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Ube4b
Gene Detail
 Symbol
Name
ID
Ube4b
ubiquitination factor E4B
MGI:1927086
Synonyms 4930551I19Rik, 4933406G05Rik, D4Bwg0973e, mKIAA0684, UFD2, UFD2a, Ufd2p
Feature Type protein coding gene
Genetic Map
Chromosome 4
79.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:149328416-149426749 bp, - strand
From VEGA annotation of GRCm38

  98334 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:107623  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ubiquitin conjugation factor E4 with U-box domain, Ufd2 type
Gene Tree: Ube4b

Human
homologs
Human Homolog UBE4B, ubiquitination factor E4B
NCBI Gene ID 10277
neXtProt AC  NX_O95155
Human Synonyms  E4, HDNB1, UBOX3, UFD2, UFD2A
Human Chr (Location)  1p36.3; chr1:10032983-10181239 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(136) : Gene trapped(132) Spontaneous(1) Targeted(3)
Genomic Mutations involving Ube4b (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a disruption in this gene die by midgestation and exhibit cardiac development defects such as hemorrhage and cardiomyocyte apoptosis. Heterozygous mice exhibit axonal dystrophy in the nucleus gracilis, degeneration of Purkinje cells and gait abnormalities.
 
Interactions
Ube4b interacts with 354 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cellular protein catabolic process, granzyme-mediated apoptotic signaling pathway, ...
Component nucleus
Function ATP binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (130)    Tissues (130)    Images (20)
Theiler Stages: 22, 26, 28
Assay TypeResults
RNA in situ 130
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(16) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000010171 (Evidence)
Ensembl Gene ModelENSMUSG00000028960 (Evidence)
Entrez Gene63958 (Evidence)
Consensus CDS ProjectCCDS18958.1
International Mouse Knockout Project StatusUbe4b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010171 VEGA Gene Model | MGI Sequence Detail 98334 C57BL/6J ±  kb
transcript OTTMUST00000023653 VEGA | MGI Sequence Detail 5626 Not Applicable 
polypeptide OTTMUSP00000010808 VEGA | MGI Sequence Detail 1173 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(14)
Polymorphisms SNPs within 2kb(797 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000016996 ubiquitin conjugation factor E4 B
References (Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:194233 Starita LM, et al., Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):E1263-72
All references(49)
Other
accession IDs
MGD-MRK-34203, MGI:106509, MGI:1921672, MGI:1922586, MGI:2140420

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory