Bcmo1
Gene Detail

Symbol Name ID

Bcmo1 beta-carotene 15,15'-monooxygenase MGI:1926923

Synonyms

Bcdo, Bcdo1, beta-CD, betaCMOOX, Cmoi

Feature Type

protein coding gene

Genetic Map

Chromosome 8

63.61 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr8:117095854-117133720 bp, + strand From VEGA annotation of GRCm38   37867 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41172  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: carotenoid oxygenase
Gene Tree: Bcmo1

Human homologs

Human Homolog		BCMO1, beta-carotene 15,15'-monooxygenase 1
NCBI Gene ID		53630
neXtProt AC		NX_Q9HAY6
Human Synonyms		BCDO, BCDO1, BCMO, BCO, BCO1
Human Chr (Location)		16q23.2; chr16:81272296-81324747 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human BCMO1

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a null mutation display fatty livers, elevated serum free fatty acid levels, increased susceptibility to diet-induced obesity, and impaired conversion of beta-carotene to vitamin A.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	oxidation-reduction process, retinoid metabolic process
Function	beta-carotene 15,15'-monooxygenase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (151)    Tissues (124)    Images (15)
Theiler Stages: 9, 10, 11, 13, 15, 17, 18, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	94
Northern blot	16
Western blot	17
RT-PCR	24

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000023047 (Evidence)
Ensembl Gene Model	ENSMUSG00000031845 (Evidence)
Entrez Gene	63857 (Evidence)
UniGene	174133
DFCI	TC1587154
DoTS	DT.55108876
NIA Mouse Gene Index	U009863
EC	1.14.99.36
Consensus CDS Project	CCDS22697.1, CCDS52679.1
International Mouse Knockout Project Status	Bcmo1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023047	VEGA Gene Model | MGI Sequence Detail	37867	C57BL/6J
transcript	OTTMUST00000055544	VEGA | MGI Sequence Detail	2338	Not Applicable
polypeptide	OTTMUSP00000026605	VEGA | MGI Sequence Detail	566	Not Applicable

All sequences(33) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(57 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004294	Carotenoid oxygenase
Protein Ontology	PR:000004707	beta,beta-carotene 15,15'-monooxygenase

References

(Earliest) J:66309 Wyss A, et al., Cloning and expression of beta,beta-carotene 15,15'-dioxygenase. Biochem Biophys Res Commun. 2000 May 10;271(2):334-6
(Latest) J:190746 Osuala K, et al., Physiological and genomic consequences of adrenergic deficiency during embryonic/fetal development in mice: impact on retinoic acid metabolism. Physiol Genomics. 2012 Oct 2;44(19):934-47
All references(47)