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Calcrl Gene Detail
Summary
  • Symbol
    Calcrl
  • Name
    calcitonin receptor-like
  • Synonyms
    CRLR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926944
    NCBI Gene: 54598
  • Gene Overview
    MyGene.info: CALCRL
Location & Maps
more
  • Sequence Map
    Chr2:84330626-84425411 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      94786 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 49.38 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CALCRL, calcitonin receptor like receptor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CALCRL, calcitonin receptor like receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CGRPR, CRLR
  • Links
    NCBI Gene ID: 10203
    neXtProt AC: NX_Q16602

  • Chr Location
    2q32.1; chr2:187341963-187448294 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Calcrl mouse models

Human Disease Mouse Models
       Hydrops Fetalis, Nonimmune; NIHF   OMIM: 236750 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    2 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Targeted
    6
  • Genomic Mutations
    3 involving Calcrl
  • Incidental Mutations
Homozygous mutation of this gene results in lethality between E13.5-E14.5, hydrops fetalis and cardiovascular defects such as thin vascular smooth muscle walls and small, disorganized hearts resulting from a decrease in cell proliferation and an increasein apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013406 VEGA Gene Model | MGI Sequence Detail 94786 C57BL/6J ±  kb
transcript OTTMUST00000032380 VEGA | MGI Sequence Detail 4882 Not Applicable  
polypeptide OTTMUSP00000014383 VEGA | MGI Sequence Detail 463 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    646 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000004973 calcitonin gene-related peptide type 1 receptor
  • InterPro Domains
    IPR003289 GPCR, family 2, calcitonin gene-related peptide, type 1 receptor
    IPR003287 GPCR, family 2, calcitonin receptor family
    IPR001879 GPCR, family 2, extracellular hormone receptor domain
    IPR017981 GPCR, family 2-like
    IPR000832 GPCR, family 2, secretin-like
    IPR017983 GPCR, family 2, secretin-like, conserved site
Molecular
Reagents
less
  • All nucleic 24
    cDNA 24

    Microarray probesets 5
Other
Accession IDs
less
MGI:2139246
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:30368 Bidegain M, et al., Calcitonin gene-related peptide (CGRP) in the developing mouse limb. Endocr Res. 1995 Nov;21(4):743-55
  • Latest
    J:218915 Li M, et al., Deficiency of RAMP1 attenuates antigen-induced airway hyperresponsiveness in mice. PLoS One. 2014;9(7):e102356

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory