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Herpud1 Gene Detail
Summary
  • Symbol
    Herpud1
  • Name
    homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
  • Synonyms
    Herp, Mifl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927406
    NCBI Gene: 64209
  • Gene Overview
    MyGene.info: HERPUD1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:94386438-94395377 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8940 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 46.46 cM, cytoband C5
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    HERPUD1, homocysteine inducible ER protein with ubiquitin like domain 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HERPUD1, homocysteine inducible ER protein with ubiquitin like domain 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HERP, Mif1, SUP
  • Links
    NCBI Gene ID: 9709
    neXtProt AC: NX_Q15011
    UniProt: Q15011

  • Chr Location
    16q13; chr16:56932090-56943881 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 images
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired glucose tolerance and decreased cerebral infarction size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000027364 VEGA Gene Model | MGI Sequence Detail 8940 C57BL/6J ±  kb
    transcript OTTMUST00000067665 VEGA | MGI Sequence Detail 1952 Not Applicable  
    polypeptide OTTMUSP00000034083 VEGA | MGI Sequence Detail 391 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      102 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000008513 homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
    • InterPro Domains
      IPR000626 Ubiquitin domain
      IPR029071 Ubiquitin-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 244
      cDNA 242
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 5
    • Earliest
      J:65186 Kokame K, et al., Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress. J Biol Chem. 2000 Oct 20;275(42):32846-53
    • Latest
      J:253982 Norlin S, et al., The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Development. 2018 Jan 3;145(1):None

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory