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P2ry4 Gene Detail
Summary
  • Symbol
    P2ry4
  • Name
    pyrimidinergic receptor P2Y, G-protein coupled, 4
  • Synonyms
    P2Y4, P2Y4R
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926594
    NCBI Gene: 57385
  • Gene Overview
    MyGene.info: P2RY4
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:100590154-100594869 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 43.72 cM, cytoband C2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926594
protein coding gene ChrX:100588358-100594927 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035944
protein coding gene ChrX:97049647-97054362 (-)
A/J MGP_AJ_G0035929
protein coding gene ChrX:97093081-97098152 (-)
AKR/J MGP_AKRJ_G0035845
protein coding gene ChrX:99875931-99880638 (-)
BALB/cJ MGP_BALBcJ_G0035912
protein coding gene ChrX:95837253-95841960 (-)
C3H/HeJ MGP_C3HHeJ_G0035621
protein coding gene ChrX:97481666-97486373 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036441
protein coding gene ChrX:99961419-99966134 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033271
protein coding gene ChrX:94868290-94873176 (-)
CAST/EiJ MGP_CASTEiJ_G0034908
protein coding gene ChrX:81784374-81789063 (-)
CBA/J MGP_CBAJ_G0035596
protein coding gene ChrX:103056716-103061423 (-)
DBA/2J MGP_DBA2J_G0035750
protein coding gene ChrX:96297820-96302535 (-)
FVB/NJ MGP_FVBNJ_G0035688
protein coding gene ChrX:95698497-95703204 (-)
LP/J MGP_LPJ_G0035840
protein coding gene ChrX:98031582-98036297 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035723
protein coding gene ChrX:107585911-107590742 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036468
protein coding gene ChrX:96764927-96769634 (-)
PWK/PhJ MGP_PWKPhJ_G0034607
protein coding gene ChrX:79404343-79409060 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034435
protein coding gene ChrX:82668660-82673374 (-)
WSB/EiJ MGP_WSBEiJ_G0035047
protein coding gene ChrX:95482935-95487642 (-)



Homology
more
  • Human Ortholog
    P2RY4, pyrimidinergic receptor P2Y4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    P2RY4, pyrimidinergic receptor P2Y4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NRU, P2P, P2Y4, UNR
  • Links
    NCBI Gene ID: 5030
    neXtProt AC: NX_P51582
    UniProt: P51582

  • Chr Location
    Xq13.1; chrX:70258166-70259804 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous and hemizygous null mice display abnormal digestive secretion and homozygous null females display partially penetrant lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044359 Ensembl Gene Model | MGI Sequence Detail 4716 C57BL/6J ±  kb
transcript ENSMUST00000053373 Ensembl | MGI Sequence Detail 4434 Not Applicable  
polypeptide ENSMUSP00000055869 Ensembl | MGI Sequence Detail 361 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:85117 Lazarowski ER, et al., Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder. J Pharmacol Exp Ther. 2001 Apr;297(1):43-9
  • Latest
    J:205417 Li HQ, et al., P2Y4 receptor-mediated pinocytosis contributes to amyloid beta-induced self-uptake by microglia. Mol Cell Biol. 2013 Nov;33(21):4282-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory