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Trio Gene Detail
Summary
  • Symbol
    Trio
  • Name
    triple functional domain (PTPRF interacting)
  • Synonyms
    6720464I07Rik, Solo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927230
    NCBI Gene: 223435
  • Gene Overview
    MyGene.info: TRIO
Location & Maps
more
  • Sequence Map
    Chr15:27730652-28025848 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      295197 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 10.40 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TRIO, trio Rho guanine nucleotide exchange factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRIO, trio Rho guanine nucleotide exchange factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARHGEF23, tgat
  • Links
    NCBI Gene ID: 7204
    neXtProt AC: NX_O75962

  • Chr Location
    5p15.2; chr5:14143708-14510204 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 20847
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TRIO
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 2 alleles in 3 genetic backgrounds
    6 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    2
  • Gene trapped
    5
  • Targeted
    6
  • Genomic Mutations
    2 involving Trio
  • Incidental Mutations
Homozygous mutant mice die during late embryonic development or shortly after birth. They exhibit abnormal skeletal myogenesis and display aberrant organization within the hippocampus and olfactory bulb.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022263 Ensembl Gene Model | MGI Sequence Detail 295197 C57BL/6J ±  kb
transcript ENSMUST00000090247 Ensembl | MGI Sequence Detail 11494 Not Applicable  
polypeptide ENSMUSP00000087714 Ensembl | MGI Sequence Detail 3103 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2039 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:1924980, MGI:2145897
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 18
  • Earliest
    J:65380 O'Brien SP, et al., Skeletal muscle deformity and neuronal disorder in trio exchange factor-deficient mouse embryos. Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12074-8
  • Latest
    J:229257 Gu Z, et al., Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory