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Spag5 Gene Detail
Summary
  • Symbol
    Spag5
  • Name
    sperm associated antigen 5
  • Synonyms
    Astrin, D11Bhm180e, Deepest, MAP126, Mastrin, s17, S17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927470
    NCBI Gene: 54141
  • Gene Overview
    MyGene.info: SPAG5
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:78301529-78322457 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM, cytoband B5
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927470
protein coding gene Chr11:78300528-78322457 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018774
protein coding gene Chr11:79294522-79317744 (+)
A/J MGP_AJ_G0018740
protein coding gene Chr11:76264368-76285718 (+)
AKR/J MGP_AKRJ_G0018710
protein coding gene Chr11:78569163-78591160 (+)
BALB/cJ MGP_BALBcJ_G0018714
protein coding gene Chr11:76672365-76694406 (+)
C3H/HeJ MGP_C3HHeJ_G0018527
protein coding gene Chr11:78609970-78631062 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019165
protein coding gene Chr11:81767681-81791286 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016800
protein coding gene Chr11:73240829-73261622 (+)
CAST/EiJ MGP_CASTEiJ_G0018081
protein coding gene Chr11:79058469-79080538 (+)
CBA/J MGP_CBAJ_G0018497
protein coding gene Chr11:85345890-85371407 (+)
DBA/2J MGP_DBA2J_G0018606
protein coding gene Chr11:75843229-75863881 (+)
FVB/NJ MGP_FVBNJ_G0018596
protein coding gene Chr11:75432305-75452648 (+)
LP/J MGP_LPJ_G0018677
protein coding gene Chr11:79830873-79852847 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018622
protein coding gene Chr11:85750221-85776384 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019205
protein coding gene Chr11:78813414-78838845 (+)
PWK/PhJ MGP_PWKPhJ_G0017852
protein coding gene Chr11:76630693-76652291 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017643
protein coding gene Chr11:78427157-78449974 (+)
WSB/EiJ MGP_WSBEiJ_G0018134
protein coding gene Chr11:78633686-78659390 (+)



Homology
more
  • Human Ortholog
    SPAG5, sperm associated antigen 5
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SPAG5, sperm associated antigen 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DEEPEST, hMAP126, MAP126
  • Links
    NCBI Gene ID: 10615
    neXtProt AC: NX_Q96R06
    UniProt: Q96R06

  • Chr Location
    17q11.2; chr17:28577565-28599038 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
Mice homozygous for a targeted mutation are viable and fertile with normal breeding and mating behavio; no abnormalities in male reproductive system anatomy or histology or in spermatogenesis were detectable.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002055 Ensembl Gene Model | MGI Sequence Detail 20929 C57BL/6J ±  kb
transcript ENSMUST00000045026 Ensembl | MGI Sequence Detail 3887 Not Applicable  
polypeptide ENSMUSP00000045286 Ensembl | MGI Sequence Detail 1165 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 18
    Genomic 5
    cDNA 10
    Primer pair 2
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-35274, MGI:106814, MGI:2144324
References
more
  • Summaries
    All 46
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:196507 Kersten FF, et al., The mitotic spindle protein SPAG5/Astrin connects to the Usher protein network postmitotically. Cilia. 2012;1(1):2

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory