Cdon
Gene Detail

Symbol Name ID

Cdon cell adhesion molecule-related/down-regulated by oncogenes MGI:1926387

Synonyms

CAM-related/down-regulated by oncogenes, CDO

Feature Type

protein coding gene

Genetic Map

Chromosome 9

20.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:35421128-35506119 bp, + strand From VEGA annotation of GRCm38   84992 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22996  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cdon

Human homologs

Human Homolog		CDON, cell adhesion associated, oncogene regulated
NCBI Gene ID		50937
neXtProt AC		NX_Q4KMG0
Human Synonyms		CDO, CDON1, HPE11, ORCAM
Human Chr (Location)		11q24.2; chr11:125826713-125933187 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CDON

Alleles and phenotypes

All alleles(8) : Targeted(5) Gene trapped(3)
 

Homozygous null mice display facial defects characteristic of microform holoprosencephaly, are runted, and are prone to death prior to weaning.

 
Human Diseases Modeled Using Mouse Cdon (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (39 annotations)

Process	anterior/posterior pattern specification, cell adhesion, ...
Component	cell surface, integral to membrane, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (212)    Tissues (154)    Images (40)
Theiler Stages: 9, 11, 13, 15, 17, 19, 20, 21, 23, 24, 25, 28

Assay Type	Results
RNA in situ	187
In situ reporter (knock in)	10
Western blot	15

cDNA source data(83)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(83) cDNA(83)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000030743 (Evidence)
Ensembl Gene Model	ENSMUSG00000038119 (Evidence)
Entrez Gene	57810 (Evidence)
UniGene	80509
DFCI	TC1584564, TC1624013, TC1665008, TC1708734
DoTS	DT.101739508, DT.94326051
NIA Mouse Gene Index	U010244
Consensus CDS Project	CCDS22964.1
International Mouse Knockout Project Status	Cdon

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030743	VEGA Gene Model | MGI Sequence Detail	84992	C57BL/6J
transcript	OTTMUST00000076106	VEGA | MGI Sequence Detail	5931	Not Applicable
polypeptide	OTTMUSP00000040005	VEGA | MGI Sequence Detail	1250	Not Applicable

All sequences(51) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(492 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
Protein Ontology	PR:000005282	cell adhesion molecule-related/down-regulated by oncogenes

References

(Earliest) J:65661 Kang JS, et al., CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. J Cell Biol. 1997 Jul 14;138(1):203-13
(Latest) J:193728 Hong M, et al., Cdon mutation and fetal ethanol exposure synergize to produce midline signaling defects and holoprosencephaly spectrum disorders in mice. PLoS Genet. 2012;8(10):e1002999
All references(56)