About   Help   FAQ
Sv2b
Gene Detail
 Symbol
Name
ID
Sv2b
synaptic vesicle glycoprotein 2 b
MGI:1927338
Synonyms A830038F04Rik, mKIAA0735
Feature Type protein coding gene
Genetic Map
Chromosome 7
43.62 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:75114897-75309262 bp, - strand
From Ensembl annotation of GRCm38

  194366 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32236  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

Protein SuperFamily: synaptic vesicle protein SV2
Gene Tree: Sv2b

Human
homologs
Human Homolog SV2B, synaptic vesicle glycoprotein 2B
NCBI Gene ID 9899
neXtProt AC  NX_Q7L1I2
Human Synonyms  HsT19680
Human Chr (Location)  15q26.1; chr15:91099773-91301309 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation are phenotypically normal, and Sv2a/Sv2b double knockouts are no more affected than Sv2a single knockouts.
 
Interactions
Sv2b interacts with 344 markers (Mir1b, Mir7-1, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process neurotransmitter transport, synaptic transmission, ...
Component cell junction, cytoplasmic vesicle, ...
Function transmembrane transporter activity, transporter activity
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (394)    Tissues (157)    Images (57)
Theiler Stages: 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 9
RNA in situ 378
Western blot 7
cDNA source data(35)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) cDNA(36)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000053025 (Evidence)
Entrez Gene64176 (Evidence)
UniGene273082
DFCITC1580517, TC1603349, TC1633352
DoTSDT.101736645, DT.101736646, DT.55154341, DT.55281227, DT.94166889, DT.99852217
NIA Mouse Gene IndexU080092
Consensus CDS ProjectCCDS21368.1
International Mouse Knockout Project StatusSv2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053025 Ensembl Gene Model | MGI Sequence Detail 194366 C57BL/6J ±  kb
transcript ENSMUST00000165175 Ensembl | MGI Sequence Detail 5521 Not Applicable 
polypeptide ENSMUSP00000127245 Ensembl | MGI Sequence Detail 683 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(12) UniProt(2)
Polymorphisms SNPs within 2kb(1764 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 General substrate transporter
InterPro IPR011701 Major facilitator superfamily
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
InterPro IPR001646 Pentapeptide repeat
InterPro IPR005829 Sugar transporter, conserved site
InterPro IPR022308 Synaptic vesicle protein SV2
Protein Ontology PR:000015850 synaptic vesicle glycoprotein 2B
References (Earliest) J:33098 Gautam M, et al., Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell. 1996 May 17;85(4):525-35
(Latest) J:204383 Yao J, et al., Loss of the SV2-like protein SVOP produces no apparent deficits in laboratory mice. PLoS One. 2013;8(7):e68215
All references(65)
Other
accession IDs
MGI:2142055, MGI:2443605

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/16/2014
MGI 5.19
The Jackson Laboratory