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Sv2b Gene Detail
Summary
  • Symbol
    Sv2b
  • Name
    synaptic vesicle glycoprotein 2 b
  • Synonyms
    A830038F04Rik, mKIAA0735
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927338
    NCBI Gene: 64176
  • Gene Overview
    MyGene.info: SV2B
Location & Maps
more
  • Sequence Map
    Chr7:75114894-75309262 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      194369 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 43.62 cM, cytoband D1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SV2B, synaptic vesicle glycoprotein 2B
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SV2B, synaptic vesicle glycoprotein 2B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HsT19680
  • Links
    NCBI Gene ID: 9899
    neXtProt AC: NX_Q7L1I2

  • Chr Location
    15q26.1; chr15:91099721-91301309 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Sv2b
  • Incidental Mutations
Homozygotes for a targeted null mutation are phenotypically normal, and Sv2a/Sv2b double knockouts are no more affected than Sv2a single knockouts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058388 VEGA Gene Model | MGI Sequence Detail 194369 C57BL/6J ±  kb
transcript OTTMUST00000143406 VEGA | MGI Sequence Detail 5524 Not Applicable  
polypeptide OTTMUSP00000074762 VEGA | MGI Sequence Detail 683 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1745 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015850 synaptic vesicle glycoprotein 2B
  • InterPro Domains
    IPR005828 Major facilitator, sugar transporter-like
    IPR011701 Major facilitator superfamily
    IPR020846 Major facilitator superfamily domain
    IPR001646 Pentapeptide repeat
    IPR005829 Sugar transporter, conserved site
    IPR022308 Synaptic vesicle protein SV2
Molecular
Reagents
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  • All nucleic 36
    cDNA 36

    Microarray probesets 4
Other
Accession IDs
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MGI:2142055, MGI:2443605
References
more
  • Summaries
    All 67
    Developmental Gene Expression 27
    Gene Ontology 5
    Phenotypes 27
  • Earliest
    J:33098 Gautam M, et al., Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell. 1996 May 17;85(4):525-35
  • Latest
    J:223398 Kaempf N, et al., Overlapping functions of stonin 2 and SV2 in sorting of the calcium sensor synaptotagmin 1 to synaptic vesicles. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7297-302

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory