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Rhbg
Gene Detail
 Symbol
Name
ID
Rhbg
Rhesus blood group-associated B glycoprotein
MGI:1927379
Feature Type protein coding gene
Genetic Map
Chromosome 3
38.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:88242874-88287210 bp, - strand
From VEGA annotation of GRCm38

  44337 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9469  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: erythrocyte membrane protein RhD
Gene Tree: Rhbg

Human
homologs
Human Homolog RHBG, Rh family, B glycoprotein (gene/pseudogene)
NCBI Gene ID 57127
neXtProt AC  NX_Q9H310
Human Synonyms  SLC42A2
Human Chr (Location)  1q21.3; chr1:156369189-156385221 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(151) : Gene trapped(147) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable, do not develop hyperammonemic hepatic encephalopathy or distal tubular acidosis, and show a normal renal response to chronic acid-loading and no changes in NH4+ or NH3 entry across the basolateral membrane of cortical collecting ducts cells.
 
Interactions
Rhbg interacts with 77 markers (Mir26a-1, Mir34a, Mir34b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process ammonium transmembrane transport, ammonium transport, ...
Component anchored component of plasma membrane, basolateral plasma membrane, ...
Function ammonium transmembrane transporter activity, ankyrin binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (151)    Tissues (151)    Images (4)
Theiler Stages: 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 151
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000035936 (Evidence)
Ensembl Gene ModelENSMUSG00000001417 (Evidence)
Entrez Gene58176 (Evidence)
UniGene103777
DFCITC1584625
DoTSDT.482501
NIA Mouse Gene IndexU024247
Consensus CDS ProjectCCDS17466.1
International Mouse Knockout Project StatusRhbg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035936 VEGA Gene Model | MGI Sequence Detail 44337 C57BL/6J ±  kb
transcript OTTMUST00000092181 VEGA | MGI Sequence Detail 1937 Not Applicable 
polypeptide OTTMUSP00000050888 VEGA | MGI Sequence Detail 455 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(136 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024041 Ammonium transporter AmtB-like domain
InterPro IPR002229 Blood group Rhesus C/E/D polypeptide
Protein Ontology PR:000013973 ammonium transporter Rh type B
References (Earliest) J:63941 Liu Z, et al., Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis. J Biol Chem. 2000 Aug 18;275(33):25641-51
(Latest) J:206295 Lee HW, et al., Effect of collecting duct-specific deletion of both Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) on renal response to metabolic acidosis. Am J Physiol Renal Physiol. 2014 Feb;306(4):F389-400
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory