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Git1
Gene Detail
Symbol

Name
ID
Git1
G protein-coupled receptor kinase-interactor 1
MGI:1927140
Synonyms
Cat-1, p95Cat
Feature Type
protein coding gene
Genetic Map
Chromosome 11
46.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:77493562-77507786 bp, + strand
From VEGA annotation of GRCm38

  14225 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32204  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: GIT1
Gene Tree: Git1

Human
homologs
GIT1, G protein-coupled receptor kinase interacting ArfGAP 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 28964
neXtProt AC: NX_Q9Y2X7

Human Chr (Location): 17p11.2; chr17:29573469-29589592 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(22) Targeted(5)
Genomic Mutations involving Git1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit postnatal lethality associated with abnormal lung vascular development with surviving mice exhibiting abnormal learning and anxiety related behavior.
 
Human Diseases Modeled in Mice Using Git1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Git1 interacts with 231 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process dendritic spine development, ephrin receptor signaling pathway, ...
Component aggresome, cytoplasm, ...
Function GTPase activator activity, metal ion binding, ...
External Resources: FuncBase
Expression
cDNA source data(111)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100492231 ; ZFIN git1    NEW 
Molecular
reagents
All nucleic(111) cDNA(111)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000008178 (Evidence)
Ensembl Gene Model ENSMUSG00000011877 (Evidence)
Entrez Gene 216963 (Evidence)
UniGene 290182
DFCI TC1576102
DoTS DT.532946, DT.101306823
NIA Mouse Gene Index U012990
Consensus CDS Project CCDS25080.1
International Mouse Phenotyping Consortium Status Git1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008178 VEGA Gene Model | MGI Sequence Detail 14225 C57BL/6J ±  kb
transcript OTTMUST00000018574 VEGA | MGI Sequence Detail 3512 Not Applicable 
polypeptide OTTMUSP00000008532 VEGA | MGI Sequence Detail 770 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(28 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR001164 Arf GTPase activating protein
InterPro IPR022018 G protein-coupled receptor kinase-interacting protein 1 C term
InterPro IPR013724 Spa2 homology (SHD) of GIT
Protein Ontology PR:000007989 ARF GTPase-activating protein GIT1
References
(Earliest) J:56615 Bagrodia S, et al., A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. J Biol Chem. 1999 Aug 6;274(32):22393-400
(Latest) J:213433 Yin G, et al., Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice. PLoS One. 2014;9(2):e89127
All references(45)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory