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Eif3c Gene Detail
Summary
  • Symbol
    Eif3c
  • Name
    eukaryotic translation initiation factor 3, subunit C
  • Synonyms
    110kDa, 3230401O13Rik, Eif3s8, NIPIL(A3), Xs, Xsl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926966
    NCBI Gene: 56347
  • Gene Overview
    MyGene.info: EIF3C
Location & Maps
more
  • Sequence Map
    Chr7:126546455-126566411 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19957 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.14 cM, cytoband F4
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    EIF3C, eukaryotic translation initiation factor 3 subunit C
  • Vertebrate Orthologs
    8
  • Human Ortholog
    EIF3C, eukaryotic translation initiation factor 3 subunit C
    Orthology source: HomoloGene
  • Synonyms
    EIF3CL, eIF3-p110, EIF3S8
  • Links
    NCBI Gene ID: 8663
    neXtProt AC: NX_Q99613

  • Chr Location
    16p11.2; chr16:28688558-28735730 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (ENU)
    1
  • Gene trapped
    13
  • Spontaneous
    2
  • Targeted
    2
  • Incidental Mutations
Mutations in this gene result in a range of abnormal limb development, including polydactyly, and white coat spotting.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042475 VEGA Gene Model | MGI Sequence Detail 19957 C57BL/6J ±  kb
transcript OTTMUST00000111980 VEGA | MGI Sequence Detail 3383 Not Applicable  
polypeptide OTTMUSP00000062831 VEGA | MGI Sequence Detail 911 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    221 from dbSNP Build 142
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000007288 eukaryotic translation initiation factor 3 subunit C
  • InterPro Domains
    IPR027516 Eukaryotic translation initiation factor 3 subunit C
    IPR008905 Eukaryotic translation initiation factor 3 subunit C, N-terminal domain
    IPR000717 Proteasome component (PCI) domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 16
    cDNA 16

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-15834, MGI:1913935, MGI:3609033, MGI:99138
References
more
  • Summaries
    All 47
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:14234 Lyon MF, et al., Extra-toes spotting, a new polydactyly mutation. Mouse News Lett. 1989;83:158-159
  • Latest
    J:204915 Zeng L, et al., The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. J Biol Chem. 2013 Oct 18;288(42):30087-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory