St7 MGI Mouse Gene Detail - MGI:1927450 - suppression of tumorigenicity 7

Symbol

St7
Name

suppression of tumorigenicity 7
Synonyms

9430001H04Rik, Fam4a2, HELG, RAY1, SEN4, TSG7

Feature Type

protein coding gene
IDs

MGI:1927450
NCBI Gene: 64213
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr6:17693579-17943022 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 8.00 cM, cytoband A2
Mapping Data

2 experiments

SNPs within 2kb

6624 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927450	protein coding gene	Chr6:17692932-17943024 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030472	protein coding gene	Chr6:14952507-15219807 (+)
A/J	MGP_AJ_G0030445	protein coding gene	Chr6:14343168-14595152 (+)
AKR/J	MGP_AKRJ_G0030372	protein coding gene	Chr6:14838547-15098837 (+)
BALB/cJ	MGP_BALBcJ_G0030454	protein coding gene	Chr6:14433143-14693776 (+)
C3H/HeJ	MGP_C3HHeJ_G0030168	protein coding gene	Chr6:14709853-14977933 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030909	protein coding gene	Chr6:15414747-15695376 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028120	protein coding gene	Chr6:13304513-13545208 (+)
CAST/EiJ	MGP_CASTEiJ_G0029570	protein coding gene	Chr6:14618800-14888885 (+)
CBA/J	MGP_CBAJ_G0030146	protein coding gene	Chr6:15918525-16203053 (+)
DBA/2J	MGP_DBA2J_G0030290	protein coding gene	Chr6:14276245-14532229 (+)
FVB/NJ	MGP_FVBNJ_G0030244	protein coding gene	Chr6:14110875-14360790 (+)
LP/J	MGP_LPJ_G0030377	protein coding gene	Chr6:15038050-15318958 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030280	protein coding gene	Chr6:17099083-17363840 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030939	protein coding gene	Chr6:14727018-14989927 (+)
PWK/PhJ	MGP_PWKPhJ_G0029284	protein coding gene	Chr6:13927021-14187898 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029120	protein coding gene	Chr6:14607736-14878911 (+)
WSB/EiJ	MGP_WSBEiJ_G0029646	protein coding gene	Chr6:14666730-14926865 (+)

Human Ortholog

ST7, suppression of tumorigenicity 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ST7, suppression of tumorigenicity 7
Synonyms

ETS7q, FAM4A, FAM4A1, HELG, RAY1, SEN4, TSG7
Links

HGNC:11351

NCBI Gene ID: 7982

UniProt: Q9NRC1
Chr Location

7q31.2; chr7:116953238-117230176 (+) GRCh38

MGI Vertebrate Homology

St7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ST7
Gene Tree

St7

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

7
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

54 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

3
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

775
Tissues

18
cDNA Data

32
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase st7

ZFIN st7

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All Sequences

117
RefSeq

27
UniProt

7
CCDS

CCDS19927.1, CCDS39431.1, CCDS71728.1, CCDS71729.1, CCDS71730.1, CCDS71731.1, CCDS80490.1

Ensembl

ENSMUSG00000029534 (Evidence)
NCBI Gene

64213

			Length	Strain/Species	Flank
genomic	64213	NCBI Gene Model \| MGI Sequence Detail	249444	C57BL/6J	± kb
transcript	NM_022332	RefSeq \| MGI Sequence Detail	2286	C57BL/6
polypeptide	Q99M96	UniProt \| EBI \| MGI Sequence Detail	577	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000015693 suppressor of tumorigenicity 7 protein

(term hierarchy)
InterPro Domains

IPR007311 ST7
GlyGen

Q99M96 1 site

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All nucleic 34

cDNA 32

Primer pair 2

Microarray probesets 2

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MGI:1924509

Summaries

All 37

Developmental Gene Expression 5

Gene Ontology 3

Phenotypes 7
Earliest

J:63711 Vincent JB, et al., Identification of a novel gene on chromosome 7q31 that is interrupted by a translocation breakpoint in an autistic individual [see comments]. Am J Hum Genet. 2000 Aug;67(2):510-4
Latest

J:369747 Lin S, et al., Rbpms2 prevents major cardiac defects in cardiomyocyte-specific Rbpms-deficient mice. Dev Cell. 2025 Jun 24;

TSS for St7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr55085	Chr6:17693606-17693617 (+)	33 bp
Tssr55089	Chr6:17694050-17694090 (+)	491 bp
Tssr55090	Chr6:17694169-17694178 (+)	595 bp
Tssr55091	Chr6:17725341-17725345 (+)	31,764 bp
Tssr55092	Chr6:17731219-17731253 (+)	37,657 bp
Tssr55093	Chr6:17743581-17743592 (+)	50,008 bp
Tssr55094	Chr6:17743593-17743612 (+)	50,024 bp
Tssr55095	Chr6:17749002-17749021 (+)	55,433 bp
Tssr1786	Chr6:17749087-17749102 (+)	55,516 bp
Tssr55096	Chr6:17749139-17749150 (+)	55,566 bp
Tssr55097	Chr6:17749171-17749264 (+)	55,639 bp
Tssr55098	Chr6:17749567-17749571 (+)	55,990 bp
Tssr55099	Chr6:17762880-17762884 (+)	69,303 bp
Tssr55100	Chr6:17822962-17822987 (+)	129,396 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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