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Cyp39a1 Gene Detail
Summary
  • Symbol
    Cyp39a1
  • Name
    cytochrome P450, family 39, subfamily a, polypeptide 1
  • Synonyms
    oxysterol 7-alpha-hydroxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927096
    NCBI Gene: 56050
  • Gene Overview
    MyGene.info: CYP39A1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:43667425-43751431 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 19.75 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    872 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927096
protein coding gene Chr17:43667372-43751431 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023779
protein coding gene Chr17:44569314-44660771 (+)
A/J MGP_AJ_G0023737
protein coding gene Chr17:43563922-43644339 (+)
AKR/J MGP_AKRJ_G0023708
protein coding gene Chr17:43807007-43899819 (+)
BALB/cJ MGP_BALBcJ_G0023741
protein coding gene Chr17:43454854-43534582 (+)
C3H/HeJ MGP_C3HHeJ_G0023505
protein coding gene Chr17:44502362-44593251 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024184
protein coding gene Chr17:46552249-46642415 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021634
protein coding gene Chr17:40390919-40476262 (+)
CAST/EiJ MGP_CASTEiJ_G0022986
protein coding gene Chr17:44541192-44637513 (+)
CBA/J MGP_CBAJ_G0023481
protein coding gene Chr17:48190284-48288758 (+)
DBA/2J MGP_DBA2J_G0023607
protein coding gene Chr17:42365743-42452076 (+)
FVB/NJ MGP_FVBNJ_G0023574
protein coding gene Chr17:41928420-42022268 (+)
LP/J MGP_LPJ_G0023688
protein coding gene Chr17:45235810-45317859 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023603
protein coding gene Chr17:47835795-47926025 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024229
protein coding gene Chr17:44157063-44247637 (+)
PWK/PhJ MGP_PWKPhJ_G0022731
protein coding gene Chr17:41620390-41702689 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022546
protein coding gene Chr17:41022772-41111908 (+)
WSB/EiJ MGP_WSBEiJ_G0023051
protein coding gene Chr17:44680120-44769962 (+)



Homology
more
  • Human Ortholog
    CYP39A1, cytochrome P450 family 39 subfamily A member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CYP39A1, cytochrome P450 family 39 subfamily A member 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 51302
    neXtProt AC: NX_Q9NYL5
    UniProt: Q9NYL5

  • Chr Location
    6p12.3; chr6:46549580-46652849 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023963 Ensembl Gene Model | MGI Sequence Detail 84007 C57BL/6J ±  kb
transcript ENSMUST00000170988 Ensembl | MGI Sequence Detail 3053 Not Applicable  
polypeptide ENSMUSP00000130073 Ensembl | MGI Sequence Detail 470 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:62589 Li-Hawkins J, et al., Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. J Biol Chem. 2000 Jun 2;275(22):16543-9
  • Latest
    J:256166 Creasy KT, et al., Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver. Gene Expr. 2016;17(1):7-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory