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Rassf5 Gene Detail
Summary
  • Symbol
    Rassf5
  • Name
    Ras association (RalGDS/AF-6) domain family member 5
  • Synonyms
    1300019G20Rik, Nore1A, Nore1B, Rapl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926375
    NCBI Gene: 54354
  • Gene Overview
    MyGene.info: RASSF5
Location & Maps
more
  • Sequence Map
    Chr1:131176410-131245258 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      68849 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 56.91 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    RASSF5, Ras association domain family member 5
  • Vertebrate Orthologs
    6
  • Human Ortholog
    RASSF5, Ras association domain family member 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Maxp1, NORE1, NORE1A, NORE1B, RAPL, RASSF3
  • Links
    NCBI Gene ID: 83593
    neXtProt AC: NX_Q8WWW0

  • Chr Location
    1q32.1; chr1:206507530-206589284 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Rassf5 mouse models

Human Disease Mouse Models
       Systemic Lupus Erythematosus; SLE   OMIM: 152700 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    3 involving Rassf5
  • Incidental Mutations
Homozygotes for a null allele have defects in lymphocyte homing to lymphoid tissues, B cell maturation and dendritic cell function, and display lymphocyte hyperproliferation leading to lupus glomerulonephritis and lymphomas. Homozygotes for another null allele are resistant to TNF-induced apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021554 VEGA Gene Model | MGI Sequence Detail 68849 C57BL/6J ±  kb
transcript OTTMUST00000051125 VEGA | MGI Sequence Detail 3485 Not Applicable  
polypeptide OTTMUSP00000024015 VEGA | MGI Sequence Detail 413 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    607 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 36
    cDNA 34
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1921412, MGI:2138497
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 9
    Phenotypes 15
  • Earliest
    J:46202 Vavvas D, et al., Identification of Nore1 as a potential Ras effector. J Biol Chem. 1998 Mar 6;273(10):5439-42
  • Latest
    J:227247 Brommage R, et al., High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Bone Res. 2014;2:14034

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory