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Tspan6
Gene Detail
 Symbol
Name
ID
Tspan6
tetraspanin 6
MGI:1926264
Synonyms 6720473L21Rik, Tm4sf6
Feature Type protein coding gene
Genetic Map
Chromosome X
55.47 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:133891068-133898429 bp, - strand
From VEGA annotation of GRCm38

  7362 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20700  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tetraspanin
Gene Tree: Tspan6

Human
homologs
Human Homolog TSPAN6, tetraspanin 6
NCBI Gene ID 7105
neXtProt AC  NX_O43657
Human Synonyms  T245, TM4SF6, TSPAN-6
Human Chr (Location)  Xq22; chrX:100627108-100637104 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Interactions
Tspan6 interacts with 137 markers (Mir10a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process negative regulation of NIK/NF-kappaB signaling, negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway, ...
Component extracellular vesicular exosome, integral component of membrane, ...
Function signal transducer activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (40)    Tissues (9)    Images (19)
Theiler Stages: 15, 17, 22, 23
Assay TypeResults
RNA in situ 38
RT-PCR 2
cDNA source data(62)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(63) cDNA(62) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000018712 (Evidence)
Ensembl Gene ModelENSMUSG00000067377 (Evidence)
Entrez Gene56496 (Evidence)
UniGene46701
DFCITC1575800, TC1656472, TC1758484
DoTSDT.101235065, DT.101372409, DT.94134192, DT.94185110
NIA Mouse Gene IndexU039692
Consensus CDS ProjectCCDS30387.1
International Mouse Knockout Project StatusTspan6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018712 VEGA Gene Model | MGI Sequence Detail 7362 C57BL/6J ±  kb
transcript OTTMUST00000045005 VEGA | MGI Sequence Detail 1765 Not Applicable 
polypeptide OTTMUSP00000020220 VEGA | MGI Sequence Detail 245 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000301 Tetraspanin
InterPro IPR018503 Tetraspanin, conserved site
InterPro IPR008952 Tetraspanin, EC2 domain
InterPro IPR018499 Tetraspanin/Peripherin
Protein Ontology PR:000016752 tetraspanin-6
References (Earliest) J:64920 Todd SC, et al., Sequences and expression of six new members of the tetraspanin/TM4SF family. Biochim Biophys Acta. 1998 Jul 30;1399(1):101-4
(Latest) J:201159 Zhou P, et al., Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15395-400
All references(37)
Other
accession IDs
MGI:1924400, MGI:2147866

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory