About   Help   FAQ
Bcmo1
Gene Detail
 Symbol
Name
ID
Bcmo1
beta-carotene 15,15'-monooxygenase
MGI:1926923
Synonyms Bcdo, Bcdo1, beta-CD, betaCMOOX, Cmoi
Feature Type protein coding gene
Genetic Map
Chromosome 8
63.61 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:117095854-117133720 bp, + strand
From VEGA annotation of GRCm38

  37867 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41172  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: carotenoid oxygenase
Gene Tree: Bcmo1

Human
homologs
Human Homolog BCMO1, beta-carotene 15,15'-monooxygenase 1
NCBI Gene ID 53630
neXtProt AC  NX_Q9HAY6
Human Synonyms  BCDO, BCDO1, BCMO, BCO, BCO1
Human Chr (Location)  16q23.2; chr16:81238691-81291142 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human BCMO1
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display fatty livers, elevated serum free fatty acid levels, increased susceptibility to diet-induced obesity, and impaired conversion of beta-carotene to vitamin A.
 
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process oxidation-reduction process, retinoid metabolic process
Function beta-carotene 15,15'-monooxygenase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (151)    Tissues (124)    Images (15)
Theiler Stages: 9, 10, 11, 13, 15, 17, 18, 20, 21, 22, 23, 28
Assay TypeResults
RNA in situ 94
Northern blot 16
Western blot 17
RT-PCR 24
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000023047 (Evidence)
Ensembl Gene ModelENSMUSG00000031845 (Evidence)
Entrez Gene63857 (Evidence)
UniGene174133
DFCITC1587154
DoTSDT.55108876
NIA Mouse Gene IndexU009863
EC1.14.99.36
Consensus CDS ProjectCCDS22697.1, CCDS52679.1
International Mouse Knockout Project StatusBcmo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023047 VEGA Gene Model | MGI Sequence Detail 37867 C57BL/6J ±  kb
transcript OTTMUST00000055544 VEGA | MGI Sequence Detail 2338 Not Applicable 
polypeptide OTTMUSP00000026605 VEGA | MGI Sequence Detail 566 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(148 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004294 Carotenoid oxygenase
Protein Ontology PR:000004707 beta,beta-carotene 15,15'-monooxygenase
References (Earliest) J:66309 Wyss A, et al., Cloning and expression of beta,beta-carotene 15,15'-dioxygenase. Biochem Biophys Res Commun. 2000 May 10;271(2):334-6
(Latest) J:204979 Amengual J, et al., Two carotenoid oxygenases contribute to mammalian provitamin A metabolism. J Biol Chem. 2013 Nov 22;288(47):34081-96
All references(50)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory