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Sv2b
Gene Detail
Symbol

Name
ID
Sv2b
synaptic vesicle glycoprotein 2 b
MGI:1927338
Synonyms
A830038F04Rik, mKIAA0735
Feature Type
protein coding gene
Genetic Map
Chromosome 7
43.62 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:75114897-75309262 bp, - strand
From Ensembl annotation of GRCm38

  194366 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32236  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

HCOP human homology predictions: SV2B
Protein SuperFamily: synaptic vesicle protein SV2
Gene Tree: Sv2b

Human
homologs
SV2B, synaptic vesicle glycoprotein 2B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9899
neXtProt AC: NX_Q7L1I2

Human Synonyms: HsT19680

Human Chr (Location): 15q26.1; chr15:91099721-91301309 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation are phenotypically normal, and Sv2a/Sv2b double knockouts are no more affected than Sv2a single knockouts.
 
Interactions
Sv2b interacts with 344 markers (Mir1b, Mir7-1, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process neurotransmitter transport, synaptic transmission, ...
Component cell junction, cytoplasmic vesicle, ...
Function transmembrane transporter activity, transporter activity
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (394)    Tissues (157)    Images (57)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 378
Western blot 7
cDNA source data(35)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase sv2b    NEW 
Molecular
reagents
All nucleic(36) cDNA(36)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000053025 (Evidence)
Entrez Gene 64176 (Evidence)
UniGene 273082
DFCI TC1633352, TC1603349, TC1580517
DoTS DT.101736646, DT.101736645, DT.55154341, DT.94166889, DT.55281227, DT.99852217
NIA Mouse Gene Index U080092
Consensus CDS Project CCDS21368.1
International Mouse Phenotyping Consortium Status Sv2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053025 Ensembl Gene Model | MGI Sequence Detail 194366 C57BL/6J ±  kb
transcript ENSMUST00000165175 Ensembl | MGI Sequence Detail 5521 Not Applicable 
polypeptide ENSMUSP00000127245 Ensembl | MGI Sequence Detail 683 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(12) UniProt(2)
Polymorphisms
SNPs within 2kb(1764 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 General substrate transporter
InterPro IPR011701 Major facilitator superfamily
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR001646 Pentapeptide repeat
InterPro IPR005829 Sugar transporter, conserved site
InterPro IPR022308 Synaptic vesicle protein SV2
Protein Ontology PR:000015850 synaptic vesicle glycoprotein 2B
References
(Earliest) J:33098 Gautam M, et al., Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell. 1996 May 17;85(4):525-35
(Latest) J:217012 Detrait E, et al., Lack of synaptic vesicle protein SV2B protects against amyloid-beta(2)(5)(-)(3)(5)-induced oxidative stress, cholinergic deficit and cognitive impairment in mice. Behav Brain Res. 2014 Sep 1;271:277-85
All references(66)
Other
accession IDs
MGI:2142055, MGI:2443605

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory