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Fn3k Gene Detail
Summary
  • Symbol
    Fn3k
  • Name
    fructosamine 3 kinase
  • Synonyms
    2310074G21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926834
    NCBI Gene: 63828
  • Gene Overview
    MyGene.info: FN3K
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:121434913-121450491 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 85.38 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926834
protein coding gene Chr11:121434803-121450491 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019549
protein coding gene Chr11:125983134-125998763 (+)
A/J MGP_AJ_G0019516
protein coding gene Chr11:120341522-120357088 (+)
AKR/J MGP_AKRJ_G0019486
protein coding gene Chr11:123995386-124010960 (+)
BALB/cJ MGP_BALBcJ_G0019491
protein coding gene Chr11:120721157-120736727 (+)
C3H/HeJ MGP_C3HHeJ_G0019297
protein coding gene Chr11:124327112-124342681 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019940
protein coding gene Chr11:129798295-129813845 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017565
protein coding gene Chr11:117330597-117346538 (+)
CAST/EiJ MGP_CASTEiJ_G0018851
protein coding gene Chr11:125812534-125829760 (+)
CBA/J MGP_CBAJ_G0019268
protein coding gene Chr11:134830252-134847946 (+)
DBA/2J MGP_DBA2J_G0019381
protein coding gene Chr11:119729140-119745210 (+)
FVB/NJ MGP_FVBNJ_G0019372
protein coding gene Chr11:119450832-119466687 (+)
LP/J MGP_LPJ_G0019452
protein coding gene Chr11:126255174-126272774 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019405
protein coding gene Chr11:133638482-133654041 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019979
protein coding gene Chr11:124686384-124701961 (+)
PWK/PhJ MGP_PWKPhJ_G0018618
protein coding gene Chr11:121158684-121175555 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018408
protein coding gene Chr11:124367471-124445674 (+)
WSB/EiJ MGP_WSBEiJ_G0018904
protein coding gene Chr11:124648768-124664257 (+)



Homology
more
  • Human Ortholog
    FN3K, fructosamine 3 kinase
  • Vertebrate Orthologs
    6
  • Human Ortholog
    FN3K, fructosamine 3 kinase
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 64122
    neXtProt AC: NX_Q9H479
    UniProt: Q9H479

  • Chr Location
    17q25.3; chr17:82735576-82751197 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele grow and reproduce normally and appear healthy while cellular levels of glycated proteins and free fructoselysine are elevated in several tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025175 Ensembl Gene Model | MGI Sequence Detail 15579 C57BL/6J ±  kb
transcript ENSMUST00000026175 Ensembl | MGI Sequence Detail 1047 Not Applicable  
polypeptide ENSMUSP00000026175 Ensembl | MGI Sequence Detail 309 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 20

    Microarray probesets 6
Other
Accession IDs
less
MGI:1916917
References
more
  • Summaries
    All 28
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:64795 Delpierre G, et al., Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase. Diabetes. 2000 Oct;49(10):1627-34
  • Latest
    J:255175 Dunmore SJ, et al., Evidence That Differences in Fructosamine-3-Kinase Activity May Be Associated With the Glycation Gap in Human Diabetes. Diabetes. 2018 Jan;67(1):131-136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory