Sv2a
Gene Detail

Symbol Name ID

Sv2a synaptic vesicle glycoprotein 2 a MGI:1927139

Feature Type

protein coding gene

Genetic Map

Chromosome 3

41.65 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:96181151-96195521 bp, + strand From VEGA annotation of GRCm38   14371 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32237  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: synaptic vesicle protein SV2
Gene Tree: Sv2a

Human homologs

Human Homolog		SV2A, synaptic vesicle glycoprotein 2A
NCBI Gene ID		9900
neXtProt AC		NX_Q7L0J3
Human Synonyms		SV2
Human Chr (Location)		1q21.2; chr1:149874870-149889434 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Homozygotes for targeted null mutations exhibit seizures, retarded growth, and reduced hippocampal (GABA)ergic neurotransmission. Many mutants die shortly after birth, and all are dead by three weeks of age.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	cellular calcium ion homeostasis, neurotransmitter transport, ...
Component	cell-cell junction, cell junction, ...
Function	receptor activity, transmembrane transporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (23 records)
Data Summary: Results (108)    Tissues (100)    Images (23)
Theiler Stages: 21, 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	9
RNA in situ	92
Western blot	7

cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(10)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021899 (Evidence)
Ensembl Gene Model	ENSMUSG00000038486 (Evidence)
Entrez Gene	64051 (Evidence)
DFCI	TC1574014, TC1660787
DoTS	DT.489464
NIA Mouse Gene Index	U003591
Consensus CDS Project	CCDS17631.1
International Mouse Knockout Project Status	Sv2a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021899	VEGA Gene Model | MGI Sequence Detail	14371	C57BL/6J
transcript	OTTMUST00000052009	VEGA | MGI Sequence Detail	4334	Not Applicable
polypeptide	OTTMUSP00000024563	VEGA | MGI Sequence Detail	742	Not Applicable

All sequences(29) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(28 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005828	General substrate transporter
InterPro	IPR011701	Major facilitator superfamily
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
InterPro	IPR005829	Sugar transporter, conserved site
InterPro	IPR022308	Synaptic vesicle protein SV2, chordata
Protein Ontology	PR:000015849	synaptic vesicle glycoprotein 2A

References

(Earliest) J:33098 Gautam M, et al., Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell. 1996 May 17;85(4):525-35
(Latest) J:185531 Wu H, et al., beta-Catenin gain of function in muscles impairs neuromuscular junction formation. Development. 2012 Jul;139(13):2392-404
All references(73)

Other accession IDs

MGI:2139787