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Pdlim5
Gene Detail
Symbol

Name
ID
Pdlim5
PDZ and LIM domain 5
MGI:1927489
Synonyms
1110001A05Rik, Enh, Enh2, Enh3
Feature Type
protein coding gene
Genetic Map
Chromosome 3
66.69 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:142239590-142395693 bp, - strand
From VEGA annotation of GRCm38

  156104 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21289  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PDLIM5
Gene Tree: Pdlim5

Human
homologs
PDLIM5, PDZ and LIM domain 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10611
neXtProt AC: NX_Q96HC4

Human Synonyms: ENH, ENH1, L9, LIM

Human Chr (Location): 4q22; chr4:94451857-94668227 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(26) Targeted(4)
Incidental mutations (data from CvDC )
 
Mice homozygous for a knock-out allele exhibit impaired cardiac muscle contractility, wider Z-lines, and dilated cardiomyopathy. Mice heterozygous for a gene trap allele exhibit impaired response to methamphetamine.
 
Interactions
Pdlim5 interacts with 348 markers (Mir1b, Mir7-1, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell growth involved in cardiac muscle cell development, regulation of dendritic spine morphogenesis, ...
Component actin cytoskeleton, cell junction, ...
Function actin binding, actinin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (151)    Tissues (52)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 137
RT-PCR 8
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PDLIM5 ; Xenbase pdlim5    NEW 
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000053833 (Evidence)
Ensembl Gene Model ENSMUSG00000028273 (Evidence)
Entrez Gene 56376 (Evidence)
NIA Mouse Gene Index U024713, U275171
PDB 1WF7
Consensus CDS Project CCDS17875.1, CCDS17876.1, CCDS38656.1, CCDS57258.1, CCDS80035.1, CCDS80036.1, CCDS80037.1, CCDS80038.1, CCDS80039.1
International Mouse Phenotyping Consortium Status Pdlim5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053833 VEGA Gene Model | MGI Sequence Detail 156104 C57BL/6J ±  kb
transcript OTTMUST00000133974 VEGA | MGI Sequence Detail 1845 Not Applicable 
polypeptide OTTMUSP00000071125 VEGA | MGI Sequence Detail 614 Not Applicable 

For the selected sequences
All sequences(122) RefSeq(44) UniProt(13)
Polymorphisms
SNPs within 2kb(1888 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000012511 PDZ and LIM domain protein 5
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:200039 Horiuchi Y, et al., Experimental evidence for the involvement of PDLIM5 in mood disorders in hetero knockout mice. PLoS One. 2013;8(4):e59320
All references(45)
Other
accession IDs
MGI:1914158, MGI:1927491, MGI:1927492, MGI:2139847, MGI:2140101

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory