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Suclg1
Gene Detail
Symbol

Name
ID
Suclg1
succinate-CoA ligase, GDP-forming, alpha subunit
MGI:1927234
Synonyms
1500000I01Rik, Sucla1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
32.40 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:73248382-73276911 bp, + strand
From VEGA annotation of GRCm38

  28530 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55785  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SUCLG1
Protein SuperFamily: succinyl-CoA synthetase, alpha subunit
Gene Tree: Suclg1

Human
homologs
SUCLG1, succinate-CoA ligase, alpha subunit
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8802
neXtProt AC: NX_P53597

Human Synonyms: GALPHA, MTDPS9, SUCLA1

Human Chr (Location): 2p11.2; chr2:84423523-84459462 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SUCLG1

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(7) Spontaneous(1) Targeted(2)
Genomic Mutations involving Suclg1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Suclg1 interacts with 117 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process metabolic process, nucleoside triphosphate biosynthetic process, ...
Component cytoplasm, extracellular exosome, ...
Function catalytic activity, cofactor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (132)    Tissues (102)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 132
cDNA source data(202)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase suclg1    NEW 
Molecular
reagents
All nucleic(204) cDNA(203) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023469 (Evidence)
Ensembl Gene Model ENSMUSG00000052738 (Evidence)
Entrez Gene 56451 (Evidence)
UniGene 29845
DFCI TC1573475, TC1678781
DoTS DT.101170159, DT.101222331, DT.534397
NIA Mouse Gene Index U007049
EC 6.2.1.4, 6.2.1.5
Consensus CDS Project CCDS20246.2
International Mouse Phenotyping Consortium Status Suclg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023469 VEGA Gene Model | MGI Sequence Detail 28530 C57BL/6J ±  kb
transcript OTTMUST00000057082 VEGA | MGI Sequence Detail 1519 Not Applicable 
polypeptide OTTMUSP00000027499 VEGA | MGI Sequence Detail 346 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(187 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005811 ATP-citrate lyase/succinyl-CoA ligase
InterPro IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site
InterPro IPR003781 CoA-binding
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR005810 Succinyl-CoA ligase, alpha subunit
InterPro IPR016102 Succinyl-CoA synthetase-like
Protein Ontology PR:000015812 succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
References
(Earliest) J:50333 Johnson JD, et al., Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. J Biol Chem. 1998 Oct 16;273(42):27580-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)
Other
accession IDs
MGI:1915249

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory