Slc5a7
Gene Detail

Symbol Name ID

Slc5a7 solute carrier family 5 (choline transporter), member 7 MGI:1927126

Synonyms

CHT1

Feature Type

protein coding gene

Genetic Map

Chromosome 17

28.23 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:54273594-54299034 bp, - strand From Ensembl annotation of GRCm38   25441 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32516  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Slc5a7

Human homologs

Human Homolog		SLC5A7, solute carrier family 5 (choline transporter), member 7
NCBI Gene ID		60482
neXtProt AC		NX_Q9GZV3
Human Synonyms		CHT, CHT1, hCHT, HMN7A
Human Chr (Location)		2q12; chr2:108602995-108630439 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC5A7

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous null mice display neonatal lethality with respiratory failure, hyporesponsiveness to touch, inability to sustain acetylcholine release, and abnormal neuromuscular junction morphology.

 

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	acetylcholine biosynthetic process, choline transport, ...
Component	integral to membrane, membrane, ...
Function	choline binding, choline:sodium symporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (104)    Tissues (26)    Images (12)
Theiler Stages: 22, 23, 26, 28

Assay Type	Results
RNA in situ	21
Western blot	35
RT-PCR	48

cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(8) Primer pair(2)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000023945 (Evidence)
Entrez Gene	63993 (Evidence)
UniGene	155241
DFCI	TC1587528
DoTS	DT.101315234, DT.91336381
NIA Mouse Gene Index	U037926
Consensus CDS Project	CCDS28885.1
International Mouse Knockout Project Status	Slc5a7

Sequences

Length	Strain/Species
genomic	ENSMUSG00000023945	Ensembl Gene Model | MGI Sequence Detail	25441	C57BL/6J
transcript	ENSMUST00000095712	Ensembl | MGI Sequence Detail	5176	Not Applicable
polypeptide	ENSMUSP00000093379	Ensembl | MGI Sequence Detail	580	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(227 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001734	Sodium/solute symporter
Protein Ontology	PR:000015173	high affinity choline transporter 1

References

(Earliest) J:69663 Wang Y, et al., Molecular cloning of a cDNA for a putative choline co-transporter from Limulus CNS. Gene. 2001 May 2;268(1-2):123-31
(Latest) J:194277 Parikh V, et al., The presynaptic choline transporter imposes limits on sustained cortical acetylcholine release and attention. J Neurosci. 2013 Feb 6;33(6):2326-37
All references(45)