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Eif3c Gene Detail
Summary
  • Symbol
    Eif3c
  • Name
    eukaryotic translation initiation factor 3, subunit C
  • Synonyms
    110kDa, 3230401O13Rik, Eif3s8, NIPIL(A3), Xs, Xsl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926966
    NCBI Gene: 56347
  • Gene Overview
    MyGene.info: EIF3C
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126546911-126566366 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.14 cM, cytoband F4
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    211 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926966
protein coding gene Chr7:126546455-126566411 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032985
protein coding gene Chr7:130825864-130845904 (-)
A/J MGP_AJ_G0032968
protein coding gene Chr7:127367964-127387839 (-)
AKR/J MGP_AKRJ_G0032900
protein coding gene Chr7:130588858-130608684 (-)
BALB/cJ MGP_BALBcJ_G0032973
protein coding gene Chr7:127024960-127044959 (-)
C3H/HeJ MGP_C3HHeJ_G0032683
protein coding gene Chr7:130517188-130538517 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033479
protein coding gene Chr7:135916761-135938205 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030451
protein coding gene Chr7:128557507-128577324 (-)
CAST/EiJ MGP_CASTEiJ_G0032011
protein coding gene Chr7:122303355-122327845 (-)
CBA/J MGP_CBAJ_G0032656
protein coding gene Chr7:140490444-140510331 (-)
DBA/2J MGP_DBA2J_G0032808
protein coding gene Chr7:125343299-125363204 (-)
FVB/NJ MGP_FVBNJ_G0032761
protein coding gene Chr7:125192373-125212869 (-)
LP/J MGP_LPJ_G0032902
protein coding gene Chr7:132292342-132313416 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032793
protein coding gene Chr7:141678634-141698443 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033498
protein coding gene Chr7:129606271-129626178 (-)
PWK/PhJ MGP_PWKPhJ_G0031719
protein coding gene Chr7:118328420-118350023 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031565
protein coding gene Chr7:116428324-116452165 (-)
WSB/EiJ MGP_WSBEiJ_G0032124
protein coding gene Chr7:130571567-130591449 (-)



Homology
more
  • Human Ortholog
    EIF3C, eukaryotic translation initiation factor 3 subunit C
  • Vertebrate Orthologs
    8
  • Human Ortholog
    EIF3C, eukaryotic translation initiation factor 3 subunit C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EIF3CL, eIF3-p110, EIF3S8
  • Links
    NCBI Gene ID: 8663
    neXtProt AC: NX_Q99613
    UniProt: Q99613

  • Chr Location
    16p11.2; chr16:28688558-28735730 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this gene result in a range of abnormal limb development, including polydactyly, and white coat spotting.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56347 NCBI Gene Model | MGI Sequence Detail 19456 C57BL/6J ±  kb
    transcript NM_146200 RefSeq | MGI Sequence Detail 2896 Not Specified  
    polypeptide Q8R1B4 UniProt | EBI | MGI Sequence Detail 911 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000007288 eukaryotic translation initiation factor 3 subunit C
    • InterPro Domains
      IPR027516 Eukaryotic translation initiation factor 3 subunit C
      IPR008905 Eukaryotic translation initiation factor 3 subunit C, N-terminal domain
      IPR000717 Proteasome component (PCI) domain
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15834, MGI:1913935, MGI:3609033, MGI:99138
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:204915 Zeng L, et al., The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. J Biol Chem. 2013 Oct 18;288(42):30087-93

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory