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Trp53inp1 Gene Detail
Summary
  • Symbol
    Trp53inp1
  • Name
    transformation related protein 53 inducible nuclear protein 1
  • Synonyms
    2700057G22Rik, SIP, SIP18, SIP27, Stinp, Teap
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926609
    NCBI Gene: 60599
  • Gene Overview
    MyGene.info: TP53INP1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:11156431-11174379 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17949 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 5.03 cM, cytoband A1-A2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TP53INP1, tumor protein p53 inducible nuclear protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TP53INP1, tumor protein p53 inducible nuclear protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p53DINP1, SIP, Teap, TP53DINP1, TP53INP1A, TP53INP1B
  • Links
    NCBI Gene ID: 94241
    neXtProt AC: NX_Q96A56
    UniProt: Q96A56

  • Chr Location
    8q22.1; chr8:94925972-94949387 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Trp53inp1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased plasma and colon oxidative stress, and show increased susceptibility to experimental induction of colorectal tumorigenesis and acute colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000004505 VEGA Gene Model | MGI Sequence Detail 17949 C57BL/6J ±  kb
    transcript OTTMUST00000010206 VEGA | MGI Sequence Detail 5404 Not Applicable  
    polypeptide OTTMUSP00000004858 VEGA | MGI Sequence Detail 239 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      87 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000030462 tumor protein p53-inducible nuclear protein 1
    • InterPro Domains
      IPR029556 Tumor protein p53-inducible nuclear protein 1
      IPR029431 Tumour protein p53-inducible nuclear protein
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 1
      cDNA 10
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919826
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:62615 Carrier A, et al., Differential gene expression in CD3epsilon- and RAG1-deficient thymuses: definition of a set of genes potentially involved in thymocyte maturation. Immunogenetics. 1999 Dec;50(5-6):255-70
    • Latest
      J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory