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Rgs18
Gene Detail
Symbol

Name
ID
Rgs18
regulator of G-protein signaling 18
MGI:1927498
Feature Type
protein coding gene
Genetic Map
Chromosome 1
62.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:144752683-144775435 bp, - strand
From VEGA annotation of GRCm38

  22753 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11281  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RGS18
Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs18

Human
homologs
RGS18, regulator of G-protein signaling 18
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 64407
neXtProt AC: NX_Q9NS28

Human Synonyms: RGS13

Human Chr (Location): 1q31.2; chr1:192158462-192187172 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Chemically induced (ENU)(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Rgs18 interacts with 204 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process G-protein coupled receptor signaling pathway, negative regulation of signal transduction, ...
Component cytoplasm, plasma membrane
Function GTPase activator activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (45)    Tissues (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 45
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rgs18 ; ZFIN rgs18    NEW 
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000026870 (Evidence)
Ensembl Gene Model ENSMUSG00000026357 (Evidence)
Entrez Gene 64214 (Evidence)
UniGene 253927
DFCI TC1724393, TC1585036
DoTS DT.91338752
Consensus CDS Project CCDS15350.1
International Mouse Phenotyping Consortium Status Rgs18
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026870 VEGA Gene Model | MGI Sequence Detail 22753 C57BL/6J ±  kb
transcript OTTMUST00000066463 VEGA | MGI Sequence Detail 2031 Not Applicable 
polypeptide OTTMUSP00000033307 VEGA | MGI Sequence Detail 235 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(213 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR016137 Regulator of G protein signalling superfamily
Protein Ontology PR:000013952 regulator of G-protein signaling 18
References
(Earliest) J:65933 Park IK, et al., Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells. J Biol Chem. 2001 Jan 12;276(2):915-23
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory