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Ube4b
Gene Detail
Symbol

Name
ID
Ube4b
ubiquitination factor E4B
MGI:1927086
Synonyms
4930551I19Rik, 4933406G05Rik, D4Bwg0973e, mKIAA0684, UFD2, UFD2a, Ufd2p
Feature Type
protein coding gene
Genetic Map
Chromosome 4
79.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:149328416-149426749 bp, - strand
From VEGA annotation of GRCm38

  98334 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:107623  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UBE4B
Protein SuperFamily: ubiquitin conjugation factor E4 with U-box domain, Ufd2 type
Gene Tree: Ube4b

Human
homologs
UBE4B, ubiquitination factor E4B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10277
neXtProt AC: NX_O95155

Human Synonyms: E4, HDNB1, UBOX3, UFD2, UFD2A

Human Chr (Location): 1p36.3; chr1:10032983-10181239 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(137) : Gene trapped(132) Spontaneous(1) Targeted(4)
Genomic Mutations involving Ube4b (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a disruption in this gene die by midgestation and exhibit cardiac development defects such as hemorrhage and cardiomyocyte apoptosis. Heterozygous mice exhibit axonal dystrophy in the nucleus gracilis, degeneration of Purkinje cells and gait abnormalities.
 
Interactions
Ube4b interacts with 353 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cellular protein catabolic process, granzyme-mediated apoptotic signaling pathway, ...
Component nucleus
Function ATPase binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (130)    Tissues (130)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 130
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ube4b ; ZFIN ube4b    NEW 
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(16) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000010171 (Evidence)
Ensembl Gene Model ENSMUSG00000028960 (Evidence)
Entrez Gene 63958 (Evidence)
Consensus CDS Project CCDS18958.1
International Mouse Phenotyping Consortium Status Ube4b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010171 VEGA Gene Model | MGI Sequence Detail 98334 C57BL/6J ±  kb
transcript OTTMUST00000023653 VEGA | MGI Sequence Detail 5626 Not Applicable 
polypeptide OTTMUSP00000010808 VEGA | MGI Sequence Detail 1173 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(10)
Polymorphisms
SNPs within 2kb(797 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000016996 ubiquitin conjugation factor E4 B
References
(Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:208600 Hunter CS, et al., Islet alpha-, beta-, and delta-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor. Diabetes. 2013 Mar;62(3):875-86
All references(50)
Other
accession IDs
MGD-MRK-34203, MGI:106509, MGI:1921672, MGI:1922586, MGI:2140420

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory