Fancg
Gene Detail

Symbol Name ID

Fancg Fanconi anemia, complementation group G MGI:1926471

Synonyms

Xrcc9

Feature Type

protein coding gene

Genetic Map

Chromosome 4

22.97 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:43002343-43010506 bp, - strand From VEGA annotation of GRCm38   8164 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3402  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Fanconi anemia group G protein
Gene Tree: Fancg

Human homologs

Human Homolog		FANCG, Fanconi anemia, complementation group G
NCBI Gene ID		2189
neXtProt AC		NX_O15287
Human Synonyms		FAG, XRCC9
Human Chr (Location)		9p13; chr9:35073835-35080013 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FANCG

Alleles and phenotypes

All alleles(10) : Targeted(6) Gene trapped(4)
 

Females and males homozygous for targeted null mutations exhibit hypogonadism and reduced fertility. Cytogeneic analysis showed somatic chromosome aberrations occur at a higher spontaneous rate and are easier to induce than in normal cells. Cells are also more sensitive to mitomycin C.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	DNA repair, mitochondrion organization, ...
Component	Fanconi anaemia nuclear complex, mitochondrion, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (11)    Tissues (10)    Images (1)
Theiler Stages: 19, 22, 24

Assay Type	Results
RT-PCR	11

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) cDNA(31) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000006687 (Evidence)
Ensembl Gene Model	ENSMUSG00000028453 (Evidence)
Entrez Gene	60534 (Evidence)
UniGene	23122
DFCI	TC1580871, TC1591450, TC1708529
DoTS	DT.101367445, DT.91303074, DT.94170024, DT.97341454
NIA Mouse Gene Index	U024981
Consensus CDS Project	CCDS18087.1
International Mouse Knockout Project Status	Fancg

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006687	VEGA Gene Model | MGI Sequence Detail	8164	C57BL/6J
transcript	OTTMUST00000015341	VEGA | MGI Sequence Detail	2771	Not Applicable
polypeptide	OTTMUSP00000007084	VEGA | MGI Sequence Detail	623	Not Applicable

All sequences(51) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(8 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011990	Tetratricopeptide-like helical
InterPro	IPR013026	Tetratricopeptide repeat-containing domain
InterPro	IPR001440	Tetratricopeptide TPR-1
Protein Ontology	PR:000007336	Fanconi anemia group G protein

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:178857 Barroca V, et al., Impaired functionality and homing of Fancg-deficient hematopoietic stem cells. Hum Mol Genet. 2012 Jan 1;21(1):121-35
All references(48)

Other accession IDs

MGI:2140478