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Bco1 Gene Detail
Summary
  • Symbol
    Bco1
  • Name
    beta-carotene oxygenase 1
  • Synonyms
    Bcdo, Bcdo1, Bcmo1, beta-CD, betaCMOOX, Cmoi
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926923
    NCBI Gene: 63857
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:117095854-117133720 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 63.61 cM, cytoband E1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    148 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926923
protein coding gene Chr8:117095851-117133720 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034171
protein coding gene Chr8:120227387-120270084 (+)
A/J MGP_AJ_G0034151
protein coding gene Chr8:115335409-115375185 (+)
AKR/J MGP_AKRJ_G0034078
protein coding gene Chr8:118692678-118732192 (+)
BALB/cJ MGP_BALBcJ_G0034145
protein coding gene Chr8:115533406-115571874 (+)
C3H/HeJ MGP_C3HHeJ_G0033856
protein coding gene Chr8:119418238-119459220 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034665
protein coding gene Chr8:124315633-124355565 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031607
protein coding gene Chr8:108261813-108298717 (+)
CAST/EiJ MGP_CASTEiJ_G0033183
protein coding gene Chr8:119243772-119289822 (+)
CBA/J MGP_CBAJ_G0033829
protein coding gene Chr8:128788278-128835522 (+)
DBA/2J MGP_DBA2J_G0033985
protein coding gene Chr8:114561049-114598877 (+)
FVB/NJ MGP_FVBNJ_G0033928
protein coding gene Chr8:113550825-113595035 (+)
LP/J MGP_LPJ_G0034074
protein coding gene Chr8:120358511-120399103 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033975
protein coding gene Chr8:131395362-131439110 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034683
protein coding gene Chr8:118778450-118818431 (+)
PWK/PhJ MGP_PWKPhJ_G0032885
protein coding gene Chr8:114263914-114304594 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032725
protein coding gene Chr8:117476847-117516544 (+)
WSB/EiJ MGP_WSBEiJ_G0033299
protein coding gene Chr8:119491465-119538933 (+)



Homology
more
  • Human Ortholog
    BCO1, beta-carotene oxygenase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BCO1, beta-carotene oxygenase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BCDO, BCDO1, BCMO, BCMO1, BCO
  • Links
    NCBI Gene ID: 53630
    neXtProt AC: NX_Q9HAY6
    UniProt: Q9HAY6

  • Chr Location
    16q23.2; chr16:81238642-81291142 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display fatty livers, elevated serum free fatty acid levels, increased susceptibility to diet-induced obesity, and impaired conversion of beta-carotene to vitamin A.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031845 Ensembl Gene Model | MGI Sequence Detail 37867 C57BL/6J ±  kb
    transcript ENSMUST00000034308 Ensembl | MGI Sequence Detail 2338 Not Applicable  
    polypeptide ENSMUSP00000034308 Ensembl | MGI Sequence Detail 566 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 13
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 25
    • Earliest
      J:66309 Wyss A, et al., Cloning and expression of beta,beta-carotene 15,15'-dioxygenase. Biochem Biophys Res Commun. 2000 May 10;271(2):334-6
    • Latest
      J:265585 Lim JY, et al., Ablation of carotenoid cleavage enzymes (BCO1 and BCO2) induced hepatic steatosis by altering the farnesoid X receptor/miR-34a/sirtuin 1 pathway. Arch Biochem Biophys. 2018 Sep 15;654:1-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory