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Gmnn Gene Detail
Summary
  • Symbol
    Gmnn
  • Name
    geminin
  • Synonyms
    Gem
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927344
    NCBI Gene: 57441
  • Gene Overview
    MyGene.info: GMNN
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:24751845-24761923 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 10.64 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    120 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927344
protein coding gene Chr13:24751845-24761937 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020379
protein coding gene Chr13:22242462-22252502 (-)
A/J MGP_AJ_G0020328
protein coding gene Chr13:21822709-21832866 (-)
AKR/J MGP_AKRJ_G0020308
protein coding gene Chr13:22073325-22083398 (-)
BALB/cJ MGP_BALBcJ_G0020326
protein coding gene Chr13:21819475-21829557 (-)
C3H/HeJ MGP_C3HHeJ_G0020130
protein coding gene Chr13:22157867-22167911 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020763
protein coding gene Chr13:23041641-23053906 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018351
protein coding gene Chr13:20564843-20575106 (-)
CAST/EiJ MGP_CASTEiJ_G0019647
protein coding gene Chr13:21870402-21881355 (-)
CBA/J MGP_CBAJ_G0020084
protein coding gene Chr13:23915565-23925638 (-)
DBA/2J MGP_DBA2J_G0020210
protein coding gene Chr13:21340846-21350924 (-)
FVB/NJ MGP_FVBNJ_G0020194
protein coding gene Chr13:20976712-20986973 (-)
LP/J MGP_LPJ_G0020283
protein coding gene Chr13:22548656-22558726 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020221
protein coding gene Chr13:24176858-24186932 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020805
protein coding gene Chr13:21934355-21944421 (-)
PWK/PhJ MGP_PWKPhJ_G0019401
protein coding gene Chr13:21360266-21370656 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019217
protein coding gene Chr13:20752146-20763683 (-)
WSB/EiJ MGP_WSBEiJ_G0019707
protein coding gene Chr13:22088721-22105125 (-)



Homology
more
  • Human Ortholog
    GMNN, geminin, DNA replication inhibitor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GMNN, geminin, DNA replication inhibitor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Gem, MGORS6
  • Links
    NCBI Gene ID: 51053
    neXtProt AC: NX_O75496
    UniProt: O75496

  • Chr Location
    6p22.3; chr6:24774931-24786099 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9292
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GMNN
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 6 alleles in 8 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit early embryonic lethality, defective inner cell mass formation, and endoreduplication.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006715 Ensembl Gene Model | MGI Sequence Detail 10079 C57BL/6J ±  kb
    transcript ENSMUST00000006898 Ensembl | MGI Sequence Detail 1127 Not Applicable  
    polypeptide ENSMUSP00000006898 Ensembl | MGI Sequence Detail 206 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 86
      Genomic 1
      cDNA 83
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145450
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 12
      Gene Ontology 8
      Phenotypes 27
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:256436 Sankar S, et al., Geminin deficiency enhances survival in a murine medulloblastoma model by inducing apoptosis of preneoplastic granule neuron precursors. Genes Cancer. 2017 Sep;8(9-10):725-744

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory