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Ralb Gene Detail
Summary
  • Symbol
    Ralb
  • Name
    v-ral simian leukemia viral oncogene B
  • Synonyms
    5730472O18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927244
    NCBI Gene: 64143
  • Gene Overview
    MyGene.info: RALB
Location & Maps
more
  • Sequence Map
    Chr1:119470305-119504794 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34490 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 52.29 cM, cytoband E2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RALB, RAS like proto-oncogene B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RALB, RAS like proto-oncogene B
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 5899
    neXtProt AC: NX_P11234

  • Chr Location
    2q14.2; chr2:120240070-120294711 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 3 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    60
  • Chemically induced (other)
    2
  • Gene trapped
    52
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    3 involving Ralb
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit no obvious abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021776 VEGA Gene Model | MGI Sequence Detail 34490 C57BL/6J ±  kb
transcript OTTMUST00000051693 VEGA | MGI Sequence Detail 2289 Not Applicable  
polypeptide OTTMUSP00000024377 VEGA | MGI Sequence Detail 206 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    213 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013696 ras-related protein Ral-B
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR028412 Ras-related protein Ral
    IPR001806 Small GTPase superfamily
    IPR020849 Small GTPase superfamily, Ras type
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
less
  • All nucleic 85
    cDNA 85

    Microarray probesets 4
Other
Accession IDs
less
MGI:1917847
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:65398 Zhao Z, et al., Tissue-specific expression of GTPas RalA and RalB during embryogenesis and regulation by epithelial-mesenchymal interaction. Mech Dev. 2000 Oct;97(1-2):201-4
  • Latest
    J:199742 Peschard P, et al., Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis. Curr Biol. 2012 Nov 6;22(21):2063-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory