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Rassf5
Gene Detail
Symbol

Name
ID
Rassf5
Ras association (RalGDS/AF-6) domain family member 5
MGI:1926375
Synonyms
1300019G20Rik, Nore1A, Nore1B, Rapl
Feature Type
protein coding gene
Genetic Map
Chromosome 1
56.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:131176410-131245258 bp, - strand
From VEGA annotation of GRCm38

  68849 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10296  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 zebrafish

Gene Tree: Rassf5

Human
homologs
Human Homolog RASSF5, Ras association (RalGDS/AF-6) domain family member 5
NCBI Gene ID 83593
neXtProt AC  NX_Q8WWW0
Human Synonyms  Maxp1, NORE1, NORE1A, NORE1B, RAPL, RASSF3
Human Chr (Location)  1q32.1; chr1:206507546-206589284 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele have defects in lymphocyte homing to lymphoid tissues, B cell maturation and dendritic cell function, and display lymphocyte hyperproliferation leading to lupus glomerulonephritis and lymphomas. Homozygotes for another null allele are resistant to TNF-induced apoptosis.
 
Human Diseases Modeled Using Mouse Rassf5 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Rassf5 interacts with 265 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process apoptotic process, intracellular signal transduction, ...
Component cytoplasm, cytoskeleton, ...
Function metal ion binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (6)    Tissues (3)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
RT-PCR 2
cDNA source data(33)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) cDNA(34) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021554 (Evidence)
Ensembl Gene ModelENSMUSG00000026430 (Evidence)
Entrez Gene54354 (Evidence)
UniGene248291
DFCITC1747344, TC1702152, TC1578055
DoTSDT.101311898, DT.101345755, DT.99844192
NIA Mouse Gene IndexU021749
PDB2FNF, 1RFH, 3DDC, 2YMY
Consensus CDS ProjectCCDS15268.1
International Mouse Knockout Project StatusRassf5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021554 VEGA Gene Model | MGI Sequence Detail 68849 C57BL/6J ±  kb
transcript OTTMUST00000051125 VEGA | MGI Sequence Detail 3485 Not Applicable 
polypeptide OTTMUSP00000024015 VEGA | MGI Sequence Detail 413 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(619 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR000159 Ras-association
InterPro IPR011524 SARAH domain
Protein Ontology PR:000013766 ras association domain-containing protein 5
References
(Earliest) J:46202 Vavvas D, et al., Identification of Nore1 as a potential Ras effector. J Biol Chem. 1998 Mar 6;273(10):5439-42
(Latest) J:209114 Gordon M, et al., The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury. PLoS One. 2013;8(10):e75483
All references(49)
Disease annotation references (1)
Other
accession IDs
MGI:1921412, MGI:2138497

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory