Rassf5
Gene Detail

Symbol Name ID

Rassf5 Ras association (RalGDS/AF-6) domain family member 5 MGI:1926375

Synonyms

1300019G20Rik, Nore1A, Nore1B, Rapl

Feature Type

protein coding gene

Genetic Map

Chromosome 1

56.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:131176410-131245258 bp, - strand From VEGA annotation of GRCm38   68849 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10296  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle

Gene Tree: Rassf5

Human homologs

Human Homolog		RASSF5, Ras association (RalGDS/AF-6) domain family member 5
NCBI Gene ID		83593
neXtProt AC		NX_Q8WWW0
Human Synonyms		Maxp1, NORE1, NORE1A, NORE1B, RAPL, RASSF3
Human Chr (Location)		1q32.1; chr1:206680879-206762616 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygotes for a null allele have defects in lymphocyte homing to lymphoid tissues, B cell maturation and dendritic cell function, and display lymphocyte hyperproliferation leading to lupus glomerulonephritis and lymphomas. Homozygotes for another null allele are resistant to TNF-induced apoptosis.

 
Human Diseases Modeled Using Mouse Rassf5 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	apoptotic process, intracellular signal transduction, ...
Component	cytoplasm, cytoskeleton, ...
Function	metal ion binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (6)    Tissues (3)    Images (5)
Theiler Stages: 21, 23, 24

Assay Type	Results
RNA in situ	4
RT-PCR	2

cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(36) cDNA(34) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000021554 (Evidence)
Ensembl Gene Model	ENSMUSG00000026430 (Evidence)
Entrez Gene	54354 (Evidence)
UniGene	248291
DFCI	TC1578055, TC1702152, TC1747344
DoTS	DT.101311898, DT.101345755, DT.99844192
NIA Mouse Gene Index	U021749
PDB	1RFH, 2FNF, 3DDC
Consensus CDS Project	CCDS15268.1
International Mouse Knockout Project Status	Rassf5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021554	VEGA Gene Model | MGI Sequence Detail	68849	C57BL/6J
transcript	OTTMUST00000051125	VEGA | MGI Sequence Detail	3485	Not Applicable
polypeptide	OTTMUSP00000024015	VEGA | MGI Sequence Detail	413	Not Applicable

All sequences(40) RefSeq(2) UniProt(2)

Polymorphisms

PCR(1) : SNPs(505 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro	IPR000159	Ras-association
InterPro	IPR011524	SARAH
Protein Ontology	PR:000013766	ras association domain-containing protein 5

References

(Earliest) J:46202 Vavvas D, et al., Identification of Nore1 as a potential Ras effector. J Biol Chem. 1998 Mar 6;273(10):5439-42
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(48)

Other accession IDs

MGI:1921412, MGI:2138497