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Rhbg Gene Detail
Summary
  • Symbol
    Rhbg
  • Name
    Rhesus blood group-associated B glycoprotein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927379
    NCBI Gene: 58176
  • Gene Overview
    MyGene.info: RHBG
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:88242874-88254709 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.78 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    79 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927379
protein coding gene Chr3:88242874-88254740 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027385
protein coding gene Chr3:88391152-88402987 (-)
A/J MGP_AJ_G0027349
protein coding gene Chr3:85393530-85405365 (-)
AKR/J MGP_AKRJ_G0027315
protein coding gene Chr3:87488392-87500225 (-)
BALB/cJ MGP_BALBcJ_G0027358
protein coding gene Chr3:85483699-85495534 (-)
C3H/HeJ MGP_C3HHeJ_G0027101
protein coding gene Chr3:87774600-87786435 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027804
protein coding gene Chr3:91641835-91653670 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025157
protein coding gene Chr3:81017188-81028836 (-)
CAST/EiJ MGP_CASTEiJ_G0026547
protein coding gene Chr3:87983930-87995640 (-)
CBA/J MGP_CBAJ_G0027076
protein coding gene Chr3:94766835-94778670 (-)
DBA/2J MGP_DBA2J_G0027212
protein coding gene Chr3:84880653-84892488 (-)
FVB/NJ MGP_FVBNJ_G0027181
protein coding gene Chr3:83153397-83165232 (-)
LP/J MGP_LPJ_G0027320
protein coding gene Chr3:89358138-89369973 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027200
protein coding gene Chr3:100997509-101009344 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027862
protein coding gene Chr3:87248342-87260177 (-)
PWK/PhJ MGP_PWKPhJ_G0026280
protein coding gene Chr3:84677262-84689660 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026098
protein coding gene Chr3:86427276-86439086 (-)
WSB/EiJ MGP_WSBEiJ_G0026627
protein coding gene Chr3:87604866-87616699 (-)



Homology
more
  • Human Ortholog
    RHBG, Rh family B glycoprotein (gene/pseudogene)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RHBG, Rh family B glycoprotein (gene/pseudogene)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SLC42A2
  • Links
    NCBI Gene ID: 57127
    neXtProt AC: NX_Q9H310
    UniProt: Q9H310

  • Chr Location
    1q22; chr1:156366044-156385221 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, do not develop hyperammonemic hepatic encephalopathy or distal tubular acidosis, and show a normal renal response to chronic acid-loading and no changes in NH4+ or NH3 entry across the basolateral membrane of cortical collecting ducts cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000104445 Ensembl Gene Model | MGI Sequence Detail 11836 C57BL/6J ±  kb
    transcript ENSMUST00000171887 Ensembl | MGI Sequence Detail 1937 Not Applicable  
    polypeptide ENSMUSP00000130767 Ensembl | MGI Sequence Detail 455 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 2
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 12
      Phenotypes 11
    • Earliest
      J:63941 Liu Z, et al., Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis. J Biol Chem. 2000 Aug 18;275(33):25641-51
    • Latest
      J:206295 Lee HW, et al., Effect of collecting duct-specific deletion of both Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) on renal response to metabolic acidosis. Am J Physiol Renal Physiol. 2014 Feb;306(4):F389-400

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory