Ube4b MGI Mouse Gene Detail - MGI:1927086 - ubiquitination factor E4B

Ube4b Gene Detail

Symbol

Ube4b
Name

ubiquitination factor E4B
Synonyms

4930551I19Rik, 4933406G05Rik, D4Bwg0973e, mKIAA0684, UFD2, UFD2a, Ufd2p

Feature Type

protein coding gene
IDs

MGI:1927086
NCBI Gene: 63958
Gene Overview

MyGene.info: UBE4B

Sequence Map

Chr4:149328416-149426749 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

98334 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 79.08 cM
Mapping Data

4 experiments

Human Ortholog

UBE4B, ubiquitination factor E4B

Vertebrate Orthologs

10

Human Ortholog

UBE4B, ubiquitination factor E4B
Orthology source: HomoloGene, HGNC
Synonyms

E4, HDNB1, UBOX3, UFD2, UFD2A
Links

HGNC:12500

NCBI Gene ID: 10277

neXtProt AC: NX_O95155

UniProt: O95155
Chr Location

1p36.22; chr1:10032983-10181239 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 107623
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: UBE4B
Protein SuperFamily

ubiquitin conjugation factor E4 with U-box domain, Ufd2 type
Gene Tree

Ube4b

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Phenotype Summary

19 phenotypes from 1 allele in 1 genetic background
116 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

137
Gene trapped

132
Spontaneous

1
Targeted

4
Genomic Mutations

2 involving Ube4b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

56 strains or lines available

Mice homozygous for a disruption in this gene die by midgestation and exhibit cardiac development defects such as hemorrhage and cardiomyocyte apoptosis. Heterozygous mice exhibit axonal dystrophy in the nucleus gracilis, degeneration of Purkinje cells and gait abnormalities.

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All GO Annotations

30
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

130
Tissues

130
cDNA Data

14
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ube4b

ZFIN ube4b

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Ube4b interacts with 353 markers (Mir1a-1, Mir1a-2, Mir9-1, ...) View All

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All Sequences

67
RefSeq

6
UniProt

1
CCDS

CCDS18958.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000010171	VEGA Gene Model \| MGI Sequence Detail	98334	C57BL/6J	± kb
transcript	OTTMUST00000023653	VEGA \| MGI Sequence Detail	5626	Not Applicable
polypeptide	OTTMUSP00000010808	VEGA \| MGI Sequence Detail	1173	Not Applicable

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SNPs within 2kb

787 from dbSNP Build 142

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UniProt

1 Sequence
Protein Ontology

PR:000016996 ubiquitin conjugation factor E4 B

(term hierarchy)

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All nucleic 19

Genomic 1

cDNA 16

Primer pair 2

Microarray probesets 7

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MGD-MRK-34203, MGI:106509, MGI:1921672, MGI:1922586, MGI:2140420

Summaries

All 158

Developmental Gene Expression 5

Gene Ontology 9

Phenotypes 116
Earliest

J:19951 Lunn ER, et al., Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve. Eur J Neurosci. 1989 Jan;1(1):27-33
Latest

J:242217 Harder JM, et al., Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective. Proc Natl Acad Sci U S A. 2017 May 09;114(19):E3839-E3848

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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