About   Help   FAQ
Zbtb33 Gene Detail
Summary
  • Symbol
    Zbtb33
  • Name
    zinc finger and BTB domain containing 33
  • Synonyms
    E130014G12Rik, kaiso, ZNF-Kaiso
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927290
    NCBI Gene: 56805
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:37278670-37285923 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 22.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    163 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927290
 protein coding gene ChrX:37278670-37285923 (+)
129S1/SvImJ ENSMUSG00200021937
 protein coding gene ChrX:21210192-21217446 (+)
A/J ENSMUSG00195025032
 protein coding gene ChrX:23900777-23908032 (+)
AKR/J ENSMUSG00220024467
 protein coding gene ChrX:20898937-20906191 (+)
BALB/cJ ENSMUSG00180011681
 protein coding gene ChrX:21647460-21654716 (+)
C3H/HeJ ENSMUSG00175022579
 protein coding gene ChrX:24640631-24647885 (+)
C57BL/6NJ ENSMUSG00215020449
 protein coding gene ChrX:21610462-21617715 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033013
 protein coding gene ChrX:31546266-31553494 (+)
CAST/EiJ ENSTCUG00005032993
 protein coding gene ChrX:23759498-23766743 (+)
CBA/J ENSMUSG00210032936
 protein coding gene ChrX:21954804-21962059 (+)
DBA/2J ENSMUSG00185023956
 protein coding gene ChrX:32635341-32642595 (+)
FVB/NJ ENSMUSG00205007143
 protein coding gene ChrX:20587157-20594412 (+)
JF1/MsJ ENSUMUG00000025635
 protein coding gene ChrX:51679884-51687129 (+)
LP/J ENSMUSG00230011392
 protein coding gene ChrX:39127816-39135070 (+)
NOD/ShiLtJ ENSMUSG00190021612
 protein coding gene ChrX:21075821-21083075 (+)
NZO/HlLtJ ENSMUSG00225039337
 protein coding gene ChrX:44334330-44341584 (+)
PWK/PhJ ENSLUMG00010036847
 protein coding gene ChrX:21408530-21415773 (+)
SPRET/EiJ ENSMSPG00010017314
 protein coding gene ChrX:22787572-22794785 (+)
WSB/EiJ ENSIUOG00005037954
 protein coding gene ChrX:22102437-22109680 (+)



Homology
more
  • Human Ortholog
    ZBTB33, zinc finger and BTB domain containing 33
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZBTB33, zinc finger and BTB domain containing 33
  • Synonyms
    ZNF348, ZNF-kaiso
  • Links
    NCBI Gene ID: 10009
    UniProt: Q86T24

  • Chr Location
    Xq24; chrX:120250752-120259741 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    13 phenotype references
Homozygous null females and hemizygous null males are viable, fertile and overtly normal with no detectable changes in blood cell composition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    835
  • Tissues
    233
  • cDNA Data
    52
  • Literature Summary
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 56805 NCBI Gene Model | MGI Sequence Detail 7254 C57BL/6J ±  kb
transcript NM_020256 RefSeq | MGI Sequence Detail 5122 C57BL/6  
polypeptide Q8BN78 UniProt | EBI | MGI Sequence Detail 671 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 57
    cDNA 53
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
less
MGI:2148006, MGI:2444590
References
more
  • Summaries
    All 62
    Developmental Gene Expression 11
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:54621 Daniel JM, et al., The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol Cell Biol. 1999 May;19(5):3614-23
  • Latest
    J:391178 Lessey LR, et al., Overexpression of the POZ-ZF protein Kaiso promotes intestinal tumorigenesis in murine models. Biochem Biophys Res Commun. 2026 Aug 5;832:154393
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory