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Rala Gene Detail
Summary
  • Symbol
    Rala
  • Name
    v-ral simian leukemia viral oncogene A (ras related)
  • Synonyms
    3010001O15Rik, Ral, Rasl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927243
    NCBI Gene: 56044
  • Gene Overview
    MyGene.info: RALA
Location & Maps
more
  • Sequence Map
    Chr13:17880575-17944239 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63665 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 6.05 cM, cytoband A3.1
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    RALA, RAS like proto-oncogene A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RALA, RAS like proto-oncogene A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RAL
  • Links
    NCBI Gene ID: 5898
    neXtProt AC: NX_P11233

  • Chr Location
    7p15-p13; chr7:39622955-39708124 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 4 alleles in 4 genetic backgrounds
    10 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    38
  • Gene trapped
    31
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Rala
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit complete preweaning lethality and exencephaly.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017001 VEGA Gene Model | MGI Sequence Detail 63665 C57BL/6J ±  kb
transcript OTTMUST00000041223 VEGA | MGI Sequence Detail 2684 Not Applicable  
polypeptide OTTMUSP00000018472 VEGA | MGI Sequence Detail 206 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    282 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013695 ras-related protein Ral-A
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR028412 Ras-related protein Ral
    IPR001806 Small GTPase superfamily
    IPR020849 Small GTPase superfamily, Ras type
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
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  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-13757, MGD-MRK-13771, MGI:1917666, MGI:2145427, MGI:97861
References
more
  • Summaries
    All 54
    Developmental Gene Expression 3
    Gene Ontology 11
    Phenotypes 14
  • Earliest
    J:10344 Justice MJ, et al., A molecular genetic linkage map of mouse chromosome 13 anchored by the beige (bg) and satin (sa) loci. Genomics. 1990 Feb;6(2):341-51
  • Latest
    J:199742 Peschard P, et al., Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis. Curr Biol. 2012 Nov 6;22(21):2063-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory