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Gmnn
Gene Detail
Symbol

Name
ID
Gmnn
geminin
MGI:1927344
Synonyms
Gem
Feature Type
protein coding gene
Genetic Map
Chromosome 13
10.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:24751845-24761923 bp, - strand
From VEGA annotation of GRCm38

  10079 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9292  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GMNN
Protein SuperFamily: Geminin
Gene Tree: Gmnn

Human
homologs
GMNN, geminin, DNA replication inhibitor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51053
neXtProt AC: NX_O75496

Human Synonyms: Gem

Human Chr (Location): 6p22.3; chr6:24774931-24786099 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(18) Radiation induced(1) Targeted(7)
Genomic Mutations involving Gmnn (1)
Incidental mutations (data from APF , CvDC )
 
Homozygotes for targeted null mutations exhibit early embryonic lethality, defective inner cell mass formation, and endoreduplication.
 
Interactions
Gmnn interacts with 87 markers (Mir1b, Mir31, Mir33, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell cycle, negative regulation of cell cycle, ...
Component cytoplasm, nucleus
Function histone deacetylase binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (172)    Tissues (32)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 125
Northern blot 18
Western blot 23
RT-PCR 6
cDNA source data(81)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA GMNN ; Xenbase gmnn ; ZFIN gmnn    NEW 
Molecular
reagents
All nucleic(84) Genomic(1) cDNA(82) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000000611 (Evidence)
Ensembl Gene Model ENSMUSG00000006715 (Evidence)
Entrez Gene 57441 (Evidence)
UniGene 12239
DFCI TC1577494, TC1592467
DoTS DT.494958, DT.97363784
NIA Mouse Gene Index U034626
PDB 2ZXX
Consensus CDS Project CCDS26378.1
International Mouse Phenotyping Consortium Status Gmnn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000611 VEGA Gene Model | MGI Sequence Detail 10079 C57BL/6J ±  kb
transcript OTTMUST00000001212 VEGA | MGI Sequence Detail 963 Not Applicable 
polypeptide OTTMUSP00000000569 VEGA | MGI Sequence Detail 206 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(120 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022786 Geminin family
Protein Ontology PR:000008074 geminin
References
(Earliest) J:49655 Kroll KL, et al., Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation. Development. 1998 Aug;125(16):3247-58
(Latest) J:217678 Karamitros D, et al., Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors. Development. 2015 Jan 1;142(1):70-81
All references(55)
Other
accession IDs
MGI:2145450

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory