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Ube4b Gene Detail
Summary
  • Symbol
    Ube4b
  • Name
    ubiquitination factor E4B
  • Synonyms
    4930551I19Rik, 4933406G05Rik, D4Bwg0973e, mKIAA0684, UFD2, UFD2a, Ufd2p
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927086
    NCBI Gene: 63958
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:149412873-149511206 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 79.08 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1127 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927086
 protein coding gene Chr4:149412873-149512618 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029138
 protein coding gene Chr4:153166854-153272563 (-)
A/J MGP_AJ_G0029103
 protein coding gene Chr4:146775592-146877521 (-)
AKR/J MGP_AKRJ_G0029051
 protein coding gene Chr4:150796481-150904108 (-)
BALB/cJ MGP_BALBcJ_G0029119
 protein coding gene Chr4:147281044-147380543 (-)
C3H/HeJ MGP_C3HHeJ_G0028840
 protein coding gene Chr4:151359187-151462195 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029568
 protein coding gene Chr4:158691766-158802416 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026814
 protein coding gene Chr4:139192619-139297288 (-)
CAST/EiJ MGP_CASTEiJ_G0028253
 protein coding gene Chr4:148583368-148692057 (-)
CBA/J MGP_CBAJ_G0028802
 protein coding gene Chr4:163351623-163470619 (-)
DBA/2J MGP_DBA2J_G0028951
 protein coding gene Chr4:146889488-146989037 (-)
FVB/NJ MGP_FVBNJ_G0028915
 protein coding gene Chr4:145992481-146095306 (-)
LP/J MGP_LPJ_G0029041
 protein coding gene Chr4:153091756-153196837 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028942
 protein coding gene Chr4:166603419-166713524 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029600
 protein coding gene Chr4:151297748-151400702 (-)
PWK/PhJ MGP_PWKPhJ_G0027973
 protein coding gene Chr4:142891085-142991245 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027807
 protein coding gene Chr4:145533132-145639160 (-)
WSB/EiJ MGP_WSBEiJ_G0028333
 protein coding gene Chr4:151451968-151554070 (-)



Homology
more
  • Human Ortholog
    UBE4B, ubiquitination factor E4B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBE4B, ubiquitination factor E4B
  • Synonyms
    E4, HDNB1, UBOX3, UFD2, UFD2A
  • Links
    NCBI Gene ID: 10277
    UniProt: O95155

  • Chr Location
    1p36.22; chr1:10032832-10181239 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    136 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene die by midgestation and exhibit cardiac development defects such as hemorrhage and cardiomyocyte apoptosis. Heterozygous mice exhibit axonal dystrophy in the nucleus gracilis, degeneration of Purkinje cells and gait abnormalities. mice homozygous for a conditional allele activated in neurons exhibit reduced NPC proliferation, reduced weight, abnormal dendrite arborization, seizures, and postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    871
  • Tissues
    146
  • cDNA Data
    15
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028960 Ensembl Gene Model | MGI Sequence Detail 98334 C57BL/6J ±  kb
    transcript ENSMUST00000239095 Ensembl | MGI Sequence Detail 5081 Not Applicable  
    polypeptide ENSMUSP00000158872 Ensembl | MGI Sequence Detail 1353 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 17
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-34203, MGI:106509, MGI:1921672, MGI:1922586, MGI:2140420
    References
    more
    • Summaries
      All 188
      Developmental Gene Expression 7
      Gene Ontology 17
      Phenotypes 136
    • Earliest
      J:19951 Lunn ER, et al., Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve. Eur J Neurosci. 1989 Jan;1(1):27-33
    • Latest
      J:332664 Jin S, et al., Downregulation of UBE4B promotes CNS axon regrowth and functional recovery after stroke. iScience. 2023 Jan 20;26(1):105885
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    03/25/2025
    MGI 6.24     		The Jackson Laboratory