Rgs18
Gene Detail

Symbol Name ID

Rgs18 regulator of G-protein signaling 18 MGI:1927498

Feature Type

protein coding gene

Genetic Map

Chromosome 1

62.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:144752683-144775435 bp, - strand From VEGA annotation of GRCm38   22753 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11281  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs18

Human homologs

Human Homolog		RGS18, regulator of G-protein signaling 18
NCBI Gene ID		64407
neXtProt AC		NX_Q9NS28
Human Synonyms		RGS13
Human Chr (Location)		1q31.2; chr1:192127592-192154945 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(1) Chemically induced(1)

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	G-protein coupled receptor signaling pathway, negative regulation of signal transduction, ...
Component	cytoplasm, plasma membrane
Function	GTPase activator activity

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (45)    Tissues (15)   
Theiler Stages: 22

Assay Type	Results
Northern blot	45

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000026870 (Evidence)
Ensembl Gene Model	ENSMUSG00000026357 (Evidence)
Entrez Gene	64214 (Evidence)
UniGene	253927
DFCI	TC1585036, TC1724393
DoTS	DT.91338752
Consensus CDS Project	CCDS15350.1
International Mouse Knockout Project Status	Rgs18

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026870	VEGA Gene Model | MGI Sequence Detail	22753	C57BL/6J
transcript	OTTMUST00000066463	VEGA | MGI Sequence Detail	2031	Not Applicable
polypeptide	OTTMUSP00000033307	VEGA | MGI Sequence Detail	235	Not Applicable

All sequences(21) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(165 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024066	Regulator of G-protein signaling, domain 1
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
Protein Ontology	PR:000013952	regulator of G-protein signaling 18

References

(Earliest) J:65933 Park IK, et al., Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells. J Biol Chem. 2001 Jan 12;276(2):915-23
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(29)