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Git1
Gene Detail
 Symbol
Name
ID
Git1
G protein-coupled receptor kinase-interactor 1
MGI:1927140
Synonyms Cat-1, p95Cat
Feature Type protein coding gene
Genetic Map
Chromosome 11
46.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:77493562-77507786 bp, + strand
From VEGA annotation of GRCm38

  14225 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32204  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Git1

Human
homologs
Human Homolog GIT1, G protein-coupled receptor kinase interacting ArfGAP 1
NCBI Gene ID 28964
neXtProt AC  NX_Q9Y2X7
Human Chr (Location)  17p11.2; chr17:29573469-29589592 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(22) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit postnatal lethality associated with abnormal lung vascular development with surviving mice exhibiting abnormal learning and anxiety related behavior.
 
Human Diseases Modeled Using Mouse Git1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Git1 interacts with 232 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process positive regulation of GTPase activity, regulation of ARF GTPase activity, ...
Component aggresome, cytoplasm, ...
Function ARF GTPase activator activity, GTPase activator activity, ...
External Resources: FuncBase
Expression
cDNA source data(111)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(111) cDNA(111)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000008178 (Evidence)
Ensembl Gene ModelENSMUSG00000011877 (Evidence)
Entrez Gene216963 (Evidence)
UniGene290182
DFCITC1576102
DoTSDT.101306823, DT.532946
NIA Mouse Gene IndexU012990
Consensus CDS ProjectCCDS25080.1
International Mouse Knockout Project StatusGit1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008178 VEGA Gene Model | MGI Sequence Detail 14225 C57BL/6J ±  kb
transcript OTTMUST00000018574 VEGA | MGI Sequence Detail 3512 Not Applicable 
polypeptide OTTMUSP00000008532 VEGA | MGI Sequence Detail 770 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(28 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR001164 Arf GTPase activating protein
InterPro IPR022018 G protein-coupled receptor kinase-interacting protein 1 C term
InterPro IPR013724 Spa2 homology (SHD) of GIT
Protein Ontology PR:000007989 ARF GTPase-activating protein GIT1
References (Earliest) J:56615 Bagrodia S, et al., A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. J Biol Chem. 1999 Aug 6;274(32):22393-400
(Latest) J:198682 Leo D, et al., Transgenic mouse models for ADHD. Cell Tissue Res. 2013 May 17;
All references(46)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory