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Cdon Gene Detail
Summary
  • Symbol
    Cdon
  • Name
    cell adhesion molecule-related/down-regulated by oncogenes
  • Synonyms
    CAM-related/down-regulated by oncogenes, CDO
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926387
    NCBI Gene: 57810
  • Gene Overview
    MyGene.info: CDON
Location & Maps
more
  • Sequence Map
    Chr9:35421128-35507652 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      86525 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 20.24 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CDON, cell adhesion associated, oncogene regulated
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CDON, cell adhesion associated, oncogene regulated
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDO, CDON1, HPE11, ORCAM
  • Links
    NCBI Gene ID: 50937
    neXtProt AC: NX_Q4KMG0

  • Chr Location
    11q24.2; chr11:125956818-126063292 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Cdon mouse models; 1 with human CDON associations

Human Disease Mouse Models
       Holoprosencephaly 11; HPE11   OMIM: 614226 View 8 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 3 alleles in 5 genetic backgrounds
    41 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    3
  • Targeted
    6
  • Incidental Mutations
Homozygous null mice display facial defects characteristic of microform holoprosencephaly, are runted, and are prone to death prior to weaning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030743 VEGA Gene Model | MGI Sequence Detail 86525 C57BL/6J ±  kb
transcript OTTMUST00000076106 VEGA | MGI Sequence Detail 7464 Not Applicable  
polypeptide OTTMUSP00000040005 VEGA | MGI Sequence Detail 1250 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1042 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 83
    cDNA 83

    Microarray probesets 3
References
more
  • Summaries
    All 63
    Developmental Gene Expression 21
    Diseases 3
    Gene Ontology 15
    Phenotypes 29
  • Earliest
    J:65661 Kang JS, et al., CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. J Cell Biol. 1997 Jul 14;138(1):203-13
  • Latest
    J:229257 Gu Z, et al., Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory