About   Help   FAQ
Mrpl12 Gene Detail
Summary
  • Symbol
    Mrpl12
  • Name
    mitochondrial ribosomal protein L12
  • Synonyms
    0610034O11Rik, 1500031N16Rik, MRP-L12, Rpml12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926273
    NCBI Gene: 56282
  • Gene Overview
    MyGene.info: MRPL12
Location & Maps
more
  • Sequence Map
    Chr11:120484613-120489065 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4453 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 84.18 cM, cytoband E2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MRPL12, mitochondrial ribosomal protein L12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MRPL12, mitochondrial ribosomal protein L12
    Orthology source: HGNC, HomoloGene
  • Synonyms
    5c5-2, L12mt, MRP-L31/34, MRPL7, MRPL7/L12, RPML12
  • Links
    NCBI Gene ID: 6182
    neXtProt AC: NX_P52815

  • Chr Location
    17q25; chr17:81703370-81707526 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2212
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MRPL12
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004268 VEGA Gene Model | MGI Sequence Detail 4453 C57BL/6J ±  kb
transcript OTTMUST00000009671 VEGA | MGI Sequence Detail 1316 Not Applicable  
polypeptide OTTMUSP00000004660 VEGA | MGI Sequence Detail 201 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    54 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000010574 39S ribosomal protein L12, mitochondrial
  • InterPro Domains
    IPR000206 Ribosomal protein L7/L12
    IPR013823 Ribosomal protein L7/L12, C-terminal
    IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like
    IPR008932 Ribosomal protein L7/L12, oligomerisation
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 3
Other
Accession IDs
less
MGI:1915632, MGI:1917008
References
more
  • Summaries
    All 32
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:64919 Graack HR, et al., Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle. Biochemistry. 1999 Dec 14;38(50):16569-77
  • Latest
    J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory