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Atp12a
Gene Detail
 Symbol
Name
ID
Atp12a
ATPase, H+/K+ transporting, nongastric, alpha polypeptide
MGI:1926943
Synonyms Atp1al1, ATPase H+K+-transporting, alpha 2, cHKA, HKalpha2
Feature Type protein coding gene
Genetic Map
Chromosome 14
28.19 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:56365068-56388551 bp, + strand
From NCBI annotation of GRCm38

  23484 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68197  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp12a

Human
homologs
Human Homolog ATP12A, ATPase, H+/K+ transporting, nongastric, alpha polypeptide
NCBI Gene ID 479
neXtProt AC  NX_P54707
Human Synonyms  ATP1AL1
Human Chr (Location)  13q12.12; chr13:24680411-24711785 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in increased potassium excretion. When placed on a potassium-free diet, mutant animals display greater weight loss and slightly increased kidney weight compared to wild-type.
 
Interactions
Atp12a interacts with 133 markers (Mir23a, Mir23b, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process ATP biosynthetic process, cation transport, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function ATP binding, cation-transporting ATPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) Genomic(6) cDNA(6)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000022229 (Evidence)
Entrez Gene192113 (Evidence)
UniGene273271
DFCITC1586560
DoTSDT.40179701
NIA Mouse Gene IndexU015677
EC3.6.3.10
Consensus CDS ProjectCCDS27148.1
International Mouse Knockout Project StatusAtp12a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 192113 NCBI Gene Model | MGI Sequence Detail 23484 C57BL/6J ±  kb
transcript NM_138652 RefSeq | MGI Sequence Detail 3954 Not Specified 
polypeptide Q9Z1W8 UniProt | EBI | MGI Sequence Detail 1035 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR006068 Cation-transporting P-type ATPase, C-terminal
InterPro IPR004014 Cation-transporting P-type ATPase, N-terminal
InterPro IPR023214 HAD-like domain
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
InterPro IPR023298 P-type ATPase, transmembrane domain
InterPro IPR005775 Sodium/potassium-transporting P-type ATPase, subfamily IIC
Protein Ontology PR:000004434 potassium-transporting ATPase alpha chain 2
Graphical View of Protein Domain Structure
References (Earliest) J:75632 Ono S, et al., Role of H(+)-K(+)-ATPase in pHi regulation in inner medullary collecting duct cells in culture. Am J Physiol. 1996 May;270(5 Pt 2):F852-61
(Latest) J:185882 Greenlee MM, et al., Mineralocorticoids stimulate the activity and expression of renal H+,K+-ATPases. J Am Soc Nephrol. 2011 Jan;22(1):49-58
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory