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Calcrl Gene Detail
Summary
  • Symbol
    Calcrl
  • Name
    calcitonin receptor-like
  • Synonyms
    CRLR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926944
    NCBI Gene: 54598
  • Gene Overview
    MyGene.info: CALCRL
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:84330626-84425411 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 49.38 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    646 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926944
protein coding gene Chr2:84330626-84425426 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025898
protein coding gene Chr2:84993751-85103173 (-)
A/J MGP_AJ_G0025872
protein coding gene Chr2:81718907-81816192 (-)
AKR/J MGP_AKRJ_G0025842
protein coding gene Chr2:83826403-83923917 (-)
BALB/cJ MGP_BALBcJ_G0025869
protein coding gene Chr2:81851226-81948806 (-)
C3H/HeJ MGP_C3HHeJ_G0025628
protein coding gene Chr2:84072194-84171846 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026315
protein coding gene Chr2:87629357-87741227 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023717
protein coding gene Chr2:78557724-78651427 (-)
CAST/EiJ MGP_CASTEiJ_G0025089
protein coding gene Chr2:84572115-84675584 (-)
CBA/J MGP_CBAJ_G0025609
protein coding gene Chr2:90773866-90889642 (-)
DBA/2J MGP_DBA2J_G0025740
protein coding gene Chr2:81263027-81360636 (-)
FVB/NJ MGP_FVBNJ_G0025703
protein coding gene Chr2:80498472-80601453 (-)
LP/J MGP_LPJ_G0025828
protein coding gene Chr2:84808757-84906912 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0026371
protein coding gene Chr2:84041627-84144901 (-)
PWK/PhJ MGP_PWKPhJ_G0024833
protein coding gene Chr2:81083089-81185034 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024637
protein coding gene Chr2:84186094-84294264 (-)
WSB/EiJ MGP_WSBEiJ_G0025159
protein coding gene Chr2:84717352-84820660 (-)



Homology
more
  • Human Ortholog
    CALCRL, calcitonin receptor like receptor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CALCRL, calcitonin receptor like receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGRPR, CRLR
  • Links
    NCBI Gene ID: 10203
    neXtProt AC: NX_Q16602
    UniProt: Q16602

  • Chr Location
    2q32.1; chr2:187341963-187448307 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    2 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality between E13.5-E14.5, hydrops fetalis and cardiovascular defects such as thin vascular smooth muscle walls and small, disorganized hearts resulting from a decrease in cell proliferation and an increasein apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059588 Ensembl Gene Model | MGI Sequence Detail 94786 C57BL/6J ±  kb
    transcript ENSMUST00000074262 Ensembl | MGI Sequence Detail 4882 Not Applicable  
    polypeptide ENSMUSP00000073875 Ensembl | MGI Sequence Detail 463 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004973 calcitonin gene-related peptide type 1 receptor
    • InterPro Domains
      IPR003289 GPCR, family 2, calcitonin gene-related peptide, type 1 receptor
      IPR003287 GPCR, family 2, calcitonin receptor family
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR017981 GPCR, family 2-like
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2139246
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:30368 Bidegain M, et al., Calcitonin gene-related peptide (CGRP) in the developing mouse limb. Endocr Res. 1995 Nov;21(4):743-55
    • Latest
      J:245423 Kadmiel M, et al., Loss of receptor activity-modifying protein 2 in mice causes placental dysfunction and alters PTH1R regulation. PLoS One. 2017;12(7):e0181597

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory