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Cdon
Gene Detail
 Symbol
Name
ID
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
MGI:1926387
Synonyms CAM-related/down-regulated by oncogenes, CDO
Feature Type protein coding gene
Genetic Map
Chromosome 9
20.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:35421128-35507652 bp, + strand
From VEGA annotation of GRCm38

  86525 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22996  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Cdon

Human
homologs
Human Homolog CDON, cell adhesion associated, oncogene regulated
NCBI Gene ID 50937
neXtProt AC  NX_Q4KMG0
Human Synonyms  CDO, CDON1, HPE11, ORCAM
Human Chr (Location)  11q24.2; chr11:125956818-126063292 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CDON
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display facial defects characteristic of microform holoprosencephaly, are runted, and are prone to death prior to weaning.
 
Human Diseases Modeled Using Mouse Cdon (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Cdon interacts with 374 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process anterior/posterior pattern specification, cell adhesion, ...
Component cell surface, integral component of membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (212)    Tissues (154)    Images (40)
Theiler Stages: 9, 11, 13, 15, 17, 19, 20, 21, 23, 24, 25, 28
Assay TypeResults
RNA in situ 187
In situ reporter (knock in) 10
Western blot 15
cDNA source data(83)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(83) cDNA(83)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000030743 (Evidence)
Ensembl Gene ModelENSMUSG00000038119 (Evidence)
Entrez Gene57810 (Evidence)
UniGene80509
DFCITC1584564, TC1624013, TC1665008, TC1708734
DoTSDT.101739508, DT.94326051
NIA Mouse Gene IndexU010244
Consensus CDS ProjectCCDS22964.1
International Mouse Knockout Project StatusCdon
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030743 VEGA Gene Model | MGI Sequence Detail 86525 C57BL/6J ±  kb
transcript OTTMUST00000076106 VEGA | MGI Sequence Detail 7464 Not Applicable 
polypeptide OTTMUSP00000040005 VEGA | MGI Sequence Detail 1250 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(19) UniProt(6)
Polymorphisms SNPs within 2kb(1051 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1053)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000005282 cell adhesion molecule-related/down-regulated by oncogenes
References (Earliest) J:65661 Kang JS, et al., CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. J Cell Biol. 1997 Jul 14;138(1):203-13
(Latest) J:209703 Hong M, et al., Rescue of holoprosencephaly in fetal alcohol-exposed Cdon mutant mice by reduced gene dosage of Ptch1. PLoS One. 2013;8(11):e79269
All references(61)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory