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Tas1r1 Gene Detail
Summary
  • Symbol
    Tas1r1
  • Name
    taste receptor, type 1, member 1
  • Synonyms
    Gpr70, T1r1, T1R1, TR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927505
    NCBI Gene: 110326
  • Gene Overview
    MyGene.info: TAS1R1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:152027914-152038490 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 82.83 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927505
protein coding gene Chr4:152027914-152038568 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029169
protein coding gene Chr4:156126314-156137524 (-)
A/J MGP_AJ_G0029134
protein coding gene Chr4:149561989-149573646 (-)
AKR/J MGP_AKRJ_G0029082
protein coding gene Chr4:153642951-153653512 (-)
BALB/cJ MGP_BALBcJ_G0029150
protein coding gene Chr4:150048789-150059779 (-)
C3H/HeJ MGP_C3HHeJ_G0028871
protein coding gene Chr4:154204984-154217431 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029599
protein coding gene Chr4:161709917-161720587 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026845
protein coding gene Chr4:141929456-141940578 (-)
CAST/EiJ MGP_CASTEiJ_G0028284
protein coding gene Chr4:151546375-151558332 (-)
CBA/J MGP_CBAJ_G0028833
protein coding gene Chr4:166525397-166537598 (-)
DBA/2J MGP_DBA2J_G0028982
protein coding gene Chr4:149623492-149635448 (-)
FVB/NJ MGP_FVBNJ_G0028946
protein coding gene Chr4:148780869-148793197 (-)
LP/J MGP_LPJ_G0029072
protein coding gene Chr4:156039355-156051332 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028973
protein coding gene Chr4:169569425-169581216 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029631
protein coding gene Chr4:154176880-154187542 (-)
PWK/PhJ MGP_PWKPhJ_G0028004
protein coding gene Chr4:145694448-145705375 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027838
protein coding gene Chr4:148455248-148469579 (-)
WSB/EiJ MGP_WSBEiJ_G0028364
protein coding gene Chr4:154339929-154350342 (-)



Homology
more
  • Human Ortholog
    TAS1R1, taste 1 receptor member 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TAS1R1, taste 1 receptor member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GM148, GPR70, T1R1, TR1
  • Links
    NCBI Gene ID: 80835
    neXtProt AC: NX_Q7RTX1
    UniProt: Q7RTX1

  • Chr Location
    1p36.31; chr1:6555278-6579757 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice show diminished behavioral and nervous responses to umami tastants. Response to sweet tastants is unimpaired.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110326 NCBI Gene Model | MGI Sequence Detail 10577 C57BL/6J ±  kb
    transcript NM_031867 RefSeq | MGI Sequence Detail 2814 C57BL/6  
    polypeptide Q99PG6 UniProt | EBI | MGI Sequence Detail 842 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 2
      cDNA 10
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1340021
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:53048 Hoon MA, et al., Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell. 1999 Feb 19;96(4):541-51
    • Latest
      J:294150 Murovets VO, et al., The Effect of the Taste Receptor Protein T1R3 on the Development of Islet Tissue of the Murine Pancreas. Dokl Biol Sci. 2019 May;484(1):1-4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    10/20/2020
    MGI 6.16
    The Jackson Laboratory