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Smarce1
Gene Detail
Symbol

Name
ID
Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
MGI:1927347
Synonyms
2810417B20Rik, 5830412H02Rik, 9030408N19Rik, BAF57
Feature Type
protein coding gene
Genetic Map
Chromosome 11
62.92 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:99209047-99231017 bp, - strand
From VEGA annotation of GRCm38

  21971 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37727  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SMARCE1
Gene Tree: Smarce1

Human
homologs
SMARCE1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6605
neXtProt AC: NX_Q969G3

Human Synonyms: BAF57

Human Chr (Location): 17q21.2; chr17:40627720-40647851 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SMARCE1

Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(19) Targeted(7)
Genomic Mutations involving Smarce1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit prenatal lethality.
 
Interactions
Smarce1 interacts with 210 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process ATP-dependent chromatin remodeling, chromatin modification, ...
Component BAF-type complex, nBAF complex, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (102)    Tissues (95)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 85
Western blot 4
RT-PCR 13
cDNA source data(13)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA SMARCE1 ; Xenbase smarce1 ; ZFIN smarce1    NEW 
Molecular
reagents
All nucleic(17) cDNA(14) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000006455 (Evidence)
Ensembl Gene Model ENSMUSG00000037935 (Evidence)
Entrez Gene 57376 (Evidence)
DFCI TC1612805, TC1592479, TC1572232, TC1653777
DoTS DT.110521340, DT.94237863, DT.55148864, DT.494468
Consensus CDS Project CCDS25374.1
International Mouse Phenotyping Consortium Status Smarce1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006455 VEGA Gene Model | MGI Sequence Detail 21971 C57BL/6J ±  kb
transcript OTTMUST00000014750 VEGA | MGI Sequence Detail 2919 Not Applicable 
polypeptide OTTMUSP00000006855 VEGA | MGI Sequence Detail 411 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
Protein Ontology PR:000015268 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
References
(Earliest) J:45580 Wang W, et al., Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes. Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):492-8
(Latest) J:212358 Singh AP, et al., Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation. Nucleic Acids Res. 2014 Mar;42(5):2958-75
All references(53)
Other
accession IDs
MGI:1916518, MGI:1921785, MGI:1922002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory