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Slc29a1
Gene Detail
Symbol

Name
ID
Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
MGI:1927073
Synonyms
1200014D21Rik, ENT1, NBMPR-sensitive equilibrative nucleoside transporter
Feature Type
protein coding gene
Genetic Map
Chromosome 17
22.59 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:45585200-45599606 bp, - strand
From VEGA annotation of GRCm38

  14407 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37985  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SLC29A1
Protein SuperFamily: ENT
Gene Tree: Slc29a1

Human
homologs
SLC29A1, solute carrier family 29 (equilibrative nucleoside transporter), member 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2030
neXtProt AC: NX_Q99808

Human Synonyms: ENT1

Human Chr (Location): 6p21.1; chr6:44219505-44234151 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(77) : Gene trapped(72) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted null allele exhibit a slightly decreased body weight, increased alcohol preference and alcohol consumption, and reduced hypnotic and ataxic responses to ethanol associated with a reduction in adenosine tone.
 
Human Diseases Modeled in Mice Using Slc29a1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Slc29a1 interacts with 72 markers (Mir15a, Mir16-1, Mir29b-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (160)    Tissues (52)    Images (56)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 140
Northern blot 8
RT-PCR 12
cDNA source data(16)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase slc29a1 ; ZFIN slc29a1a    NEW 
Molecular
reagents
All nucleic(21) Genomic(1) cDNA(18) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000036637 (Evidence)
Ensembl Gene Model ENSMUSG00000023942 (Evidence)
Entrez Gene 63959 (Evidence)
DFCI TC1572393, TC1651116, TC1653804, TC1671747, TC1684212
DoTS DT.101400435, DT.101400441, DT.101400442, DT.534834, DT.91282776, DT.94293114, DT.94293118, DT.94293132, DT.97392442
NIA Mouse Gene Index U037837
Consensus CDS Project CCDS28813.1, CCDS57096.1
International Mouse Phenotyping Consortium Status Slc29a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036637 VEGA Gene Model | MGI Sequence Detail 14407 C57BL/6J ±  kb
transcript OTTMUST00000093940 VEGA | MGI Sequence Detail 2092 Not Applicable 
polypeptide OTTMUSP00000052199 VEGA | MGI Sequence Detail 460 Not Applicable 

For the selected sequences
All sequences(204) RefSeq(22) UniProt(16)
Polymorphisms
SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002259 Equilibrative nucleoside transporter
InterPro IPR030195 Equilibrative nucleoside transporter 1
InterPro IPR020846 Major facilitator superfamily domain
Protein Ontology PR:000015054 equilibrative nucleoside transporter 1
References
(Earliest) J:65172 Choi DS, et al., Genomic organization and expression of the mouse equilibrative, nitrobenzylthioinosine-sensitive nucleoside transporter 1 (ENT1) gene. Biochem Biophys Res Commun. 2000 Oct 14;277(1):200-8
(Latest) J:213440 Hinton DJ, et al., Aberrant bone density in aging mice lacking the adenosine transporter ENT1. PLoS One. 2014;9(2):e88818
All references(53)
Disease annotation references (1)
Other
accession IDs
MGI:1923527, MGI:2146741

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory