Myo1g MGI Mouse Gene Detail - MGI:1927091

Symbol

Myo1g
Name

myosin IG
Synonyms

E430002D17Rik

Feature Type

protein coding gene
IDs

MGI:1927091
NCBI Gene: 246177
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:6456548-6470960 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 4.30 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

691 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927091	protein coding gene	Chr11:6456548-6470965 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018025	protein coding gene	Chr11:3645799-3660195 (-)
A/J	MGP_AJ_G0017998	protein coding gene	Chr11:3483517-3497928 (-)
AKR/J	MGP_AKRJ_G0017962	protein coding gene	Chr11:3663061-3677472 (-)
BALB/cJ	MGP_BALBcJ_G0017966	protein coding gene	Chr11:3496226-3510630 (-)
C3H/HeJ	MGP_C3HHeJ_G0017779	protein coding gene	Chr11:3535134-3549587 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018418	protein coding gene	Chr11:3736718-3751135 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016076	protein coding gene	Chr11:3369109-3383676 (-)
CAST/EiJ	MGP_CASTEiJ_G0017341	protein coding gene	Chr11:3537214-3551826 (-)
CBA/J	MGP_CBAJ_G0017754	protein coding gene	Chr11:4160913-4175330 (-)
DBA/2J	MGP_DBA2J_G0017864	protein coding gene	Chr11:3387322-3401739 (-)
FVB/NJ	MGP_FVBNJ_G0017856	protein coding gene	Chr11:3419495-3433905 (-)
LP/J	MGP_LPJ_G0017935	protein coding gene	Chr11:3716424-3730828 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017882	protein coding gene	Chr11:3714841-3729252 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018458	protein coding gene	Chr11:3675058-3689475 (-)
PWK/PhJ	MGP_PWKPhJ_G0017121	protein coding gene	Chr11:3433953-3448349 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016918	protein coding gene	Chr11:3619644-3634078 (-)
WSB/EiJ	MGP_WSBEiJ_G0017395	protein coding gene	Chr11:3499584-3513980 (-)

Human Ortholog

MYO1G, myosin IG

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYO1G, myosin IG
Synonyms

HA2, HLA-HA2, MHAG
Links

HGNC:13880

NCBI Gene ID: 64005

UniProt: B0I1T2
Chr Location

7p13; chr7:44962662-44979088 (-) GRCh38

MGI Vertebrate Homology

Myo1g stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MYO1G
Gene Tree

Myo1g

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Phenotype Summary

12 phenotypes from 2 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Gene trapped

2
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced B cell spreading, migration and homing and impaired T cell motility.

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All GO Annotations

47
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

38

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

58
RefSeq

7
UniProt

4
CCDS

CCDS24421.1

Ensembl

ENSMUSG00000020437 (Evidence)
NCBI Gene

246177

			Length	Strain/Species	Flank
genomic	246177	NCBI Gene Model \| MGI Sequence Detail	14413	C57BL/6J	± kb
transcript	NM_178440	RefSeq \| MGI Sequence Detail	3307	C57BL/6
polypeptide	Q5SUA5	UniProt \| EBI \| MGI Sequence Detail	1024	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010861 myosin-Ig

(term hierarchy)
InterPro Domains

IPR036072 Class I myosin, motor domain

IPR010926 Class I myosin tail homology domain

IPR036961 Kinesin motor domain superfamily

IPR001609 Myosin head, motor domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q5SUA5 2 sites, 1 O-linked glycan (1 site)

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All nucleic 38

cDNA 38

Microarray probesets 3

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MGI:2442411

Summaries

All 44

Gene Ontology 11

Phenotypes 13
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Myo1g:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106733	Chr11:6472848-6472854 (-)	-1,891 bp
Tssr106732	Chr11:6472782-6472786 (-)	-1,824 bp
Tssr106731	Chr11:6470894-6470969 (-)	28 bp
Tssr106730	Chr11:6470872-6470891 (-)	78 bp
Tssr106729	Chr11:6470864-6470866 (-)	95 bp
Tssr106728	Chr11:6470844-6470851 (-)	112 bp
Tssr106727	Chr11:6469800-6469828 (-)	1,146 bp
Tssr106726	Chr11:6469769-6469789 (-)	1,181 bp
Tssr106725	Chr11:6469497-6469513 (-)	1,455 bp
Tssr106724	Chr11:6469168-6469180 (-)	1,786 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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