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Rplp1 Gene Detail
Summary
  • Symbol
    Rplp1
  • Name
    ribosomal protein, large, P1
  • Synonyms
    2410042H16Rik, acidic ribosomal phosphoprotein P1, C430017H15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927099
    NCBI Gene: 56040
  • Gene Overview
    MyGene.info: RPLP1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:61913283-61914510 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 33.50 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927099
protein coding gene Chr9:61913283-61914542 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034915
protein coding gene Chr9:61413870-61415124 (-)
A/J MGP_AJ_G0034895
protein coding gene Chr9:59409902-59411156 (-)
AKR/J MGP_AKRJ_G0034825
protein coding gene Chr9:60778353-60779607 (-)
BALB/cJ MGP_BALBcJ_G0034888
protein coding gene Chr9:59127706-59128960 (-)
C3H/HeJ MGP_C3HHeJ_G0034598
protein coding gene Chr9:61273571-61274825 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035407
protein coding gene Chr9:63070531-63071785 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032318
protein coding gene Chr9:59089611-59090846 (-)
CAST/EiJ MGP_CASTEiJ_G0033919
protein coding gene Chr9:61396519-61399149 (-)
CBA/J MGP_CBAJ_G0034569
protein coding gene Chr9:65264098-65265352 (-)
DBA/2J MGP_DBA2J_G0034728
protein coding gene Chr9:59210388-59211642 (-)
FVB/NJ MGP_FVBNJ_G0034670
protein coding gene Chr9:58493015-58494269 (-)
LP/J MGP_LPJ_G0034811
protein coding gene Chr9:61707025-61708279 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034713
protein coding gene Chr9:66681483-66682737 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035429
protein coding gene Chr9:60852350-60853604 (-)
PWK/PhJ MGP_PWKPhJ_G0033623
protein coding gene Chr9:59318046-59319424 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033456
protein coding gene Chr9:61133305-61134550 (-)
WSB/EiJ MGP_WSBEiJ_G0034032
protein coding gene Chr9:60756375-60757629 (-)



Homology
more
  • Human Ortholog
    RPLP1, ribosomal protein lateral stalk subunit P1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    RPLP1, ribosomal protein lateral stalk subunit P1
    Orthology source: HGNC
  • Synonyms
    LP1, P1, RPP1
  • Links
    NCBI Gene ID: 6176
    neXtProt AC: NX_P05386
    UniProt: P05386

  • Chr Location
    15q23; chr15:69452820-69455545 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele exhibit partial postnatal lethality, male infertility, perforations in the small and large intestine, impaired hematopoiesis, and abnormal tail development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56040 NCBI Gene Model | MGI Sequence Detail 1228 C57BL/6J ±  kb
transcript NM_018853 RefSeq | MGI Sequence Detail 468 C57BL/6  
polypeptide P47955 UniProt | EBI | MGI Sequence Detail 114 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR027534 Ribosomal protein L12 family
    IPR038716 Ribosomal protein P1/P2, N-terminal domain
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 5
Other
Accession IDs
less
MGI:1914316, MGI:1925856
References
more
  • Summaries
    All 34
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:63377 Abidari JM, et al., Identification of novel genes expressed during metanephric induction through single-cell library screening. Kidney Int. 2000 Jun;57(6):2221-8
  • Latest
    J:218949 Perucho L, et al., RPLP1, a crucial ribosomal protein for embryonic development of the nervous system. PLoS One. 2014;9(6):e99956

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory