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Git1 Gene Detail
Summary
  • Symbol
    Git1
  • Name
    G protein-coupled receptor kinase-interactor 1
  • Synonyms
    Cat-1, p95Cat
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927140
    NCBI Gene: 216963
  • Gene Overview
    MyGene.info: GIT1
Location & Maps
more
  • Sequence Map
    Chr11:77493562-77507786 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14225 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.61 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    GIT1, GIT ArfGAP 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GIT1, GIT ArfGAP 1
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 28964
    neXtProt AC: NX_Q9Y2X7

  • Chr Location
    17p11.2; chr17:29573469-29589592 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Git1 mouse models

Human Disease Mouse Models
       Attention Deficit-Hyperactivity Disorder; ADHD   OMIM: 143465 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 3 alleles in 4 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    28
  • Chemically induced (other)
    1
  • Gene trapped
    22
  • Targeted
    5
  • Genomic Mutations
    2 involving Git1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit postnatal lethality associated with abnormal lung vascular development with surviving mice exhibiting abnormal learning and anxiety related behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008178 VEGA Gene Model | MGI Sequence Detail 14225 C57BL/6J ±  kb
transcript OTTMUST00000018574 VEGA | MGI Sequence Detail 3512 Not Applicable  
polypeptide OTTMUSP00000008532 VEGA | MGI Sequence Detail 770 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    28 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007989 ARF GTPase-activating protein GIT1
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
    IPR001164 Arf GTPase activating protein
    IPR032352 Arf GTPase-activating protein GIT1/2, coiled-coil domain
    IPR022018 ARF GTPase-activating protein GIT1, C-terminal
    IPR013724 GIT, Spa2 homology (SHD) domain
Molecular
Reagents
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  • All nucleic 111
    cDNA 111

    Microarray probesets 3
References
more
  • Summaries
    All 44
    Diseases 2
    Gene Ontology 7
    Phenotypes 24
  • Earliest
    J:56615 Bagrodia S, et al., A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. J Biol Chem. 1999 Aug 6;274(32):22393-400
  • Latest
    J:228729 Montesinos MS, et al., Presynaptic Deletion of GIT Proteins Results in Increased Synaptic Strength at a Mammalian Central Synapse. Neuron. 2015 Dec 2;88(5):918-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory