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Kcnq4
Gene Detail
Symbol

Name
ID
Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
MGI:1926803
Feature Type
protein coding gene
Genetic Map
Chromosome 4
56.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:120696138-120748612 bp, - strand
From VEGA annotation of GRCm38

  52475 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:78107  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: KCNQ4
Protein SuperFamily: potassium voltage-gated channel, subfamily KQT
Gene Tree: Kcnq4

Human
homologs
KCNQ4, potassium channel, voltage gated KQT-like subfamily Q, member 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9132
neXtProt AC: NX_P56696

Human Synonyms: DFNA2, DFNA2A, KV7.4

Human Chr (Location): 1p34; chr1:40784012-40840452 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KCNQ4

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving Kcnq4 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice that are either homozygous for a knock-out allele or homozygous for a dominant negative knock-in allele exhibit a slowly progressive hearing loss due to chronic depolarization and subsequent degeneration of cochlear outer hair cells.
 
Interactions
Kcnq4 interacts with 243 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process inner ear morphogenesis, ion transport, ...
Component cytoplasm, integral component of membrane, ...
Function delayed rectifier potassium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (12)    Tissues (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 12
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase kcnq4    NEW 
Molecular
reagents
All nucleic(13) cDNA(10) Primer pair(3)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000008856 (Evidence)
Ensembl Gene Model ENSMUSG00000028631 (Evidence)
Entrez Gene 60613 (Evidence)
UniGene 249977
DFCI TC1609558, TC1601535
DoTS DT.91391425, DT.101215805
NIA Mouse Gene Index U025479
Consensus CDS Project CCDS38865.1
International Mouse Phenotyping Consortium Status Kcnq4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008856 VEGA Gene Model | MGI Sequence Detail 52475 C57BL/6J ±  kb
transcript OTTMUST00000020143 VEGA | MGI Sequence Detail 3919 Not Applicable 
polypeptide OTTMUSP00000009240 VEGA | MGI Sequence Detail 696 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(326 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
InterPro IPR003937 Potassium channel, voltage dependent, KCNQ
InterPro IPR015573 Potassium channel, voltage dependent, KCNQ4
InterPro IPR013821 Potassium channel, voltage dependent, KCNQ, C-terminal
InterPro IPR003091 Voltage-dependent potassium channel
Protein Ontology PR:000000731 voltage-gated potassium channel subunit KCNQ4
References
(Earliest) J:65445 Beisel KW, et al., Longitudinal gradients of KCNQ4 expression in spiral ganglion and cochlear hair cells correlate with progressive hearing loss in DFNA2(1). Brain Res Mol Brain Res. 2000 Oct 20;82(1-2):137-49
(Latest) J:212089 Iannotti FA, et al., The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):E2472-81
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory