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Lsr
Gene Detail
Symbol

Name
ID
Lsr
lipolysis stimulated lipoprotein receptor
MGI:1927471
Synonyms
ILDR3, Lisch7
Feature Type
protein coding gene
Genetic Map
Chromosome 7
19.27 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:30957775-30973464 bp, - strand
From VEGA annotation of GRCm38

  15690 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9306  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Lsr

Human
homologs
Human Homolog LSR, lipolysis stimulated lipoprotein receptor
NCBI Gene ID 51599
neXtProt AC  NX_Q86X29
Human Synonyms  ILDR3, LISCH7
Human Chr (Location)  19q13.12; chr19:35248656-35267964 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality during fetal growth and development, liver hypoplasia, and variable penetrance of pallor, hemorrhaging, superficial skin detachment, and reduced size.
 
Interactions
Lsr interacts with 15 markers (Mir149, Mir185, Mir300, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (257)    Tissues (92)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 235
RT-PCR 22
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(8) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022193 (Evidence)
Ensembl Gene ModelENSMUSG00000001247 (Evidence)
Entrez Gene54135 (Evidence)
DFCITC1576724, TC1637700
Consensus CDS ProjectCCDS21119.1, CCDS52185.1, CCDS52186.1
International Mouse Knockout Project StatusLsr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022193 VEGA Gene Model | MGI Sequence Detail 15690 C57BL/6J ±  kb
transcript OTTMUST00000052721 VEGA | MGI Sequence Detail 2167 Not Applicable 
polypeptide OTTMUSP00000025036 VEGA | MGI Sequence Detail 594 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR008664 LISCH7
Protein Ontology PR:000009968 lipolysis-stimulated lipoprotein receptor
References
(Earliest) J:20532 Lin Q, et al., Archaic structure of the gene encoding transcription factor USF. J Biol Chem. 1994 Sep 30;269(39):23894-903
(Latest) J:190562 Stenger C, et al., Brain region-specific immunolocalization of the lipolysis-stimulated lipoprotein receptor (LSR) and altered cholesterol distribution in aged LSR+/- mice. J Neurochem. 2012 Nov;123(4):467-76
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory