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Mrpl12 Gene Detail
Summary
  • Symbol
    Mrpl12
  • Name
    mitochondrial ribosomal protein L12
  • Synonyms
    0610034O11Rik, 1500031N16Rik, MRP-L12, Rpml12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926273
    NCBI Gene: 56282
  • Gene Overview
    MyGene.info: MRPL12
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120484669-120488754 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 84.18 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    51 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926273
protein coding gene Chr11:120484613-120489065 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019505
protein coding gene Chr11:124953794-124958246 (+)
A/J MGP_AJ_G0019473
protein coding gene Chr11:119392953-119397405 (+)
AKR/J MGP_AKRJ_G0019443
protein coding gene Chr11:122985759-122990211 (+)
BALB/cJ MGP_BALBcJ_G0019448
protein coding gene Chr11:119748572-119753024 (+)
C3H/HeJ MGP_C3HHeJ_G0019254
protein coding gene Chr11:123321398-123325850 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019896
protein coding gene Chr11:128731259-128735711 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017522
protein coding gene Chr11:116381102-116385367 (+)
CAST/EiJ MGP_CASTEiJ_G0018808
protein coding gene Chr11:124810715-124815204 (+)
CBA/J MGP_CBAJ_G0019225
protein coding gene Chr11:133771069-133775521 (+)
DBA/2J MGP_DBA2J_G0019337
protein coding gene Chr11:118761857-118766309 (+)
FVB/NJ MGP_FVBNJ_G0019329
protein coding gene Chr11:118472005-118476480 (+)
LP/J MGP_LPJ_G0019409
protein coding gene Chr11:125255220-125259672 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019362
protein coding gene Chr11:132613074-132617526 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019936
protein coding gene Chr11:123671532-123675984 (+)
PWK/PhJ MGP_PWKPhJ_G0018574
protein coding gene Chr11:120195456-120199923 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018366
protein coding gene Chr11:123433041-123437702 (+)
WSB/EiJ MGP_WSBEiJ_G0018860
protein coding gene Chr11:123662936-123667413 (+)



Homology
more
  • Human Ortholog
    MRPL12, mitochondrial ribosomal protein L12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MRPL12, mitochondrial ribosomal protein L12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    5c5-2, L12mt, MRP-L31/34, MRPL7, MRPL7/L12, RPML12
  • Links
    NCBI Gene ID: 6182
    neXtProt AC: NX_P52815
    UniProt: P52815

  • Chr Location
    17q25.3; chr17:81703370-81707526 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2212
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MRPL12
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 56282 NCBI Gene Model | MGI Sequence Detail 4086 C57BL/6J ±  kb
transcript NM_027204 RefSeq | MGI Sequence Detail 998 C57BL/6  
polypeptide Q9DB15 UniProt | EBI | MGI Sequence Detail 201 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000010574 39S ribosomal protein L12, mitochondrial
  • InterPro Domains
    IPR000206 Ribosomal protein L7/L12
    IPR013823 Ribosomal protein L7/L12, C-terminal
    IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like
    IPR008932 Ribosomal protein L7/L12, oligomerisation
    IPR036235 Ribosomal protein L7/L12, oligomerisation domain superfamily
Molecular
Reagents
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  • All nucleic 15
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
less
MGI:1915632, MGI:1917008
References
more
  • Summaries
    All 36
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:64919 Graack HR, et al., Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle. Biochemistry. 1999 Dec 14;38(50):16569-77
  • Latest
    J:228941 Nouws J, et al., Mitochondrial Ribosomal Protein L12 Is Required for POLRMT Stability and Exists as Two Forms Generated by Alternative Proteolysis during Import. J Biol Chem. 2016 Jan 8;291(2):989-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory