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Slc29a1 Gene Detail
Summary
  • Symbol
    Slc29a1
  • Name
    solute carrier family 29 (nucleoside transporters), member 1
  • Synonyms
    1200014D21Rik, ENT1, NBMPR-sensitive equilibrative nucleoside transporter
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927073
    NCBI Gene: 63959
Location & Maps
more
  • Sequence Map
    Chr17:45585200-45599606 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14407 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC29A1, solute carrier family 29 member 1 (Augustine blood group)
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SLC29A1, solute carrier family 29 member 1 (Augustine blood group)
    Orthology source: HomoloGene
  • Synonyms
    ENT1
  • Links
    NCBI Gene ID: 2030
    neXtProt AC: NX_Q99808

  • Chr Location
    6p21.1; chr6:44219505-44234151 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 37985
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: SLC29A1
  • Protein SuperFamily
    ENT
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Slc29a1 mouse models

Human Disease Mouse Models
       Alcohol Dependence   OMIM: 103780 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null allele exhibit a slightly decreased body weight, increased alcohol preference and alcohol consumption, and reduced hypnotic and ataxic responses to ethanol associated with a reduction in adenosine tone.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036637 VEGA Gene Model | MGI Sequence Detail 14407 C57BL/6J ±  kb
transcript OTTMUST00000093940 VEGA | MGI Sequence Detail 2092 Not Applicable  
polypeptide OTTMUSP00000052199 VEGA | MGI Sequence Detail 460 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    43 from dbSNP Build 142
Protein
Information
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  • UniProt
    16 Sequences
  • Protein Ontology
    PR:000015054 equilibrative nucleoside transporter 1
  • InterPro Domains
    IPR002259 Equilibrative nucleoside transporter
    IPR030195 Equilibrative nucleoside transporter 1
    IPR020846 Major facilitator superfamily domain
Molecular
Reagents
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  • All nucleic 21
    Genomic 1
    cDNA 18
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1923527, MGI:2146741
References
more
  • Summaries
    All 52
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 6
    Phenotypes 21
  • Earliest
    J:65172 Choi DS, et al., Genomic organization and expression of the mouse equilibrative, nitrobenzylthioinosine-sensitive nucleoside transporter 1 (ENT1) gene. Biochem Biophys Res Commun. 2000 Oct 14;277(1):200-8
  • Latest
    J:226281 Kim T, et al., Disrupted sleep-wake regulation in type 1 equilibrative nucleoside transporter knockout mice. Neuroscience. 2015 Sep 10;303:211-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory