About   Help   FAQ
Calcrl
Gene Detail
 Symbol
Name
ID
Calcrl
calcitonin receptor-like
MGI:1926944
Synonyms CRLR
Feature Type protein coding gene
Genetic Map
Chromosome 2
49.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:84330626-84425411 bp, - strand
From VEGA annotation of GRCm38

  94786 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21179  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Calcrl

Human
homologs
Human Homolog CALCRL, calcitonin receptor-like
NCBI Gene ID 10203
neXtProt AC  NX_Q16602
Human Synonyms  CGRPR, CRLR
Human Chr (Location)  2q32.1; chr2:187341963-187448294 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving Calcrl (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in lethality between E13.5-E14.5, hydrops fetalis and cardiovascular defects such as thin vascular smooth muscle walls and small, disorganized hearts resulting from a decrease in cell proliferation and an increase in apoptosis.
 
Human Diseases Modeled Using Mouse Calcrl (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Calcrl interacts with 326 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process adenylate cyclase-activating G-protein coupled receptor signaling pathway, angiogenesis, ...
Component endoplasmic reticulum, endosome, ...
Function adrenomedullin receptor activity, calcitonin gene-related polypeptide receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 19
Assay TypeResults
RNA in situ 1
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000013406 (Evidence)
Ensembl Gene ModelENSMUSG00000059588 (Evidence)
Entrez Gene54598 (Evidence)
UniGene75467
DFCITC1583851, TC1594954, TC1684846
DoTSDT.87072251, DT.94170530
NIA Mouse Gene IndexU022806
Consensus CDS ProjectCCDS16184.1
International Mouse Knockout Project StatusCalcrl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013406 VEGA Gene Model | MGI Sequence Detail 94786 C57BL/6J ±  kb
transcript OTTMUST00000032380 VEGA | MGI Sequence Detail 4882 Not Applicable 
polypeptide OTTMUSP00000014383 VEGA | MGI Sequence Detail 463 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(7) UniProt(2)
Polymorphisms SNPs within 2kb(659 from dbSNP Build 137)    SNPs within 2kb including multiple locations(663)
Protein-related
information
ResourceIDDescription
InterPro IPR003289 GPCR, family 2, calcitonin gene-related peptide, type 1 receptor
InterPro IPR003287 GPCR, family 2, calcitonin receptor family
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
Protein Ontology PR:000004973 calcitonin gene-related peptide type 1 receptor
References (Earliest) J:30368 Bidegain M, et al., Calcitonin gene-related peptide (CGRP) in the developing mouse limb. Endocr Res. 1995 Nov;21(4):743-55
(Latest) J:201446 Li M, et al., Fetal-derived adrenomedullin mediates the innate immune milieu of the placenta. J Clin Invest. 2013 Jun 3;123(6):2408-20
All references(38)
Disease annotation references (1)
Other
accession IDs
MGI:2139246

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory