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Rala
Gene Detail
Symbol

Name
ID
Rala
v-ral simian leukemia viral oncogene homolog A (ras related)
MGI:1927243
Synonyms
3010001O15Rik, Ral, Rasl1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
6.05 cM, cytoband A3.1
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr13:17880575-17944239 bp, - strand
From VEGA annotation of GRCm38

  63665 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3942  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RALA
Protein SuperFamily: ras protein
Gene Tree: Rala

Human
homologs
RALA, v-ral simian leukemia viral oncogene homolog A (ras related)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5898
neXtProt AC: NX_P11233

Human Synonyms: RAL

Human Chr (Location): 7p15-p13; chr7:39622955-39708124 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(31) Radiation induced(1) Targeted(6)
Genomic Mutations involving Rala (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit complete preweaning lethality and exencephaly.
 
Interactions
Rala interacts with 311 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process actin cytoskeleton reorganization, cell cycle, ...
Component cell surface, cleavage furrow, ...
Function ATPase binding, Edg-2 lysophosphatidic acid receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (120)    Tissues (81)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 120
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rala ; ZFIN ralaa    NEW 
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000017001 (Evidence)
Ensembl Gene Model ENSMUSG00000008859 (Evidence)
Entrez Gene 56044 (Evidence)
DFCI TC1575810
DoTS DT.110967690, DT.491148
NIA Mouse Gene Index U034533
Consensus CDS Project CCDS26255.1
International Mouse Phenotyping Consortium Status Rala
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017001 VEGA Gene Model | MGI Sequence Detail 63665 C57BL/6J ±  kb
transcript OTTMUST00000041223 VEGA | MGI Sequence Detail 2684 Not Applicable 
polypeptide OTTMUSP00000018472 VEGA | MGI Sequence Detail 206 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(4) : SNPs within 2kb(285 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR028412 Ras-related protein Ral
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013695 ras-related protein Ral-A
References
(Earliest) J:10344 Justice MJ, et al., A molecular genetic linkage map of mouse chromosome 13 anchored by the beige (bg) and satin (sa) loci. Genomics. 1990 Feb;6(2):341-51
(Latest) J:199742 Peschard P, et al., Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis. Curr Biol. 2012 Nov 6;22(21):2063-8
All references(55)
Other
accession IDs
MGD-MRK-13757, MGD-MRK-13771, MGI:1917666, MGI:2145427, MGI:97861

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory