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Pdlim5 Gene Detail
Summary
  • Symbol
    Pdlim5
  • Name
    PDZ and LIM domain 5
  • Synonyms
    1110001A05Rik, Enh, Enh2, Enh3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927489
    NCBI Gene: 56376
  • Gene Overview
    MyGene.info: PDLIM5
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:142239590-142395696 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 66.69 cM, cytoband H3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1882 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927489
protein coding gene Chr3:142239585-142395696 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027940
protein coding gene Chr3:145407019-145571538 (-)
A/J MGP_AJ_G0027897
protein coding gene Chr3:140268037-140424710 (-)
AKR/J MGP_AKRJ_G0027863
protein coding gene Chr3:143973056-144130983 (-)
BALB/cJ MGP_BALBcJ_G0027909
protein coding gene Chr3:140074077-140233491 (-)
C3H/HeJ MGP_C3HHeJ_G0027639
protein coding gene Chr3:144324032-144481334 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028353
protein coding gene Chr3:150476335-150637022 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025691
protein coding gene Chr3:135510561-135670039 (-)
CAST/EiJ MGP_CASTEiJ_G0027095
protein coding gene Chr3:144230994-144401418 (-)
CBA/J MGP_CBAJ_G0027616
protein coding gene Chr3:155654846-155830269 (-)
DBA/2J MGP_DBA2J_G0027755
protein coding gene Chr3:139397966-139560632 (-)
FVB/NJ MGP_FVBNJ_G0027722
protein coding gene Chr3:136818041-136981154 (-)
LP/J MGP_LPJ_G0027865
protein coding gene Chr3:146852133-147013785 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027754
protein coding gene Chr3:163957528-164148797 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028411
protein coding gene Chr3:143585511-143744301 (-)
PWK/PhJ MGP_PWKPhJ_G0026819
protein coding gene Chr3:139199437-139362778 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026646
protein coding gene Chr3:141696140-141860603 (-)
WSB/EiJ MGP_WSBEiJ_G0027174
protein coding gene Chr3:144447052-144608949 (-)



Homology
more
  • Human Ortholog
    PDLIM5, PDZ and LIM domain 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDLIM5, PDZ and LIM domain 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ENH, ENH1, L9, LIM
  • Links
    NCBI Gene ID: 10611
    neXtProt AC: NX_Q96HC4
    UniProt: Q96HC4

  • Chr Location
    4q22.3; chr4:94451857-94668227 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Pdlim5 mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired cardiac muscle contractility, wider Z-lines, and dilated cardiomyopathy. Mice heterozygous for a gene trap allele exhibit impaired response to methamphetamine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028273 Ensembl Gene Model | MGI Sequence Detail 156107 C57BL/6J ±  kb
    transcript ENSMUST00000195975 Ensembl | MGI Sequence Detail 1845 Not Applicable  
    polypeptide ENSMUSP00000142737 Ensembl | MGI Sequence Detail 614 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 23
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1914158, MGI:1927491, MGI:1927492, MGI:2139847, MGI:2140101
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 6
      Diseases 2
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:258855 Qiu H, et al., MicroRNA-17-92 regulates myoblast proliferation and differentiation by targeting the ENH1/Id1 signaling axis. Cell Death Differ. 2016 Oct;23(10):1658-69

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory