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Gmnn Gene Detail
Summary
  • Symbol
    Gmnn
  • Name
    geminin
  • Synonyms
    Gem
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927344
    NCBI Gene: 57441
  • Gene Overview
    MyGene.info: GMNN
Location & Maps
more
  • Sequence Map
    Chr13:24751845-24761923 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10079 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 10.64 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    GMNN, geminin, DNA replication inhibitor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GMNN, geminin, DNA replication inhibitor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Gem, MGORS6
  • Links
    NCBI Gene ID: 51053
    neXtProt AC: NX_O75496

  • Chr Location
    6p22.3; chr6:24774931-24786099 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9292
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: GMNN
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human GMNN associations

Human Disease Mouse Models
       Meier-Gorlin Syndrome 6; MGORS6   OMIM: 616835
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 6 alleles in 8 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (other)
    1
  • Gene trapped
    18
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Gmnn
  • Incidental Mutations
    APF , CvDC
Homozygotes for targeted null mutations exhibit early embryonic lethality, defective inner cell mass formation, and endoreduplication.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000611 VEGA Gene Model | MGI Sequence Detail 10079 C57BL/6J ±  kb
transcript OTTMUST00000001212 VEGA | MGI Sequence Detail 963 Not Applicable  
polypeptide OTTMUSP00000000569 VEGA | MGI Sequence Detail 206 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    120 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 84
    Genomic 1
    cDNA 82
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145450
References
more
  • Summaries
    All 54
    Developmental Gene Expression 11
    Gene Ontology 8
    Phenotypes 25
  • Earliest
    J:49655 Kroll KL, et al., Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation. Development. 1998 Aug;125(16):3247-58
  • Latest
    J:228873 Stathopoulou A, et al., Inactivation of Geminin in neural crest cells affects the generation and maintenance of enteric progenitor cells, leading to enteric aganglionosis. Dev Biol. 2016 Jan 15;409(2):392-405

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory