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Pard6a Gene Detail
Summary
  • Symbol
    Pard6a
  • Name
    par-6 family cell polarity regulator alpha
  • Synonyms
    0710008C04Rik, 2610010A15Rik, Par6, Par-6, PAR6alpha, Par6c, TAX40, Tip-40
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927223
    NCBI Gene: 56513
  • Gene Overview
    MyGene.info: PARD6A
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:105701148-105703494 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.04 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927223
protein coding gene Chr8:105701148-105703496 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034055
protein coding gene Chr8:108003919-108006797 (+)
A/J MGP_AJ_G0034036
protein coding gene Chr8:103687528-103689867 (+)
AKR/J MGP_AKRJ_G0033962
protein coding gene Chr8:106688331-106690670 (+)
BALB/cJ MGP_BALBcJ_G0034029
protein coding gene Chr8:103877890-103880229 (+)
C3H/HeJ MGP_C3HHeJ_G0033741
protein coding gene Chr8:107429108-107431447 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034549
protein coding gene Chr8:111971862-111974201 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031491
protein coding gene Chr8:96825541-96827905 (+)
CAST/EiJ MGP_CASTEiJ_G0033067
protein coding gene Chr8:106928982-106931322 (+)
CBA/J MGP_CBAJ_G0033714
protein coding gene Chr8:115565332-115567671 (+)
DBA/2J MGP_DBA2J_G0033869
protein coding gene Chr8:103035080-103037419 (+)
FVB/NJ MGP_FVBNJ_G0033815
protein coding gene Chr8:101963549-101965888 (+)
LP/J MGP_LPJ_G0033960
protein coding gene Chr8:108211127-108213466 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033858
protein coding gene Chr8:118762748-118765134 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034567
protein coding gene Chr8:106652280-106654619 (+)
PWK/PhJ MGP_PWKPhJ_G0032768
protein coding gene Chr8:102425361-102427804 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032609
protein coding gene Chr8:105337384-105339730 (+)
WSB/EiJ MGP_WSBEiJ_G0033183
protein coding gene Chr8:107321920-107324260 (+)



Homology
more
  • Human Ortholog
    PARD6A, par-6 family cell polarity regulator alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PARD6A, par-6 family cell polarity regulator alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PAR6, PAR-6A, PAR6alpha, PAR6C, TAX40, TIP-40
  • Links
    NCBI Gene ID: 50855
    neXtProt AC: NX_Q9NPB6
    UniProt: Q9NPB6

  • Chr Location
    16q22.1; chr16:67660948-67662778 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56513 NCBI Gene Model | MGI Sequence Detail 2347 C57BL/6J ±  kb
    transcript NM_001047436 RefSeq | MGI Sequence Detail 1297 C57BL/6  
    polypeptide Q9Z101 UniProt | EBI | MGI Sequence Detail 346 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 32
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915672, MGI:1925639
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 20
      Gene Ontology 11
      Phenotypes 6
    • Earliest
      J:51233 Hung TJ, et al., PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos. Development. 1999 Jan;126(1):127-35
    • Latest
      J:234018 Singh S, et al., Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition. Elife. 2016;5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory