Ube4b MGI Mouse Gene Detail - MGI:1927086 - ubiquitination factor E4B

Symbol

Ube4b
Name

ubiquitination factor E4B
Synonyms

4930551I19Rik, 4933406G05Rik, D4Bwg0973e, mKIAA0684, UFD2, UFD2a, Ufd2p

Feature Type

protein coding gene
IDs

MGI:1927086
NCBI Gene: 63958
Gene Overview

MyGene.info: UBE4B
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr4:149328416-149426749 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 79.08 cM
Mapping Data

4 experiments

SNPs within 2kb

787 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927086	protein coding gene	Chr4:149328416-149428161 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029138	protein coding gene	Chr4:153166854-153272563 (-)
A/J	MGP_AJ_G0029103	protein coding gene	Chr4:146775592-146877521 (-)
AKR/J	MGP_AKRJ_G0029051	protein coding gene	Chr4:150796481-150904108 (-)
BALB/cJ	MGP_BALBcJ_G0029119	protein coding gene	Chr4:147281044-147380543 (-)
C3H/HeJ	MGP_C3HHeJ_G0028840	protein coding gene	Chr4:151359187-151462195 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029568	protein coding gene	Chr4:158691766-158802416 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026814	protein coding gene	Chr4:139192619-139297288 (-)
CAST/EiJ	MGP_CASTEiJ_G0028253	protein coding gene	Chr4:148583368-148692057 (-)
CBA/J	MGP_CBAJ_G0028802	protein coding gene	Chr4:163351623-163470619 (-)
DBA/2J	MGP_DBA2J_G0028951	protein coding gene	Chr4:146889488-146989037 (-)
FVB/NJ	MGP_FVBNJ_G0028915	protein coding gene	Chr4:145992481-146095306 (-)
LP/J	MGP_LPJ_G0029041	protein coding gene	Chr4:153091756-153196837 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028942	protein coding gene	Chr4:166603419-166713524 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029600	protein coding gene	Chr4:151297748-151400702 (-)
PWK/PhJ	MGP_PWKPhJ_G0027973	protein coding gene	Chr4:142891085-142991245 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027807	protein coding gene	Chr4:145533132-145639160 (-)
WSB/EiJ	MGP_WSBEiJ_G0028333	protein coding gene	Chr4:151451968-151554070 (-)

Human Ortholog

UBE4B, ubiquitination factor E4B

Vertebrate Orthologs

10

Human Ortholog

UBE4B, ubiquitination factor E4B
Orthology source: HomoloGene, HGNC
Synonyms

E4, HDNB1, UBOX3, UFD2, UFD2A
Links

HGNC:12500

NCBI Gene ID: 10277

neXtProt AC: NX_O95155

UniProt: O95155
Chr Location

1p36.22; chr1:10032983-10181239 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 107623
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: UBE4B
Protein SuperFamily

ubiquitin conjugation factor E4 with U-box domain, Ufd2 type
Gene Tree

Ube4b

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Phenotype Summary

19 phenotypes from 1 allele in 1 genetic background
123 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

137
Gene trapped

132
Spontaneous

1
Targeted

4
Genomic Mutations

2 involving Ube4b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a disruption in this gene die by midgestation and exhibit cardiac development defects such as hemorrhage and cardiomyocyte apoptosis. Heterozygous mice exhibit axonal dystrophy in the nucleus gracilis, degeneration of Purkinje cells and gait abnormalities.

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All GO Annotations

34
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

130
Tissues

130
cDNA Data

15
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ube4b

ZFIN ube4b

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Ube4b interacts with 353 markers (Mir1a-1, Mir1a-2, Mir9-1, ...) View All

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All Sequences

70
RefSeq

6
UniProt

1
CCDS

CCDS18958.1

Ensembl

ENSMUSG00000028960 (Evidence)
NCBI Gene

63958 (Evidence)

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028960	Ensembl Gene Model \| MGI Sequence Detail	98334	C57BL/6J	± kb
transcript	ENSMUST00000238439	Ensembl \| MGI Sequence Detail	4943	Not Applicable
polypeptide	ENSMUSP00000158654	Ensembl \| MGI Sequence Detail	1307	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016996 ubiquitin conjugation factor E4 B

(term hierarchy)

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All nucleic 20

Genomic 1

cDNA 17

Primer pair 2

Microarray probesets 7

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MGD-MRK-34203, MGI:106509, MGI:1921672, MGI:1922586, MGI:2140420

Summaries

All 165

Developmental Gene Expression 5

Gene Ontology 9

Phenotypes 123
Earliest

J:19951 Lunn ER, et al., Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve. Eur J Neurosci. 1989 Jan;1(1):27-33
Latest

J:280442 Fernandes KA, et al., Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury. Exp Eye Res. 2018 Jun;171:54-61

TSS for Ube4b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr44655	Chr4:149426603-149426638 (-)	128 bp
Tssr44654	Chr4:149426398-149426423 (-)	338 bp
Tssr44653	Chr4:149426373-149426393 (-)	366 bp
Tssr44652	Chr4:149426354-149426366 (-)	389 bp
Tssr44651	Chr4:149426262-149426271 (-)	482 bp
Tssr44650	Chr4:149426229-149426242 (-)	513 bp
Tssr44648	Chr4:149399380-149399398 (-)	27,360 bp
Tssr44646	Chr4:149351708-149351721 (-)	75,034 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/04/2020 MGI 6.14