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Spag5 Gene Detail
Summary
  • Symbol
    Spag5
  • Name
    sperm associated antigen 5
  • Synonyms
    Astrin, D11Bhm180e, Deepest, MAP126, Mastrin, s17, S17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927470
    NCBI Gene: 54141
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:78192412-78213283 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 46.74 cM, cytoband B5
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    498 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927470
 protein coding gene Chr11:78192355-78213283 (+)
129S1/SvImJ ENSMUSG00200049613
 protein coding gene Chr11:75309230-75330155 (+)
A/J ENSMUSG00195038194
 protein coding gene Chr11:75188027-75208955 (+)
AKR/J ENSMUSG00220046389
 protein coding gene Chr11:75411950-75432878 (+)
BALB/cJ ENSMUSG00180041003
 protein coding gene Chr11:75376804-75397732 (+)
C3H/HeJ ENSMUSG00175037575
 protein coding gene Chr11:75346038-75366965 (+)
C57BL/6NJ ENSMUSG00215041107
 protein coding gene Chr11:74970048-74990981 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016800
 protein coding gene Chr11:73240829-73261622 (+)
CAST/EiJ ENSTCUG00005044861
 protein coding gene Chr11:74869364-74890341 (+)
CBA/J ENSMUSG00210036149
 protein coding gene Chr11:75164468-75185395 (+)
DBA/2J ENSMUSG00185032893
 protein coding gene Chr11:75434495-75455420 (+)
FVB/NJ ENSMUSG00205031264
 protein coding gene Chr11:75264075-75285005 (+)
JF1/MsJ ENSUMUG00000030098
 protein coding gene Chr11:75813367-75834437 (+)
LP/J ENSMUSG00230044018
 protein coding gene Chr11:76464956-76485880 (+)
NOD/ShiLtJ ENSMUSG00190039077
 protein coding gene Chr11:75481547-75502474 (+)
NZO/HlLtJ ENSMUSG00225037007
 protein coding gene Chr11:78632439-78653368 (+)
PWK/PhJ ENSLUMG00010020153
 protein coding gene Chr11:75338888-75359671 (+)
SPRET/EiJ ENSMSPG00010035051
 protein coding gene Chr11:75750064-75770917 (+)
WSB/EiJ ENSIUOG00005028932
 protein coding gene Chr11:75319713-75340645 (+)



Homology
more
  • Human Ortholog
    SPAG5, sperm associated antigen 5
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPAG5, sperm associated antigen 5
  • Synonyms
    DEEPEST, hMAP126, MAP126
  • Links
    NCBI Gene ID: 10615
    UniProt: Q96R06

  • Chr Location
    17q11.2; chr17:28577565-28599025 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    17 phenotype references
Mice homozygous for a targeted mutation are viable and fertile with normal breeding and mating behavio; no abnormalities in male reproductive system anatomy or histology or in spermatogenesis were detectable.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    753
  • Tissues
    140
  • cDNA Data
    9
  • Literature Summary
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54141 NCBI Gene Model | MGI Sequence Detail 20872 C57BL/6J ±  kb
transcript NR_156178 RefSeq | MGI Sequence Detail 3852 ZRU/MplStud  
polypeptide Q7TME2 UniProt | EBI | MGI Sequence Detail 1165 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 5
    cDNA 10
    Primer pair 3
    Other 1
    Antibodies 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-35274, MGI:106814, MGI:2144324
References
more
  • Summaries
    All 57
    Developmental Gene Expression 11
    Gene Ontology 9
    Phenotypes 17
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:327275 Mora-Bermudez F, et al., Longer metaphase and fewer chromosome segregation errors in modern human than Neanderthal brain development. Sci Adv. 2022 Jul 29;8(30):eabn7702
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory