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Mllt1
Gene Detail
Symbol

Name
ID
Mllt1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MGI:1927238
Synonyms
BAM11, ENL, LTG19
Feature Type
protein coding gene
Genetic Map
Chromosome 17
29.56 cM, cytoband E1.1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:56892612-56935388 bp, - strand
From Ensembl annotation of GRCm38

  42777 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4339  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: MLLT1
Protein SuperFamily: MLLT
Gene Tree: Mllt1

Human
homologs
MLLT1, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4298
neXtProt AC: NX_Q03111

Human Synonyms: ENL, LTG19, YEATS1

Human Chr (Location): 19p13.3; chr19:6210381-6279948 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(10) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Embryos homozygous for a knock-out allele die prior to E8.5.
 
Interactions
Mllt1 interacts with 196 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process negative regulation of protein kinase activity
Component cytoplasm, nucleolus, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (40)    Tissues (36)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 40
cDNA source data(82)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mllt1    NEW 
Molecular
reagents
All nucleic(83) Genomic(1) cDNA(82)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000024212 (Evidence)
Entrez Gene 64144 (Evidence)
UniGene 148748
DFCI TC1575282
DoTS DT.94177830
NIA Mouse Gene Index U037961
Consensus CDS Project CCDS28918.1
International Mouse Phenotyping Consortium Status Mllt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024212 Ensembl Gene Model | MGI Sequence Detail 42777 C57BL/6J ±  kb
transcript ENSMUST00000025053 Ensembl | MGI Sequence Detail 3608 Not Applicable 
polypeptide ENSMUSP00000025053 Ensembl | MGI Sequence Detail 547 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(170 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005033 YEATS
Protein Ontology PR:000010449 protein ENL
References
(Earliest) J:65127 Kikuchi Y, et al., Identification and characterization of a molecule, BAM11, that associates with the pleckstrin homology domain of mouse Btk. Int Immunol. 2000 Oct;12(10):1397-408
(Latest) J:196071 van der Weyden L, et al., Cancer of mice and men: old twists and new tails. J Pathol. 2013 May;230(1):4-16
All references(32)
Other
accession IDs
MGI:2146746

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory