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Sv2a
Gene Detail
 Symbol
Name
ID
Sv2a
synaptic vesicle glycoprotein 2 a
MGI:1927139
Feature Type protein coding gene
Genetic Map
Chromosome 3
41.65 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:96181151-96195521 bp, + strand
From VEGA annotation of GRCm38

  14371 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32237  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: synaptic vesicle protein SV2
Gene Tree: Sv2a

Human
homologs
Human Homolog SV2A, synaptic vesicle glycoprotein 2A
NCBI Gene ID 9900
neXtProt AC  NX_Q7L0J3
Human Synonyms  SV2
Human Chr (Location)  1q21.2; chr1:149903318-149917882 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit seizures, retarded growth, and reduced hippocampal (GABA)ergic neurotransmission. Many mutants die shortly after birth, and all are dead by three weeks of age.
 
Interactions
Sv2a interacts with 295 markers (Mir15a, Mir16-1, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cellular calcium ion homeostasis, neurotransmitter transport, ...
Component cell-cell junction, cell junction, ...
Function receptor activity, transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (108)    Tissues (100)    Images (23)
Theiler Stages: 21, 22, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 9
RNA in situ 92
Western blot 7
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021899 (Evidence)
Ensembl Gene ModelENSMUSG00000038486 (Evidence)
Entrez Gene64051 (Evidence)
DFCITC1574014, TC1660787
DoTSDT.489464
NIA Mouse Gene IndexU003591
Consensus CDS ProjectCCDS17631.1
International Mouse Knockout Project StatusSv2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021899 VEGA Gene Model | MGI Sequence Detail 14371 C57BL/6J ±  kb
transcript OTTMUST00000052009 VEGA | MGI Sequence Detail 4334 Not Applicable 
polypeptide OTTMUSP00000024563 VEGA | MGI Sequence Detail 742 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(33 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 General substrate transporter
InterPro IPR011701 Major facilitator superfamily
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
InterPro IPR001646 Pentapeptide repeat
InterPro IPR005829 Sugar transporter, conserved site
InterPro IPR022308 Synaptic vesicle protein SV2
Protein Ontology PR:000015849 synaptic vesicle glycoprotein 2A
References (Earliest) J:33098 Gautam M, et al., Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell. 1996 May 17;85(4):525-35
(Latest) J:204383 Yao J, et al., Loss of the SV2-like protein SVOP produces no apparent deficits in laboratory mice. PLoS One. 2013;8(7):e68215
All references(78)
Other
accession IDs
MGI:2139787

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory