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Cables1 Gene Detail
Summary
  • Symbol
    Cables1
  • Name
    CDK5 and Abl enzyme substrate 1
  • Synonyms
    ik3-1, interactor-1 with cdk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927065
    NCBI Gene: 63955
  • Gene Overview
    MyGene.info: CABLES1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:11839274-11945627 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 5.88 cM, cytoband A2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    750 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927065
protein coding gene Chr18:11839220-11945630 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024154
protein coding gene Chr18:8968529-9083868 (+)
A/J MGP_AJ_G0024116
protein coding gene Chr18:8840843-8946905 (+)
AKR/J MGP_AKRJ_G0024083
protein coding gene Chr18:9097404-9202969 (+)
BALB/cJ MGP_BALBcJ_G0024115
protein coding gene Chr18:8785079-8890178 (+)
C3H/HeJ MGP_C3HHeJ_G0023882
protein coding gene Chr18:8979688-9092945 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024560
protein coding gene Chr18:9455774-9564721 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021999
protein coding gene Chr18:8438952-8548195 (+)
CAST/EiJ MGP_CASTEiJ_G0023359
protein coding gene Chr18:8842259-8986722 (+)
CBA/J MGP_CBAJ_G0023854
protein coding gene Chr18:9578245-9690186 (+)
DBA/2J MGP_DBA2J_G0023983
protein coding gene Chr18:8684640-8791122 (+)
FVB/NJ MGP_FVBNJ_G0023948
protein coding gene Chr18:8545160-8652874 (+)
LP/J MGP_LPJ_G0024066
protein coding gene Chr18:9067569-9180520 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023977
protein coding gene Chr18:9761770-9878324 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024606
protein coding gene Chr18:8874190-8985268 (+)
PWK/PhJ MGP_PWKPhJ_G0023105
protein coding gene Chr18:8746477-8887936 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022914
protein coding gene Chr18:9130381-9268484 (+)
WSB/EiJ MGP_WSBEiJ_G0023425
protein coding gene Chr18:8872763-8983594 (+)



Homology
more
  • Human Ortholog
    CABLES1, Cdk5 and Abl enzyme substrate 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CABLES1, Cdk5 and Abl enzyme substrate 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CABL1, CABLES, HsT2563, IK3-1
  • Links
    NCBI Gene ID: 91768
    neXtProt AC: NX_Q8TDN4
    UniProt: Q8TDN4

  • Chr Location
    18q11.2; chr18:23134564-23260470 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null females exhibited reduced fertility and uterine hyperplasia. With chronic exposure to estrogen, homozygous females develop endometrial adenocarcinoma.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 63955 NCBI Gene Model | MGI Sequence Detail 106354 C57BL/6J ±  kb
    transcript NM_001146287 RefSeq | MGI Sequence Detail 3343 C57BL/6  
    polypeptide Q9ESJ1 UniProt | EBI | MGI Sequence Detail 568 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 28
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:63117 Zukerberg LR, et al., Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Neuron. 2000 Jun;26(3):633-46
    • Latest
      J:206297 Mizuno S, et al., Truncated Cables1 causes agenesis of the corpus callosum in mice. Lab Invest. 2014 Mar;94(3):321-30

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory