About   Help   FAQ
Lsr
Gene Detail
 Symbol
Name
ID
Lsr
lipolysis stimulated lipoprotein receptor
MGI:1927471
Synonyms ILDR3, Lisch7
Feature Type protein coding gene
Genetic Map
Chromosome 7
19.27 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:30957775-30973464 bp, - strand
From VEGA annotation of GRCm38

  15690 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9306  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Lsr

Human
homologs
Human Homolog LSR, lipolysis stimulated lipoprotein receptor
NCBI Gene ID 51599
neXtProt AC  NX_Q86X29
Human Synonyms  ILDR3, LISCH7
Human Chr (Location)  19q13.12; chr19:35248656-35267964 (+)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality during fetal growth and development, liver hypoplasia, and variable penetrance of pallor, hemorrhaging, superficial skin detachment, and reduced size.
 
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process embryo development, lipoprotein transport, ...
Component chylomicron, extracellular vesicular exosome, ...
Function lipoprotein particle receptor activity, low-density lipoprotein particle binding
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (272)    Tissues (97)    Images (34)
Theiler Stages: 1, 2, 3, 4, 5, 15, 17, 19, 20, 21, 23, 27, 28
Assay TypeResults
RNA in situ 235
RT-PCR 37
cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(12) cDNA(8) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022193 (Evidence)
Ensembl Gene ModelENSMUSG00000001247 (Evidence)
Entrez Gene54135 (Evidence)
DFCITC1576724, TC1637700
Consensus CDS ProjectCCDS21119.1, CCDS52185.1, CCDS52186.1
International Mouse Knockout Project StatusLsr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022193 VEGA Gene Model | MGI Sequence Detail 15690 C57BL/6J ±  kb
transcript OTTMUST00000052721 VEGA | MGI Sequence Detail 2167 Not Applicable 
polypeptide OTTMUSP00000025036 VEGA | MGI Sequence Detail 594 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR008664 LISCH7
Protein Ontology PR:000009968 lipolysis-stimulated lipoprotein receptor
References (Earliest) J:20532 Lin Q, et al., Archaic structure of the gene encoding transcription factor USF. J Biol Chem. 1994 Sep 30;269(39):23894-903
(Latest) J:190562 Stenger C, et al., Brain region-specific immunolocalization of the lipolysis-stimulated lipoprotein receptor (LSR) and altered cholesterol distribution in aged LSR+/- mice. J Neurochem. 2012 Nov;123(4):467-76
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory