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Cyb5a Gene Detail
Summary
  • Symbol
    Cyb5a
  • Name
    cytochrome b5 type A (microsomal)
  • Synonyms
    0610009N12Rik, Cyb5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926952
    NCBI Gene: 109672
Location & Maps
more
  • Sequence Map
    Chr18:84851338-84880401 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29064 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 57.53 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CYB5A, cytochrome b5 type A
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CYB5A, cytochrome b5 type A
    Orthology source: HomoloGene
  • Synonyms
    CYB5, MCB5
  • Links
    NCBI Gene ID: 1528
    neXtProt AC: NX_P00167

  • Chr Location
    18q23; chr18:74253292-74292016 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CYB5A associations

Human Disease Mouse Models
       Methemoglobinemia Type IV   OMIM: 250790
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Gene trapped
    12
  • Targeted
    3
  • Transposon induced
    1
  • Genomic Mutations
    1 involving Cyb5a
  • Incidental Mutations
Mice homozygous for a conditional allele exhibit abnormal pharmacokinetics of xenobiotics following cre-mediated recombination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030922 VEGA Gene Model | MGI Sequence Detail 29064 C57BL/6J ±  kb
transcript OTTMUST00000076513 VEGA | MGI Sequence Detail 1363 Not Applicable  
polypeptide OTTMUSP00000040293 VEGA | MGI Sequence Detail 134 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    245 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006078 cytochrome b5
  • InterPro Domains
    IPR018506 Cytochrome b5, heme-binding site
    IPR001199 Cytochrome b5-like heme/steroid binding domain
Molecular
Reagents
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  • All nucleic 186
    cDNA 185
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:1914096
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:65999 Hanlon MR, et al., In vitro membrane-inserted conformation of the cytochrome b5 tail. Biochem J. 2000 Nov 15;352 Pt 1:117-24
  • Latest
    J:201924 Plitzko B, et al., The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in human cells. J Biol Chem. 2013 Jul 12;288(28):20228-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory