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Mllt1
Gene Detail
 Symbol
Name
ID
Mllt1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MGI:1927238
Synonyms BAM11, ENL, LTG19
Feature Type protein coding gene
Genetic Map
Chromosome 17
29.56 cM, cytoband E1.1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:56892612-56935388 bp, - strand
From Ensembl annotation of GRCm38

  42777 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4339  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: MLLT
Gene Tree: Mllt1

Human
homologs
Human Homolog MLLT1, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
NCBI Gene ID 4298
neXtProt AC  NX_Q03111
Human Synonyms  ENL, LTG19, YEATS1
Human Chr (Location)  19p13.3; chr19:6210381-6279948 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(10) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a knock-out allele die prior to E8.5.
 
Interactions
Mllt1 interacts with 197 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process negative regulation of protein kinase activity
Component cytoplasm, nucleus
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (40)    Tissues (36)    Images (7)
Theiler Stages: 15, 17, 19, 24, 26
Assay TypeResults
RNA in situ 40
cDNA source data(82)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(83) Genomic(1) cDNA(82)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000024212 (Evidence)
Entrez Gene64144 (Evidence)
UniGene148748
DFCITC1575282
DoTSDT.94177830
NIA Mouse Gene IndexU037961
Consensus CDS ProjectCCDS28918.1
International Mouse Knockout Project StatusMllt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024212 Ensembl Gene Model | MGI Sequence Detail 42777 C57BL/6J ±  kb
transcript ENSMUST00000025053 Ensembl | MGI Sequence Detail 3608 Not Applicable 
polypeptide ENSMUSP00000025053 Ensembl | MGI Sequence Detail 547 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(170 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005033 YEATS
Protein Ontology PR:000010449 protein ENL
References (Earliest) J:65127 Kikuchi Y, et al., Identification and characterization of a molecule, BAM11, that associates with the pleckstrin homology domain of mouse Btk. Int Immunol. 2000 Oct;12(10):1397-408
(Latest) J:196071 van der Weyden L, et al., Cancer of mice and men: old twists and new tails. J Pathol. 2013 May;230(1):4-16
All references(33)
Other
accession IDs
MGI:2146746

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory