Cyb5
Gene Detail

Symbol Name ID

Cyb5 cytochrome b-5 MGI:1926952

Synonyms

0610009N12Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 18

57.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr18:84851338-84880401 bp, + strand From VEGA annotation of GRCm38   29064 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41475  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cytochrome b5
Gene Tree: Cyb5

Human homologs

Human Homolog		CYB5A, cytochrome b5 type A (microsomal)
NCBI Gene ID		1528
neXtProt AC		NX_P00167
Human Synonyms		CYB5, MCB5
Human Chr (Location)		18q23; chr18:71920527-71959251 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CYB5A

Alleles and phenotypes

All alleles(15) : Targeted(3) Gene trapped(12)
 

Mice homozygous for a conditional allele exhibit abnormal pharmacokinetics of xenobiotics following cre-mediated recombination.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	electron transport chain, fatty acid metabolic process, ...
Component	endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function	enzyme binding, heme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (7)    Tissues (7)    Images (1)
Theiler Stages: 3, 4, 5

Assay Type	Results
RT-PCR	7

cDNA source data(186)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(187) cDNA(186) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000030922 (Evidence)
Ensembl Gene Model	ENSMUSG00000024646 (Evidence)
Entrez Gene	109672 (Evidence)
UniGene	31018
DFCI	TC1572919
DoTS	DT.87078963
NIA Mouse Gene Index	U018973
Consensus CDS Project	CCDS29385.1
International Mouse Knockout Project Status	Cyb5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030922	VEGA Gene Model | MGI Sequence Detail	29064	C57BL/6J
transcript	OTTMUST00000076513	VEGA | MGI Sequence Detail	1363	Not Applicable
polypeptide	OTTMUSP00000040293	VEGA | MGI Sequence Detail	134	Not Applicable

All sequences(36) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(207 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018506	Cytochrome b5, heme-binding site
InterPro	IPR001199	Cytochrome b5-like heme/steroid binding domain
Protein Ontology	PR:000006078	cytochrome b5

References

(Earliest) J:65999 Hanlon MR, et al., In vitro membrane-inserted conformation of the cytochrome b5 tail. Biochem J. 2000 Nov 15;352 Pt 1:117-24
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)

Other accession IDs

MGI:1914096