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Gmnn Gene Detail
Summary
  • Symbol
    Gmnn
  • Name
    geminin
  • Synonyms
    Gem
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927344
    NCBI Gene: 57441
  • Gene Overview
    MyGene.info: GMNN
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:24751845-24761923 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10079 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 10.64 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    GMNN, geminin, DNA replication inhibitor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GMNN, geminin, DNA replication inhibitor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Gem, MGORS6
  • Links
    NCBI Gene ID: 51053
    neXtProt AC: NX_O75496
    UniProt: O75496

  • Chr Location
    6p22.3; chr6:24774931-24786099 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9292
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GMNN
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 6 alleles in 8 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit early embryonic lethality, defective inner cell mass formation, and endoreduplication.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000000611 VEGA Gene Model | MGI Sequence Detail 10079 C57BL/6J ±  kb
    transcript OTTMUST00000001213 VEGA | MGI Sequence Detail 1127 Not Applicable  
    polypeptide OTTMUSP00000000570 VEGA | MGI Sequence Detail 206 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      120 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 85
      Genomic 1
      cDNA 82
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145450
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 12
      Gene Ontology 8
      Phenotypes 27
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:256436 Sankar S, et al., Geminin deficiency enhances survival in a murine medulloblastoma model by inducing apoptosis of preneoplastic granule neuron precursors. Genes Cancer. 2017 Sep;8(9-10):725-744

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory