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Nt5c3
Gene Detail
 Symbol
Name
ID
Nt5c3
5'-nucleotidase, cytosolic III
MGI:1927186
Synonyms 1600024P05Rik, 2610206B05Rik, 3110004A18Rik, cN-III, lupin, p36, PN-1, PN-I, PSN1, Umph1, Umph-1
Feature Type protein coding gene
Genetic Map
Chromosome 6
27.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:56882400-56923932 bp, - strand
From VEGA annotation of GRCm38

  41533 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9534  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nt5c3

Human
homologs
Human Homolog NT5C3A, 5'-nucleotidase, cytosolic IIIA
NCBI Gene ID 51251
neXtProt AC  NX_Q9H0P0
Human Synonyms  cN-III, hUMP1, NT5C3, p36, P5'N-1, P5N-1, PN-I, POMP, PSN1, UMPH, UMPH1
Human Chr (Location)  7p14.3; chr7:33014113-33062797 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NT5C3A
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Nt5c3 interacts with 104 markers (Mir7-1, Mir17, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process adenosine metabolic process, dephosphorylation, ...
Component cytoplasm, endoplasmic reticulum, ...
Function 5'-nucleotidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (217)    Tissues (147)    Images (33)
Theiler Stages: 10, 15, 17, 18, 20, 21, 22, 23, 24, 25, 27, 28
Assay TypeResults
Immunohistochemistry 21
RNA in situ 183
Northern blot 13
cDNA source data(63)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(65) cDNA(65)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023209 (Evidence)
Ensembl Gene ModelENSMUSG00000029780 (Evidence)
Entrez Gene107569 (Evidence)
UniGene158936
DFCITC1576574, TC1599633, TC1611276, TC1678758, TC1736781, TC1752564
DoTSDT.101184537, DT.534169, DT.94156526, DT.97337829, DT.99860286
NIA Mouse Gene IndexU027357
EC3.1.3.5
PDB2BDU, 2G0A, 2Q4T, 2G06, 2G07, 2G08, 2G09, 4FE3, 4KX3, 4KX5
Consensus CDS ProjectCCDS20171.1, CCDS57424.1
International Mouse Knockout Project StatusNt5c3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023209 VEGA Gene Model | MGI Sequence Detail 41533 C57BL/6J ±  kb
transcript OTTMUST00000056164 VEGA | MGI Sequence Detail 1676 Not Applicable 
polypeptide OTTMUSP00000026957 VEGA | MGI Sequence Detail 331 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(14) UniProt(2)
Polymorphisms SNPs within 2kb(306 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023214 HAD-like domain
InterPro IPR006383 HAD-superfamily hydrolase, subfamily IB, PSPase-like
InterPro IPR006434 Pyrimidine 5'-nucleotidase, eukaryotic
Protein Ontology PR:000011455 cytosolic 5'-nucleotidase 3
References (Earliest) J:7039 Swallow DM, et al., Isozymes of rodent 5'-nucleotidase: evidence for two independent structural loci Umph-1 and Umph-2. Ann Hum Genet. 1983 Jan;47 Pt 1:9-17
(Latest) J:199745 Grobosky CL, et al., Structural basis of substrate specificity and selectivity of murine cytosolic 5'-nucleotidase III. J Mol Biol. 2012 Nov 2;423(4):540-54
All references(39)
Other
accession IDs
MGD-MRK-15350, MGD-MRK-15352, MGI:1914406, MGI:1920319, MGI:1923756, MGI:2141488, MGI:98902

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory