Slc29a1
Gene Detail

Symbol Name ID

Slc29a1 solute carrier family 29 (nucleoside transporters), member 1 MGI:1927073

Synonyms

1200014D21Rik, ENT1, NBMPR-sensitive equilibrative nucleoside transporter

Feature Type

protein coding gene

Genetic Map

Chromosome 17

22.59 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:45585200-45599606 bp, - strand From VEGA annotation of GRCm38   14407 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Slc29a1 ± 2 cM)

Protein SuperFamily: ENT
Gene Tree: Slc29a1

Human ortholog

SLC29A1 solute carrier family 29 (nucleoside transporters), member 1 NCBI Gene ID 2030
Human Synonyms: ENT1
Human Chr6:44187242-44201888 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(75) : Targeted(3) Gene trapped(72)
 

Mice homozygous for a targeted null allele exhibit a slightly decreased body weight, increased alcohol preference and alcohol consumption, and reduced hypnotic and ataxic responses to ethanol associated with a reduction in adenosine tone.

 
Human Diseases Modeled Using Mouse Slc29a1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	nucleoside transport, regulation of excitatory postsynaptic membrane potential, ...
Component	apical plasma membrane, basolateral plasma membrane, ...
Function	nucleoside transmembrane transporter activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (160)    Tissues (52)    Images (56)
Theiler Stages: 10, 18, 19, 23, 25, 28

Assay Type	Results
RNA in situ	140
Northern blot	8
RT-PCR	12

cDNA source data(223)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(228) Genomic(1) cDNA(225) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000036637 (Evidence)
Ensembl Gene Model	ENSMUSG00000023942 (Evidence)
Entrez Gene	63959 (Evidence)
UniGene	29744
DFCI	TC1572393, TC1651116, TC1653804, TC1671747, TC1684212
DoTS	DT.101400435, DT.101400441, DT.101400442, DT.534834, DT.91282776, DT.94293114, DT.94293118, DT.94293132, DT.97392442
NIA Mouse Gene Index	U037837
Consensus CDS Project	CCDS28813.1, CCDS57096.1
International Mouse Knockout Project Status	Slc29a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036637	VEGA Gene Model | MGI Sequence Detail	14407	C57BL/6J
transcript	OTTMUST00000093940	VEGA | MGI Sequence Detail	2092	Not Applicable
polypeptide	OTTMUSP00000052199	VEGA | MGI Sequence Detail	460	Not Applicable

All sequences(185) RefSeq(10) UniProt(16)

Polymorphisms

SNPs(25 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002259	Equilibrative nucleoside transporter
Protein Ontology	PR:000015054	equilibrative nucleoside transporter 1

References

(Earliest) J:65172 Choi DS, et al., Genomic organization and expression of the mouse equilibrative, nitrobenzylthioinosine-sensitive nucleoside transporter 1 (ENT1) gene. Biochem Biophys Res Commun. 2000 Oct 14;277(1):200-8
(Latest) J:193277 Li L, et al., Tubuloglomerular feedback and renal function in mice with targeted deletion of the type 1 equilibrative nucleoside transporter. Am J Physiol Renal Physiol. 2013 Feb;304(4):F382-9
All references(52)

Other accession IDs

MGI:1923527, MGI:2146741