
References
more
  • Summaries
    All 45
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:53048 Hoon MA, et al., Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell. 1999 Feb 19;96(4):541-51
  • Latest
    J:227815 Kendig DM, et al., Activation of the umami taste receptor (T1R1/T1R3) initiates the peristaltic reflex and pellet propulsion in the distal colon. Am J Physiol Gastrointest Liver Physiol. 2014 Dec 1;307(11):G1100-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory