Nt5c3
Gene Detail

Symbol Name ID

Nt5c3 5'-nucleotidase, cytosolic III MGI:1927186

Synonyms

1600024P05Rik, 2610206B05Rik, 3110004A18Rik, cN-III, lupin, p36, PN-1, PN-I, PSN1, Umph1, Umph-1

Feature Type

protein coding gene

Genetic Map

Chromosome 6

27.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:56882400-56923932 bp, - strand From VEGA annotation of GRCm38   41533 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9534  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nt5c3

Human homologs

Human Homolog		NT5C3A, 5'-nucleotidase, cytosolic IIIA
NCBI Gene ID		51251
neXtProt AC		NX_Q9H0P0
Human Synonyms		cN-III, hUMP1, NT5C3, p36, P5'N-1, P5N-1, PN-I, POMP, PSN1, UMPH, UMPH1
Human Chr (Location)		7p14.3; chr7:33053725-33102409 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NT5C3A

Alleles and phenotypes

All alleles(6) : Targeted(2) Gene trapped(4)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	adenosine metabolic process, dephosphorylation, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	5'-nucleotidase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (217)    Tissues (147)    Images (33)
Theiler Stages: 10, 15, 17, 18, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	21
RNA in situ	183
Northern blot	13

cDNA source data(67)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(69) cDNA(69)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000023209 (Evidence)
Ensembl Gene Model	ENSMUSG00000029780 (Evidence)
Entrez Gene	107569 (Evidence)
UniGene	158936
DFCI	TC1576574, TC1599633, TC1611276, TC1678758, TC1736781, TC1752564
DoTS	DT.101184537, DT.534169, DT.94156526, DT.97337829, DT.99860286
NIA Mouse Gene Index	U027357
EC	3.1.3.5
PDB	2BDU, 2G0A, 2Q4T, 2G06, 2G07, 2G08, 2G09, 4FE3
Consensus CDS Project	CCDS20171.1, CCDS57424.1
International Mouse Knockout Project Status	Nt5c3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023209	VEGA Gene Model | MGI Sequence Detail	41533	C57BL/6J
transcript	OTTMUST00000056164	VEGA | MGI Sequence Detail	1676	Not Applicable
polypeptide	OTTMUSP00000026957	VEGA | MGI Sequence Detail	331	Not Applicable

All sequences(56) RefSeq(4) UniProt(1)

Polymorphisms

SNPs(260 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023214	HAD-like domain
InterPro	IPR006383	HAD-superfamily hydrolase, subfamily IB, PSPase-like
InterPro	IPR006434	Pyrimidine 5'-nucleotidase, eukaryotic
Protein Ontology	PR:000011455	cytosolic 5'-nucleotidase 3

References

(Earliest) J:7039 Swallow DM, et al., Isozymes of rodent 5'-nucleotidase: evidence for two independent structural loci Umph-1 and Umph-2. Ann Hum Genet. 1983 Jan;47 Pt 1:9-17
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(38)

Other accession IDs

MGD-MRK-15350, MGD-MRK-15352, MGI:1914406, MGI:1920319, MGI:1923756, MGI:2141488, MGI:98902