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Git1 Gene Detail
Summary
  • Symbol
    Git1
  • Name
    GIT ArfGAP 1
  • Synonyms
    Cat-1, p95Cat
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927140
    NCBI Gene: 216963
  • Gene Overview
    MyGene.info: GIT1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:77493562-77507786 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.61 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    28 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927140
protein coding gene Chr11:77493412-77507786 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018748
protein coding gene Chr11:78400278-78416702 (+)
A/J MGP_AJ_G0018714
protein coding gene Chr11:75439276-75453969 (+)
AKR/J MGP_AKRJ_G0018684
protein coding gene Chr11:77727931-77742541 (+)
BALB/cJ MGP_BALBcJ_G0018688
protein coding gene Chr11:75823882-75838704 (+)
C3H/HeJ MGP_C3HHeJ_G0018501
protein coding gene Chr11:77752849-77767020 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019139
protein coding gene Chr11:80859646-80877776 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016774
protein coding gene Chr11:72421816-72435617 (+)
CAST/EiJ MGP_CASTEiJ_G0018055
protein coding gene Chr11:78147014-78163467 (+)
CBA/J MGP_CBAJ_G0018471
protein coding gene Chr11:84371765-84393602 (+)
DBA/2J MGP_DBA2J_G0018580
protein coding gene Chr11:75025517-75039687 (+)
FVB/NJ MGP_FVBNJ_G0018570
protein coding gene Chr11:74596994-74609726 (+)
LP/J MGP_LPJ_G0018651
protein coding gene Chr11:78962860-78977068 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018596
protein coding gene Chr11:84833161-84847302 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019179
protein coding gene Chr11:77939049-77953209 (+)
PWK/PhJ MGP_PWKPhJ_G0017826
protein coding gene Chr11:75782685-75797405 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017617
protein coding gene Chr11:77551705-77566726 (+)
WSB/EiJ MGP_WSBEiJ_G0018108
protein coding gene Chr11:77757980-77774707 (+)



Homology
more
  • Human Ortholog
    GIT1, GIT ArfGAP 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GIT1, GIT ArfGAP 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 28964
    neXtProt AC: NX_Q9Y2X7
    UniProt: Q9Y2X7

  • Chr Location
    17q11.2; chr17:29573469-29589592 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Git1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 3 alleles in 4 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal lethality associated with abnormal lung vascular development with surviving mice exhibiting abnormal learning and anxiety related behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000011877 Ensembl Gene Model | MGI Sequence Detail 14225 C57BL/6J ±  kb
transcript ENSMUST00000037285 Ensembl | MGI Sequence Detail 3512 Not Applicable  
polypeptide ENSMUSP00000037210 Ensembl | MGI Sequence Detail 770 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 112
    cDNA 112

    Microarray probesets 3
References
more
  • Summaries
    All 58
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 8
    Phenotypes 27
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:259711 Martyn AC, et al., GIT1 regulates synaptic structural plasticity underlying learning. PLoS One. 2018;13(3):e0194350

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory