Ube4b
Gene Detail

Symbol Name ID

Ube4b ubiquitination factor E4B MGI:1927086

Synonyms

4930551I19Rik, 4933406G05Rik, D4Bwg0973e, mKIAA0684, UFD2, UFD2a, Ufd2p

Feature Type

protein coding gene

Genetic Map

Chromosome 4

79.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr4:149328416-149426749 bp, - strand From VEGA annotation of GRCm38   98334 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:107623  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ubiquitin conjugation factor E4 with U-box domain, Ufd2 type
Gene Tree: Ube4b

Human homologs

Human Homolog		UBE4B, ubiquitination factor E4B
NCBI Gene ID		10277
neXtProt AC		NX_O95155
Human Synonyms		E4, HDNB1, UBOX3, UFD2, UFD2A
Human Chr (Location)		1p36.3; chr1:10032983-10181239 (+)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(136) : Gene trapped(132) Spontaneous(1) Targeted(3)
Genomic Mutations involving Ube4b (1)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a disruption in this gene die by midgestation and exhibit cardiac development defects such as hemorrhage and cardiomyocyte apoptosis. Heterozygous mice exhibit axonal dystrophy in the nucleus gracilis, degeneration of Purkinje cells and gait abnormalities.

 

Interactions

Ube4b interacts with 354 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	cellular protein catabolic process, granzyme-mediated apoptotic signaling pathway, ...
Component	nucleus
Function	ATP binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (130)    Tissues (130)    Images (20)
Theiler Stages: 22, 26, 28

Assay Type	Results
RNA in situ	130

cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(19) Genomic(1) cDNA(16) Primer pair(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000010171 (Evidence)
Ensembl Gene Model	ENSMUSG00000028960 (Evidence)
Entrez Gene	63958 (Evidence)
Consensus CDS Project	CCDS18958.1
International Mouse Knockout Project Status	Ube4b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010171	VEGA Gene Model | MGI Sequence Detail	98334	C57BL/6J
transcript	OTTMUST00000023653	VEGA | MGI Sequence Detail	5626	Not Applicable
polypeptide	OTTMUSP00000010808	VEGA | MGI Sequence Detail	1173	Not Applicable

All sequences(73) RefSeq(14)

Polymorphisms

SNPs within 2kb(797 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000016996	ubiquitin conjugation factor E4 B

References

(Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:194233 Starita LM, et al., Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):E1263-72
All references(49)

Other accession IDs

MGD-MRK-34203, MGI:106509, MGI:1921672, MGI:1922586, MGI:2140420