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Cdon
Gene Detail
Symbol

Name
ID
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
MGI:1926387
Synonyms
CAM-related/down-regulated by oncogenes, CDO
Feature Type
protein coding gene
Genetic Map
Chromosome 9
20.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:35421124-35507652 bp, + strand
From VEGA annotation of GRCm38

  86529 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22996  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: CDON
Gene Tree: Cdon

Human
homologs
CDON, cell adhesion associated, oncogene regulated
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 50937
neXtProt AC: NX_Q4KMG0

Human Synonyms: CDO, CDON1, HPE11, ORCAM

Human Chr (Location): 11q24.2; chr11:125956818-126063292 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CDON

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display facial defects characteristic of microform holoprosencephaly, are runted, and are prone to death prior to weaning.
 
Human Diseases Modeled in Mice Using Cdon (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Cdon interacts with 373 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process anterior/posterior pattern specification, cell adhesion, ...
Component cell surface, integral component of membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (212)    Tissues (154)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 187
In situ reporter (knock in) 10
Western blot 15
cDNA source data(83)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase cdon ; ZFIN cdon    NEW 
Molecular
reagents
All nucleic(83) cDNA(83)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000030743 (Evidence)
Ensembl Gene Model ENSMUSG00000038119 (Evidence)
Entrez Gene 57810 (Evidence)
UniGene 80509
DFCI TC1708734, TC1624013, TC1665008, TC1584564
DoTS DT.101739508, DT.94326051
NIA Mouse Gene Index U010244
Consensus CDS Project CCDS22964.1
International Mouse Phenotyping Consortium Status Cdon
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030743 VEGA Gene Model | MGI Sequence Detail 86529 C57BL/6J ±  kb
transcript OTTMUST00000076106 VEGA | MGI Sequence Detail 7464 Not Applicable 
polypeptide OTTMUSP00000040005 VEGA | MGI Sequence Detail 1250 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(23) UniProt(6)
Polymorphisms
SNPs within 2kb(1051 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1053)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000005282 cell adhesion molecule-related/down-regulated by oncogenes
References
(Earliest) J:65661 Kang JS, et al., CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. J Cell Biol. 1997 Jul 14;138(1):203-13
(Latest) J:218163 Jin S, et al., Gas1 is a receptor for sonic hedgehog to repel enteric axons. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E73-80
All references(63)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory