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Fancg
Gene Detail
Symbol

Name
ID
Fancg
Fanconi anemia, complementation group G
MGI:1926471
Synonyms
Xrcc9
Feature Type
protein coding gene
Genetic Map
Chromosome 4
22.97 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:43002343-43010506 bp, - strand
From VEGA annotation of GRCm38

  8164 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3402  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Fanconi anemia group G protein
Gene Tree: Fancg

Human
homologs
Human Homolog FANCG, Fanconi anemia, complementation group G
NCBI Gene ID 2189
neXtProt AC  NX_O15287
Human Synonyms  FAG, XRCC9
Human Chr (Location)  9p13; chr9:35073838-35080016 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human FANCG
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Females and males homozygous for targeted null mutations exhibit hypogonadism and reduced fertility. Cytogeneic analysis showed somatic chromosome aberrations occur at a higher spontaneous rate and are easier to induce than in normal cells. Cells are also more sensitive to mitomycin C.
 
Interactions
Fancg interacts with 105 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component cytoplasm, Fanconi anaemia nuclear complex, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (11)    Tissues (10)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 11
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) cDNA(31) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006687 (Evidence)
Ensembl Gene ModelENSMUSG00000028453 (Evidence)
Entrez Gene60534 (Evidence)
UniGene23122
DFCITC1591450, TC1708529, TC1580871
DoTSDT.97341454, DT.94170024, DT.91303074, DT.101367445
NIA Mouse Gene IndexU024981
Consensus CDS ProjectCCDS18087.1
International Mouse Knockout Project StatusFancg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006687 VEGA Gene Model | MGI Sequence Detail 8164 C57BL/6J ±  kb
transcript OTTMUST00000015341 VEGA | MGI Sequence Detail 2771 Not Applicable 
polypeptide OTTMUSP00000007084 VEGA | MGI Sequence Detail 623 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(21) UniProt(7)
Polymorphisms
SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
Protein Ontology PR:000007336 Fanconi anemia group G protein
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:213121 Nguyen TV, et al., Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells. J Exp Med. 2014 Jun 2;211(6):1011-8
All references(50)
Other
accession IDs
MGI:2140478

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory