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Hsd17b12
Gene Detail
 Symbol
Name
ID
Hsd17b12
hydroxysteroid (17-beta) dehydrogenase 12
MGI:1926967
Synonyms 2610510O05Rik, keratoadhesin, keratonectin, KIK-I
Feature Type protein coding gene
Genetic Map
Chromosome 2
51.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:94032689-94157964 bp, - strand
From VEGA annotation of GRCm38

  125276 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:95094  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: 11-beta-HSD1
Gene Tree: Hsd17b12

Human
homologs
Human Homolog HSD17B12, hydroxysteroid (17-beta) dehydrogenase 12
NCBI Gene ID 51144
neXtProt AC  NX_Q53GQ0
Human Synonyms  KAR, SDR12C1
Human Chr (Location)  11p11.2; chr11:43680593-43856619 (+)  GRCh38
Alleles
and
phenotypes
All alleles(60) : Gene trapped(58) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit die around E8.5 with abnormal embryonic and extraembryonic tissue development. ES cells heterozygous for this allele exhibit reduced arachidonic acid levels.
 
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process extracellular matrix organization, lipid metabolic process, ...
Component endoplasmic reticulum, extracellular matrix, ...
Function 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity, 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (128)    Tissues (117)    Images (19)
Theiler Stages: 11, 13, 15, 21, 22, 24, 25, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 101
In situ reporter (knock in) 24
RT-PCR 2
cDNA source data(160)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(163) cDNA(161) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000015008 (Evidence)
Ensembl Gene ModelENSMUSG00000027195 (Evidence)
Entrez Gene56348 (Evidence)
UniGene22505
DFCITC1572120, TC1593142, TC1596883
DoTSDT.40144124, DT.535218, DT.97408878
EC1.3.1.-, 1.1.1.62
Consensus CDS ProjectCCDS16458.1
International Mouse Knockout Project StatusHsd17b12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015008 VEGA Gene Model | MGI Sequence Detail 125276 C57BL/6J ±  kb
transcript OTTMUST00000035665 VEGA | MGI Sequence Detail 1902 Not Applicable 
polypeptide OTTMUSP00000015984 VEGA | MGI Sequence Detail 312 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(578 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000008776 estradiol 17-beta-dehydrogenase 12
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(47)
Other
accession IDs
MGI:1923794, MGI:2138848

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory