Calcrl
Gene Detail

Symbol Name ID

Calcrl calcitonin receptor-like MGI:1926944

Synonyms

CRLR

Feature Type

protein coding gene

Genetic Map

Chromosome 2

49.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:84330626-84425411 bp, - strand From VEGA annotation of GRCm38   94786 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21179  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Calcrl

Human homologs

Human Homolog		CALCRL, calcitonin receptor-like
NCBI Gene ID		10203
neXtProt AC		NX_Q16602
Human Synonyms		CGRPR, CRLR
Human Chr (Location)		2q32.1; chr2:188207846-188313021 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous mutation of this gene results in lethality between E13.5-E14.5, hydrops fetalis and cardiovascular defects such as thin vascular smooth muscle walls and small, disorganized hearts resulting from a decrease in cell proliferation and an increase in apoptosis.

 
Human Diseases Modeled Using Mouse Calcrl (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	adenylate cyclase-activating G-protein coupled receptor signaling pathway, angiogenesis, ...
Component	endoplasmic reticulum, endosome, ...
Function	adrenomedullin receptor activity, calcitonin gene-related polypeptide receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 19

Assay Type	Results
RNA in situ	1

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(23)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000013406 (Evidence)
Ensembl Gene Model	ENSMUSG00000059588 (Evidence)
Entrez Gene	54598 (Evidence)
UniGene	75467
DFCI	TC1583851, TC1594954, TC1684846
DoTS	DT.87072251, DT.94170530
NIA Mouse Gene Index	U022806
Consensus CDS Project	CCDS16184.1
International Mouse Knockout Project Status	Calcrl

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013406	VEGA Gene Model | MGI Sequence Detail	94786	C57BL/6J
transcript	OTTMUST00000032380	VEGA | MGI Sequence Detail	4882	Not Applicable
polypeptide	OTTMUSP00000014383	VEGA | MGI Sequence Detail	463	Not Applicable

All sequences(31) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(159 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003289	GPCR, family 2, calcitonin gene-related peptide, type 1 receptor
InterPro	IPR003287	GPCR, family 2, calcitonin receptor family
InterPro	IPR001879	GPCR, family 2, extracellular hormone receptor domain
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR000832	GPCR, family 2, secretin-like
InterPro	IPR017983	GPCR, family 2, secretin-like, conserved site
Protein Ontology	PR:000004973	calcitonin gene-related peptide type 1 receptor

References

(Earliest) J:30368 Bidegain M, et al., Calcitonin gene-related peptide (CGRP) in the developing mouse limb. Endocr Res. 1995 Nov;21(4):743-55
(Latest) J:191789 Hoopes SL, et al., Characteristics of multi-organ lymphangiectasia resulting from temporal deletion of calcitonin receptor-like receptor in adult mice. PLoS One. 2012;7(9):e45261
All references(37)

Other accession IDs

MGI:2139246