About   Help   FAQ
Ube4b Gene Detail
Summary
  • Symbol
    Ube4b
  • Name
    ubiquitination factor E4B
  • Synonyms
    4930551I19Rik, 4933406G05Rik, D4Bwg0973e, mKIAA0684, UFD2, UFD2a, Ufd2p
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927086
    NCBI Gene: 63958
  • Gene Overview
    MyGene.info: UBE4B
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr4:149328416-149426749 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      98334 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 79.08 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    UBE4B, ubiquitination factor E4B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UBE4B, ubiquitination factor E4B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    E4, HDNB1, UBOX3, UFD2, UFD2A
  • Links
    NCBI Gene ID: 10277
    neXtProt AC: NX_O95155
    UniProt: O95155

  • Chr Location
    1p36.22; chr1:10032983-10181239 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    119 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene die by midgestation and exhibit cardiac development defects such as hemorrhage and cardiomyocyte apoptosis. Heterozygous mice exhibit axonal dystrophy in the nucleus gracilis, degeneration of Purkinje cells and gait abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    130
  • Tissues
    130
  • cDNA Data
    14
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000010171 VEGA Gene Model | MGI Sequence Detail 98334 C57BL/6J ±  kb
    transcript OTTMUST00000023653 VEGA | MGI Sequence Detail 5626 Not Applicable  
    polypeptide OTTMUSP00000010808 VEGA | MGI Sequence Detail 1173 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      787 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 1
      cDNA 16
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-34203, MGI:106509, MGI:1921672, MGI:1922586, MGI:2140420
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 119
    • Earliest
      J:19951 Lunn ER, et al., Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve. Eur J Neurosci. 1989 Jan;1(1):27-33
    • Latest
      J:252071 Gilley J, et al., Sarm1 Deletion, but Not Wld(S), Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy. Cell Rep. 2017 Oct 3;21(1):10-16
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    05/08/2018
    MGI 6.12     		The Jackson Laboratory