Kcnq4
Gene Detail

Symbol Name ID

Kcnq4 potassium voltage-gated channel, subfamily Q, member 4 MGI:1926803

Feature Type

protein coding gene

Genetic Map

Chromosome 4

56.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:120696138-120748612 bp, - strand From VEGA annotation of GRCm38   52475 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:78107  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: potassium voltage-gated channel, subfamily KQT
Gene Tree: Kcnq4

Human homologs

Human Homolog		KCNQ4, potassium voltage-gated channel, KQT-like subfamily, member 4
NCBI Gene ID		9132
neXtProt AC		NX_P56696
Human Synonyms		DFNA2, DFNA2A, KV7.4
Human Chr (Location)		1p34; chr1:41249684-41306124 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human KCNQ4

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice that are either homozygous for a knock-out allele or homozygous for a dominant negative knock-in allele exhibit a slowly progressive hearing loss due to chronic depolarization and subsequent degeneration of cochlear outer hair cells.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	inner ear morphogenesis, ion transport, ...
Component	cytoplasm, integral to membrane, ...
Function	delayed rectifier potassium channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (12)    Tissues (7)   
Theiler Stages: 23, 24, 25, 26, 28

Assay Type	Results
RT-PCR	12

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(10) Primer pair(3)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000008856 (Evidence)
Ensembl Gene Model	ENSMUSG00000028631 (Evidence)
Entrez Gene	60613 (Evidence)
UniGene	249977
DFCI	TC1601535, TC1609558
DoTS	DT.101215805, DT.91391425
NIA Mouse Gene Index	U025479
Consensus CDS Project	CCDS38865.1
International Mouse Knockout Project Status	Kcnq4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008856	VEGA Gene Model | MGI Sequence Detail	52475	C57BL/6J
transcript	OTTMUST00000020143	VEGA | MGI Sequence Detail	3919	Not Applicable
polypeptide	OTTMUSP00000009240	VEGA | MGI Sequence Detail	696	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(296 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005821	Ion transport domain
InterPro	IPR003937	Potassium channel, voltage dependent, KCNQ
InterPro	IPR015573	Potassium channel, voltage dependent, KCNQ4
InterPro	IPR013821	Potassium channel, voltage dependent, KCNQ, C-terminal
InterPro	IPR003091	Voltage-dependent potassium channel
Protein Ontology	PR:000000731	voltage-gated potassium channel subunit KCNQ4

References

(Earliest) J:65445 Beisel KW, et al., Longitudinal gradients of KCNQ4 expression in spiral ganglion and cochlear hair cells correlate with progressive hearing loss in DFNA2(1). Brain Res Mol Brain Res. 2000 Oct 20;82(1-2):137-49
(Latest) J:181639 Wende H, et al., The transcription factor c-Maf controls touch receptor development and function. Science. 2012 Mar 16;335(6074):1373-6
All references(34)