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Tmem8 Gene Detail
Summary
  • Symbol
    Tmem8
  • Name
    transmembrane protein 8
  • Synonyms
    M83, Rxylt1, Tmem8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926283
    NCBI Gene: 60455
  • Gene Overview
    MyGene.info: TMEM8A
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:26113316-26123254 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 13.06 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926283
protein coding gene Chr17:26112691-26123254 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023390
protein coding gene Chr17:25248663-25260334 (+)
A/J MGP_AJ_G0023349
protein coding gene Chr17:24503319-24513255 (+)
AKR/J MGP_AKRJ_G0023315
protein coding gene Chr17:24611042-24620764 (+)
BALB/cJ MGP_BALBcJ_G0023354
protein coding gene Chr17:24723927-24733836 (+)
C3H/HeJ MGP_C3HHeJ_G0023114
protein coding gene Chr17:25002373-25012233 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023796
protein coding gene Chr17:26314965-26329074 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021272
protein coding gene Chr17:21960223-21970058 (+)
CAST/EiJ MGP_CASTEiJ_G0022616
protein coding gene Chr17:24901646-24913475 (+)
CBA/J MGP_CBAJ_G0023089
protein coding gene Chr17:27244869-27259842 (+)
DBA/2J MGP_DBA2J_G0023219
protein coding gene Chr17:24097198-24107134 (+)
FVB/NJ MGP_FVBNJ_G0023189
protein coding gene Chr17:23856539-23868991 (+)
LP/J MGP_LPJ_G0023296
protein coding gene Chr17:25532969-25542734 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023208
protein coding gene Chr17:26817425-26830393 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023836
protein coding gene Chr17:24957475-24968342 (+)
PWK/PhJ MGP_PWKPhJ_G0022365
protein coding gene Chr17:22865687-22875403 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022183
protein coding gene Chr17:23024792-23034510 (+)
WSB/EiJ MGP_WSBEiJ_G0022679
protein coding gene Chr17:24983589-24993533 (+)



Homology
more
  • Human Ortholog
    TMEM8A, transmembrane protein 8A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TMEM8A, transmembrane protein 8A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPI-PLA2, M83, PGAP6, TMEM6, TMEM8
  • Links
    NCBI Gene ID: 58986
    neXtProt AC: NX_Q9HCN3
    UniProt: Q9HCN3

  • Chr Location
    16p13.3; chr16:370776-381950 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defects in rostral-caudal axis patterning, embryonic growth arrest, and embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024180 Ensembl Gene Model | MGI Sequence Detail 9939 C57BL/6J ±  kb
transcript ENSMUST00000025010 Ensembl | MGI Sequence Detail 3464 Not Applicable  
polypeptide ENSMUSP00000025010 Ensembl | MGI Sequence Detail 769 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 62
    cDNA 62

    Microarray probesets 6
Other
Accession IDs
less
MGI:2147065
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:64829 Motohashi T, et al., Molecular cloning and chromosomal mapping of a novel five-span transmembrane protein gene, M83. Biochem Biophys Res Commun. 2000 Sep 16;276(1):244-50
  • Latest
    J:258200 Lee GH, et al., A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO. J Cell Biol. 2016 Dec 5;215(5):705-718

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory