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Trp53inp1
Gene Detail
Symbol

Name
ID
Trp53inp1
transformation related protein 53 inducible nuclear protein 1
MGI:1926609
Synonyms
2700057G22Rik, SIP, SIP18, SIP27, Stinp, Teap
Feature Type
protein coding gene
Genetic Map
Chromosome 4
5.03 cM, cytoband A1-A2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:11156431-11174379 bp, + strand
From VEGA annotation of GRCm38

  17949 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11065  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TP53INP1
Gene Tree: Trp53inp1

Human
homologs
TP53INP1, tumor protein p53 inducible nuclear protein 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 94241
neXtProt AC: NX_Q96A56

Human Synonyms: p53DINP1, SIP, Teap, TP53DINP1, TP53INP1A, TP53INP1B

Human Chr (Location): 8q22; chr8:94925972-94949387 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(20) Targeted(3)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit increased plasma and colon oxidative stress, and show increased susceptibility to experimental induction of colorectal tumorigenesis and acute colitis.
 
Interactions
Trp53inp1 interacts with 423 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process apoptotic process, autophagic cell death, ...
Component autophagosome, cytoplasm, ...
Function antioxidant activity
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (133)    Tissues (133)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 133
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN tp53inp1    NEW 
Molecular
reagents
All nucleic(12) Genomic(1) cDNA(10) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000004505 (Evidence)
Ensembl Gene Model ENSMUSG00000028211 (Evidence)
Entrez Gene 60599 (Evidence)
DFCI TC1686880, TC1660258, TC1630140, TC1611108, TC1625872
DoTS DT.101709633, DT.101390910, DT.492071
NIA Mouse Gene Index U004064
Consensus CDS Project CCDS17964.1
International Mouse Phenotyping Consortium Status Trp53inp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004505 VEGA Gene Model | MGI Sequence Detail 17949 C57BL/6J ±  kb
transcript OTTMUST00000010206 VEGA | MGI Sequence Detail 5404 Not Applicable 
polypeptide OTTMUSP00000004858 VEGA | MGI Sequence Detail 239 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(89 from dbSNP Build 137)    SNPs within 2kb including multiple locations(91)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000030462 tumor protein p53-inducible nuclear protein 1
References
(Earliest) J:62615 Carrier A, et al., Differential gene expression in CD3epsilon- and RAG1-deficient thymuses: definition of a set of genes potentially involved in thymocyte maturation. Immunogenetics. 1999 Dec;50(5-6):255-70
(Latest) J:202459 Garg N, et al., microRNA-17-92 cluster is a direct Nanog target and controls neural stem cell through Trp53inp1. EMBO J. 2013 Oct 30;32(21):2819-32
All references(48)
Other
accession IDs
MGI:1919826

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory