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Zbtb33
Gene Detail
 Symbol
Name
ID
Zbtb33
zinc finger and BTB domain containing 33
MGI:1927290
Synonyms E130014G12Rik, kaiso, ZNF-Kaiso
Feature Type protein coding gene
Genetic Map
Chromosome X
22.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:38189812-38194684 bp, + strand
From VEGA annotation of GRCm38

  4873 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4931  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Zbtb33

Human
homologs
Human Homolog ZBTB33, zinc finger and BTB domain containing 33
NCBI Gene ID 10009
neXtProt AC  NX_Q86T24
Human Synonyms  ZNF348, ZNF-kaiso
Human Chr (Location)  Xq23; chrX:120250752-120258396 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
 
Homozygous null females and hemizygous null males are viable, fertile and overtly normal with no detectable changes in blood cell composition.
 
Interactions
Zbtb33 interacts with 338 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process negative regulation of transcription, DNA-templated, regulation of transcription, DNA-templated, ...
Component cytoplasm, nucleus, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (221)    Tissues (221)    Images (8)
Theiler Stages: 2, 3, 4, 5, 15, 17, 21, 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 213
RT-PCR 8
cDNA source data(51)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(54) cDNA(52) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017200 (Evidence)
Ensembl Gene ModelENSMUSG00000048047 (Evidence)
Entrez Gene56805 (Evidence)
UniGene391248
NIA Mouse Gene IndexU019797
Consensus CDS ProjectCCDS30088.1
International Mouse Knockout Project StatusZbtb33
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017200 VEGA Gene Model | MGI Sequence Detail 4873 C57BL/6J ±  kb
transcript OTTMUST00000041655 VEGA | MGI Sequence Detail 2567 Not Applicable 
polypeptide OTTMUSP00000018710 VEGA | MGI Sequence Detail 671 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017575 transcriptional regulator Kaiso
References (Earliest) J:54621 Daniel JM, et al., The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol Cell Biol. 1999 May;19(5):3614-23
(Latest) J:211837 Koh DI, et al., Kaiso is a key regulator of spleen germinal center formation by repressing Bcl6 expression in splenocytes. Biochem Biophys Res Commun. 2013 Dec 13;442(3-4):177-82
All references(42)
Other
accession IDs
MGI:2148006, MGI:2444590

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory