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Rgs18 Gene Detail
Summary
  • Symbol
    Rgs18
  • Name
    regulator of G-protein signaling 18
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927498
    NCBI Gene: 64214
  • Gene Overview
    MyGene.info: RGS18
Location & Maps
more
  • Sequence Map
    Chr1:144752683-144775435 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22753 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RGS18, regulator of G-protein signaling 18
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RGS18, regulator of G-protein signaling 18
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RGS13
  • Links
    NCBI Gene ID: 64407
    neXtProt AC: NX_Q9NS28

  • Chr Location
    1q31.2; chr1:192158462-192187172 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Targeted
    2
  • Genomic Mutations
    2 involving Rgs18
  • Incidental Mutations
Homozygotes for a null allele show reduced thermal nociception threshold, increased startle reflex, thrombocytopenia, defective megakaryopoiesis, and increased platelet aggregation. Homozygotes for a different null allele show decreased bleeding time, increased platelet aggregation, and thrombosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026870 VEGA Gene Model | MGI Sequence Detail 22753 C57BL/6J ±  kb
transcript OTTMUST00000066463 VEGA | MGI Sequence Detail 2031 Not Applicable  
polypeptide OTTMUSP00000033307 VEGA | MGI Sequence Detail 235 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    211 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 26
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:65933 Park IK, et al., Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells. J Biol Chem. 2001 Jan 12;276(2):915-23
  • Latest
    J:228457 Alshbool FZ, et al., The regulator of G-protein signaling 18 regulates platelet aggregation, hemostasis and thrombosis. Biochem Biophys Res Commun. 2015 Jul 10;462(4):378-82

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory