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Bco1
Gene Detail
Symbol

Name
ID
Bco1
beta-carotene oxygenase 1
MGI:1926923
Synonyms
Bcdo, Bcdo1, Bcmo1, beta-CD, betaCMOOX, Cmoi
Feature Type
protein coding gene
Genetic Map
Chromosome 8
63.61 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:117095854-117133720 bp, + strand
From VEGA annotation of GRCm38

  37867 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41172  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: carotenoid oxygenase
Gene Tree: Bco1

Human
homologs
Human Homolog BCO1, beta-carotene oxygenase 1
NCBI Gene ID 53630
neXtProt AC  NX_Q9HAY6
Human Synonyms  BCDO, BCDO1, BCMO, BCMO1, BCO
Human Chr (Location)  16q23.2; chr16:81238691-81291142 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human BCO1
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display fatty livers, elevated serum free fatty acid levels, increased susceptibility to diet-induced obesity, and impaired conversion of beta-carotene to vitamin A.
 
Interactions
Bco1 interacts with 69 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process oxidation-reduction process, retinoid metabolic process
Function beta-carotene 15,15'-monooxygenase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (151)    Tissues (124)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 16
Western blot 17
RT-PCR 24
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000023047 (Evidence)
Ensembl Gene ModelENSMUSG00000031845 (Evidence)
Entrez Gene63857 (Evidence)
UniGene174133
DFCITC1587154
DoTSDT.55108876
NIA Mouse Gene IndexU009863
EC1.14.99.36
Consensus CDS ProjectCCDS22697.1, CCDS52679.1
International Mouse Knockout Project StatusBco1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023047 VEGA Gene Model | MGI Sequence Detail 37867 C57BL/6J ±  kb
transcript OTTMUST00000055544 VEGA | MGI Sequence Detail 2338 Not Applicable 
polypeptide OTTMUSP00000026605 VEGA | MGI Sequence Detail 566 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(148 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004294 Carotenoid oxygenase
Protein Ontology PR:000004707 beta,beta-carotene 15,15'-monooxygenase
References
(Earliest) J:66309 Wyss A, et al., Cloning and expression of beta,beta-carotene 15,15'-dioxygenase. Biochem Biophys Res Commun. 2000 May 10;271(2):334-6
(Latest) J:210054 Dixon JL, et al., Loss of beta-carotene 15,15'-oxygenase in developing mouse tissues alters esterification of retinol, cholesterol and diacylglycerols. Biochim Biophys Acta. 2014 Jan;1841(1):34-43
All references(51)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory