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Rps6kb2 Gene Detail
Summary
  • Symbol
    Rps6kb2
  • Name
    ribosomal protein S6 kinase, polypeptide 2
  • Synonyms
    S6K2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927343
    NCBI Gene: 58988
  • Gene Overview
    MyGene.info: RPS6KB2
Location & Maps
more
  • Genetic Map
    Chromosome 19, 3.86 cM, cytoband A
  • Mapping Data
    2 experiments
Homology
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  • Human Ortholog
    RPS6KB2, ribosomal protein S6 kinase B2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    RPS6KB2, ribosomal protein S6 kinase B2
    Orthology source: HomoloGene
  • Synonyms
    KLS, P70-beta, P70-beta-1, P70-beta-2, p70S6Kb, p70(S6K)-beta, S6K2, S6K-beta2, SRK, STK14B
  • Links
    NCBI Gene ID: 6199
    neXtProt AC: NX_Q9UBS0

  • Chr Location
    11q13.2; chr11:67428460-67435408 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    18 phenotypes from multigenic genotypes
    19 phenotype references
Mice homozygous for a null allele exhibit no obvious abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028311 VEGA Gene Model | MGI Sequence Detail 6642 C57BL/6J ±  kb
transcript OTTMUST00000070162 VEGA | MGI Sequence Detail 1864 Not Applicable  
polypeptide OTTMUSP00000035727 VEGA | MGI Sequence Detail 485 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    54 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 8
    cDNA 8

    Microarray probesets 3
References
more
  • Summaries
    All 52
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 19
  • Earliest
    J:52107 Shima H, et al., Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J. 1998 Nov 16;17(22):6649-59
  • Latest
    J:212082 Lebrun-Julien F, et al., Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination. J Neurosci. 2014 Jun 18;34(25):8432-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory