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Sv2a
Gene Detail
Symbol

Name
ID
Sv2a
synaptic vesicle glycoprotein 2 a
MGI:1927139
Feature Type
protein coding gene
Genetic Map
Chromosome 3
41.65 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:96181151-96195521 bp, + strand
From VEGA annotation of GRCm38

  14371 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32237  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SV2A
Protein SuperFamily: synaptic vesicle protein SV2
Gene Tree: Sv2a

Human
homologs
SV2A, synaptic vesicle glycoprotein 2A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9900
neXtProt AC: NX_Q7L0J3

Human Synonyms: SV2

Human Chr (Location): 1q21.2; chr1:149903318-149917882 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit seizures, retarded growth, and reduced hippocampal (GABA)ergic neurotransmission. Many mutants die shortly after birth, and all are dead by three weeks of age.
 
Interactions
Sv2a interacts with 295 markers (Mir15a, Mir16-1, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cellular calcium ion homeostasis, neurotransmitter transport, ...
Component cell-cell junction, cell junction, ...
Function protein kinase binding, receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (108)    Tissues (101)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 92
Western blot 7
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase sv2a    NEW 
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021899 (Evidence)
Ensembl Gene Model ENSMUSG00000038486 (Evidence)
Entrez Gene 64051 (Evidence)
DFCI TC1574014, TC1660787
DoTS DT.489464
NIA Mouse Gene Index U003591
Consensus CDS Project CCDS17631.1
International Mouse Phenotyping Consortium Status Sv2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021899 VEGA Gene Model | MGI Sequence Detail 14371 C57BL/6J ±  kb
transcript OTTMUST00000052009 VEGA | MGI Sequence Detail 4334 Not Applicable 
polypeptide OTTMUSP00000024563 VEGA | MGI Sequence Detail 742 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(33 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 General substrate transporter
InterPro IPR011701 Major facilitator superfamily
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR001646 Pentapeptide repeat
InterPro IPR005829 Sugar transporter, conserved site
InterPro IPR022308 Synaptic vesicle protein SV2
Protein Ontology PR:000015849 synaptic vesicle glycoprotein 2A
References
(Earliest) J:33098 Gautam M, et al., Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell. 1996 May 17;85(4):525-35
(Latest) J:216140 Hanson MG, et al., Peripheral nervous system defects in a mouse model for peroxisomal biogenesis disorders. Dev Biol. 2014 Nov 1;395(1):84-95
All references(79)
Other
accession IDs
MGI:2139787

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory