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Gmnn
Gene Detail
 Symbol
Name
ID
Gmnn
geminin
MGI:1927344
Synonyms Gem
Feature Type protein coding gene
Genetic Map
Chromosome 13
10.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:24751845-24761923 bp, - strand
From VEGA annotation of GRCm38

  10079 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9292  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Geminin
Gene Tree: Gmnn

Human
homologs
Human Homolog GMNN, geminin, DNA replication inhibitor
NCBI Gene ID 51053
neXtProt AC  NX_O75496
Human Synonyms  Gem
Human Chr (Location)  6p22.3; chr6:24774931-24786099 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(18) Targeted(7)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit early embryonic lethality, defective inner cell mass formation, and endoreduplication.
 
Interactions
Gmnn interacts with 88 markers (Mir1b, Mir31, Mir33, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell cycle, negative regulation of cell cycle, ...
Component cytoplasm, nucleus
Function histone deacetylase binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (172)    Tissues (32)    Images (31)
Theiler Stages: 20, 23, 26, 27, 28
Assay TypeResults
RNA in situ 125
Northern blot 18
Western blot 23
RT-PCR 6
cDNA source data(81)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(84) Genomic(1) cDNA(82) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000000611 (Evidence)
Ensembl Gene ModelENSMUSG00000006715 (Evidence)
Entrez Gene57441 (Evidence)
UniGene12239
DFCITC1577494, TC1592467
DoTSDT.494958, DT.97363784
NIA Mouse Gene IndexU034626
PDB2ZXX
Consensus CDS ProjectCCDS26378.1
International Mouse Knockout Project StatusGmnn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000611 VEGA Gene Model | MGI Sequence Detail 10079 C57BL/6J ±  kb
transcript OTTMUST00000001212 VEGA | MGI Sequence Detail 963 Not Applicable 
polypeptide OTTMUSP00000000569 VEGA | MGI Sequence Detail 206 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(5)
Polymorphisms SNPs within 2kb(120 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022786 Geminin family
Protein Ontology PR:000008074 geminin
References (Earliest) J:49655 Kroll KL, et al., Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation. Development. 1998 Aug;125(16):3247-58
(Latest) J:208821 de Renty C, et al., The dual roles of geminin during trophoblast proliferation and differentiation. Dev Biol. 2014 Mar 1;387(1):49-63
All references(54)
Other
accession IDs
MGI:2145450

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory