About   Help   FAQ
Slc29a1
Gene Detail
 Symbol
Name
ID
Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
MGI:1927073
Synonyms 1200014D21Rik, ENT1, NBMPR-sensitive equilibrative nucleoside transporter
Feature Type protein coding gene
Genetic Map
Chromosome 17
22.59 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:45585200-45599606 bp, - strand
From VEGA annotation of GRCm38

  14407 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37985  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: ENT
Gene Tree: Slc29a1

Human
homologs
Human Homolog SLC29A1, solute carrier family 29 (equilibrative nucleoside transporter), member 1
NCBI Gene ID 2030
neXtProt AC  NX_Q99808
Human Synonyms  ENT1
Human Chr (Location)  6p21.1; chr6:44219505-44234151 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(77) : Gene trapped(72) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null allele exhibit a slightly decreased body weight, increased alcohol preference and alcohol consumption, and reduced hypnotic and ataxic responses to ethanol associated with a reduction in adenosine tone.
 
Human Diseases Modeled Using Mouse Slc29a1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Slc29a1 interacts with 72 markers (Mir15a, Mir16-1, Mir29b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process nucleoside transmembrane transport, nucleoside transport, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function nucleoside transmembrane transporter activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (160)    Tissues (52)    Images (56)
Theiler Stages: 10, 18, 19, 23, 25, 28
Assay TypeResults
RNA in situ 140
Northern blot 8
RT-PCR 12
cDNA source data(16)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(1) cDNA(18) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036637 (Evidence)
Ensembl Gene ModelENSMUSG00000023942 (Evidence)
Entrez Gene63959 (Evidence)
DFCITC1572393, TC1651116, TC1653804, TC1671747, TC1684212
DoTSDT.101400435, DT.101400441, DT.101400442, DT.534834, DT.91282776, DT.94293114, DT.94293118, DT.94293132, DT.97392442
NIA Mouse Gene IndexU037837
Consensus CDS ProjectCCDS28813.1, CCDS57096.1
International Mouse Knockout Project StatusSlc29a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036637 VEGA Gene Model | MGI Sequence Detail 14407 C57BL/6J ±  kb
transcript OTTMUST00000093940 VEGA | MGI Sequence Detail 2092 Not Applicable 
polypeptide OTTMUSP00000052199 VEGA | MGI Sequence Detail 460 Not Applicable 

For the selected sequences
All sequences(197) RefSeq(22) UniProt(16)
Polymorphisms SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002259 Equilibrative nucleoside transporter
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
Protein Ontology PR:000015054 equilibrative nucleoside transporter 1
References (Earliest) J:65172 Choi DS, et al., Genomic organization and expression of the mouse equilibrative, nitrobenzylthioinosine-sensitive nucleoside transporter 1 (ENT1) gene. Biochem Biophys Res Commun. 2000 Oct 14;277(1):200-8
(Latest) J:196284 Nam HW, et al., Adenosine transporter ENT1 regulates the acquisition of goal-directed behavior and ethanol drinking through A2A receptor in the dorsomedial striatum. J Neurosci. 2013 Mar 6;33(10):4329-38
All references(53)
Disease annotation references (1)
Other
accession IDs
MGI:1923527, MGI:2146741

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory